Bone health in spacefaring rodents and primates: systematic review and meta-analysis
Abstract Animals in space exploration studies serve both as a model for human physiology and as a means to understand the physiological effects of microgravity. To quantify the microgravity-induced changes to bone health in animals, we systematically searched Medline, Embase, Web of Science, BIOSIS,...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-06-01
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| Series: | npj Microgravity |
| Online Access: | https://doi.org/10.1038/s41526-021-00147-7 |
| _version_ | 1797643055208071168 |
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| author | Jingyan Fu Matthew Goldsmith Sequoia D. Crooks Sean F. Condon Martin Morris Svetlana V. Komarova |
| author_facet | Jingyan Fu Matthew Goldsmith Sequoia D. Crooks Sean F. Condon Martin Morris Svetlana V. Komarova |
| author_sort | Jingyan Fu |
| collection | DOAJ |
| description | Abstract Animals in space exploration studies serve both as a model for human physiology and as a means to understand the physiological effects of microgravity. To quantify the microgravity-induced changes to bone health in animals, we systematically searched Medline, Embase, Web of Science, BIOSIS, and NASA Technical reports. We selected 40 papers focusing on the bone health of 95 rats, 61 mice, and 9 rhesus monkeys from 22 space missions. The percentage difference from ground control in rodents was –24.1% [Confidence interval: −43.4, −4.9] for trabecular bone volume fraction and –5.9% [−8.0, −3.8] for the cortical area. In primates, trabecular bone volume fraction was lower by –25.2% [−35.6, −14.7] in spaceflight animals compared to GC. Bone formation indices in rodent trabecular and cortical bone were significantly lower in microgravity. In contrast, osteoclast numbers were not affected in rats and were variably affected in mice. Thus, microgravity induces bone deficits in rodents and primates likely through the suppression of bone formation. |
| first_indexed | 2024-03-11T14:09:07Z |
| format | Article |
| id | doaj.art-5384ced52f37482786ae0b63dde9cf18 |
| institution | Directory Open Access Journal |
| issn | 2373-8065 |
| language | English |
| last_indexed | 2024-03-11T14:09:07Z |
| publishDate | 2021-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Microgravity |
| spelling | doaj.art-5384ced52f37482786ae0b63dde9cf182023-11-02T00:47:41ZengNature Portfolionpj Microgravity2373-80652021-06-017111410.1038/s41526-021-00147-7Bone health in spacefaring rodents and primates: systematic review and meta-analysisJingyan Fu0Matthew Goldsmith1Sequoia D. Crooks2Sean F. Condon3Martin Morris4Svetlana V. Komarova5Shriners Hospitals for Children - CanadaShriners Hospitals for Children - CanadaShriners Hospitals for Children - CanadaShriners Hospitals for Children - CanadaSchulich Library of Physical Sciences, Life Sciences and Engineering, McGill UniversityShriners Hospitals for Children - CanadaAbstract Animals in space exploration studies serve both as a model for human physiology and as a means to understand the physiological effects of microgravity. To quantify the microgravity-induced changes to bone health in animals, we systematically searched Medline, Embase, Web of Science, BIOSIS, and NASA Technical reports. We selected 40 papers focusing on the bone health of 95 rats, 61 mice, and 9 rhesus monkeys from 22 space missions. The percentage difference from ground control in rodents was –24.1% [Confidence interval: −43.4, −4.9] for trabecular bone volume fraction and –5.9% [−8.0, −3.8] for the cortical area. In primates, trabecular bone volume fraction was lower by –25.2% [−35.6, −14.7] in spaceflight animals compared to GC. Bone formation indices in rodent trabecular and cortical bone were significantly lower in microgravity. In contrast, osteoclast numbers were not affected in rats and were variably affected in mice. Thus, microgravity induces bone deficits in rodents and primates likely through the suppression of bone formation.https://doi.org/10.1038/s41526-021-00147-7 |
| spellingShingle | Jingyan Fu Matthew Goldsmith Sequoia D. Crooks Sean F. Condon Martin Morris Svetlana V. Komarova Bone health in spacefaring rodents and primates: systematic review and meta-analysis npj Microgravity |
| title | Bone health in spacefaring rodents and primates: systematic review and meta-analysis |
| title_full | Bone health in spacefaring rodents and primates: systematic review and meta-analysis |
| title_fullStr | Bone health in spacefaring rodents and primates: systematic review and meta-analysis |
| title_full_unstemmed | Bone health in spacefaring rodents and primates: systematic review and meta-analysis |
| title_short | Bone health in spacefaring rodents and primates: systematic review and meta-analysis |
| title_sort | bone health in spacefaring rodents and primates systematic review and meta analysis |
| url | https://doi.org/10.1038/s41526-021-00147-7 |
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