Background Parenchymal Enhancement of the Contralateral Normal Breast: Association with Tumor Response in Breast Cancer Patients Receiving Neoadjuvant Chemotherapy
PURPOSE: This study investigated the association between background parenchymal enhancement (BPE) and pathologic response to neoadjuvant chemotherapy (NAC). METHODS: A total of 46 patients diagnosed with invasive breast cancer were analyzed. Each patient had three magnetic resonance imaging (MRI) st...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2015-06-01
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| Series: | Translational Oncology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1936523315000285 |
| _version_ | 1819175713177075712 |
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| author | Jeon Hor Chen Hon J. Yu Christine Hsu Rita S. Mehta Philip M. Carpenter Min Ying Su |
| author_facet | Jeon Hor Chen Hon J. Yu Christine Hsu Rita S. Mehta Philip M. Carpenter Min Ying Su |
| author_sort | Jeon Hor Chen |
| collection | DOAJ |
| description | PURPOSE: This study investigated the association between background parenchymal enhancement (BPE) and pathologic response to neoadjuvant chemotherapy (NAC). METHODS: A total of 46 patients diagnosed with invasive breast cancer were analyzed. Each patient had three magnetic resonance imaging (MRI) studies, one pre-treatment and two follow-up (F/U) MRI studies. BPE was measured as the averaged enhancement of the whole fibroglandular tissues. The pre-treatment BPE and the changes in the F/U MRI were compared between patients achieving pathologic complete response (pCR) versus those not. Subgroup analyses based on age, estrogen receptor (ER), and human epidermal growth factor receptor 2 (HER2) status of their cancers were also performed. RESULTS: The pre-treatment BPE was higher in the pCR group than that in the non-pCR group. Compared to baseline, BPE at F/U-1 was significantly decreased in the pCR group but not in the non-pCR group. In subgroup analysis based on age, these results were seen only in the younger group (<55 years old), not in the older group (≥55 years old). Older patients had a significantly lower pre-treatment BPE than younger patients. In analysis based on molecular biomarkers, a significantly decreased BPE at F/U-1 was only found in the ER-negative pCR group but not in the non-pCR, nor in the ER-positive groups. CONCLUSIONS: A higher pre-treatment BPE showing a significant decrease early after starting NAC was related to pCR in pre/peri-menopausal patients. |
| first_indexed | 2024-12-22T20:59:14Z |
| format | Article |
| id | doaj.art-53855678360a4abc954f338fd6733be0 |
| institution | Directory Open Access Journal |
| issn | 1936-5233 1944-7124 |
| language | English |
| last_indexed | 2024-12-22T20:59:14Z |
| publishDate | 2015-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Translational Oncology |
| spelling | doaj.art-53855678360a4abc954f338fd6733be02022-12-21T18:12:52ZengElsevierTranslational Oncology1936-52331944-71242015-06-018320420910.1016/j.tranon.2015.04.001Background Parenchymal Enhancement of the Contralateral Normal Breast: Association with Tumor Response in Breast Cancer Patients Receiving Neoadjuvant ChemotherapyJeon Hor Chen0Hon J. Yu1Christine Hsu2Rita S. Mehta3Philip M. Carpenter4Min Ying Su5Center for Functional Onco-Imaging, Department of Radiological Sciences, University of California, Irvine, Irvine, CA, USACenter for Functional Onco-Imaging, Department of Radiological Sciences, University of California, Irvine, Irvine, CA, USACenter for Functional Onco-Imaging, Department of Radiological Sciences, University of California, Irvine, Irvine, CA, USADepartment of Medicine, University of California, Irvine, Irvine, CA, USADepartment of Pathology, University of California, Irvine, Irvine, CA, USACenter for Functional Onco-Imaging, Department of Radiological Sciences, University of California, Irvine, Irvine, CA, USAPURPOSE: This study investigated the association between background parenchymal enhancement (BPE) and pathologic response to neoadjuvant chemotherapy (NAC). METHODS: A total of 46 patients diagnosed with invasive breast cancer were analyzed. Each patient had three magnetic resonance imaging (MRI) studies, one pre-treatment and two follow-up (F/U) MRI studies. BPE was measured as the averaged enhancement of the whole fibroglandular tissues. The pre-treatment BPE and the changes in the F/U MRI were compared between patients achieving pathologic complete response (pCR) versus those not. Subgroup analyses based on age, estrogen receptor (ER), and human epidermal growth factor receptor 2 (HER2) status of their cancers were also performed. RESULTS: The pre-treatment BPE was higher in the pCR group than that in the non-pCR group. Compared to baseline, BPE at F/U-1 was significantly decreased in the pCR group but not in the non-pCR group. In subgroup analysis based on age, these results were seen only in the younger group (<55 years old), not in the older group (≥55 years old). Older patients had a significantly lower pre-treatment BPE than younger patients. In analysis based on molecular biomarkers, a significantly decreased BPE at F/U-1 was only found in the ER-negative pCR group but not in the non-pCR, nor in the ER-positive groups. CONCLUSIONS: A higher pre-treatment BPE showing a significant decrease early after starting NAC was related to pCR in pre/peri-menopausal patients.http://www.sciencedirect.com/science/article/pii/S1936523315000285 |
| spellingShingle | Jeon Hor Chen Hon J. Yu Christine Hsu Rita S. Mehta Philip M. Carpenter Min Ying Su Background Parenchymal Enhancement of the Contralateral Normal Breast: Association with Tumor Response in Breast Cancer Patients Receiving Neoadjuvant Chemotherapy Translational Oncology |
| title | Background Parenchymal Enhancement of the Contralateral Normal Breast: Association with Tumor Response in Breast Cancer Patients Receiving Neoadjuvant Chemotherapy |
| title_full | Background Parenchymal Enhancement of the Contralateral Normal Breast: Association with Tumor Response in Breast Cancer Patients Receiving Neoadjuvant Chemotherapy |
| title_fullStr | Background Parenchymal Enhancement of the Contralateral Normal Breast: Association with Tumor Response in Breast Cancer Patients Receiving Neoadjuvant Chemotherapy |
| title_full_unstemmed | Background Parenchymal Enhancement of the Contralateral Normal Breast: Association with Tumor Response in Breast Cancer Patients Receiving Neoadjuvant Chemotherapy |
| title_short | Background Parenchymal Enhancement of the Contralateral Normal Breast: Association with Tumor Response in Breast Cancer Patients Receiving Neoadjuvant Chemotherapy |
| title_sort | background parenchymal enhancement of the contralateral normal breast association with tumor response in breast cancer patients receiving neoadjuvant chemotherapy |
| url | http://www.sciencedirect.com/science/article/pii/S1936523315000285 |
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