FcRL4 Expression Identifies a Pro-inflammatory B Cell Subset in Viremic HIV-Infected Subjects

FcRL4 Expression Identifies a Pro-inflammatory B Cell Subset in Viremic HIV-Infected Subjects

In autoimmune diseases, toll-like receptor (TLR)-stimulated pro-inflammatory IL-6-secreting B cells exert pathogenic roles. Similarly, B cell Fc receptor-like 4 (FcRL4) expression amplifies TLR stimulation, and in rheumatoid arthritis patients, FcRL4 expression identifies a pro-inflammatory B cell s...

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Bibliographic Details
Main Authors: Basile Siewe, Allison J. Nipper, Haewon Sohn, Jack T. Stapleton, Alan Landay
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Immunology
Subjects:
Fc receptor-like 4
pro-inflammatory cytokine
HIV
B cells
IL-6
viremic
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01339/full

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