Th1 skewed immune response of whole virion inactivated SARS CoV 2 vaccine and its safety evaluation

Th1 skewed immune response of whole virion inactivated SARS CoV 2 vaccine and its safety evaluation

Summary: We report the development and evaluation of safety and immunogenicity of a whole virion inactivated (WVI) SARS-CoV-2 vaccine (BBV152), adjuvanted with aluminum hydroxide gel (Algel), or TLR7/8 agonist chemisorbed Algel. We used a well-characterized SARS-CoV-2 strain and an established Vero...

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Bibliographic Details
Main Authors: Brunda Ganneru, Harsh Jogdand, Vijaya Kumar Daram, Dipankar Das, Narasimha Reddy Molugu, Sai D. Prasad, Srinivas V. Kannappa, Krishna M. Ella, Rajaram Ravikrishnan, Amit Awasthi, Jomy Jose, Panduranga Rao, Deepak Kumar, Raches Ella, Priya Abraham, Pragya D. Yadav, Gajanan N. Sapkal, Anita Shete-Aich, Gururaj Desphande, Sreelekshmy Mohandas, Atanu Basu, Nivedita Gupta, Krishna Mohan Vadrevu
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:iScience
Subjects:
Immune Response
Immunology
Virology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221002662

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