Clinical Differences and Non-Alcoholic Fatty Liver Disease-Related Factors of Lean and Non-Lean Patients with Metabolic Syndrome
This study investigated differences in the clinical data and prevalence of lean and non-lean patients with non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome (MetS). Data on patients with MetS who had results of ultrasonography or transient elastography were collected from a Thai unive...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/9/2445 |
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| author | Punyisa Boonchai Chayanis Kositamongkol Suchanart Jitrukthai Sukumal Phothirat Euarat Mepramoon Pongpol Nimitpunya Weerachai Srivanichakorn Thanet Chaisathaphol Chaiwat Washirasaksiri Chonticha Auesomwang Tullaya Sitasuwan Rungsima Tinmanee Naruemit Sayabovorn Phunchai Charatcharoenwitthaya Pochamana Phisalprapa |
| author_facet | Punyisa Boonchai Chayanis Kositamongkol Suchanart Jitrukthai Sukumal Phothirat Euarat Mepramoon Pongpol Nimitpunya Weerachai Srivanichakorn Thanet Chaisathaphol Chaiwat Washirasaksiri Chonticha Auesomwang Tullaya Sitasuwan Rungsima Tinmanee Naruemit Sayabovorn Phunchai Charatcharoenwitthaya Pochamana Phisalprapa |
| author_sort | Punyisa Boonchai |
| collection | DOAJ |
| description | This study investigated differences in the clinical data and prevalence of lean and non-lean patients with non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome (MetS). Data on patients with MetS who had results of ultrasonography or transient elastography were collected from a Thai university hospital database. Patients with exclusion criteria for NAFLD diagnosis were excluded. Patients’ clinical characteristic and the performances of three non-invasive scoring systems (fatty liver index [FLI], fibrosis-4 [FIB-4] index, and NAFLD fibrosis score [NFS]) were evaluated. The 743 subjects were classified into two groups: lean MetS (131 patients) and non-lean MetS (612 patients). The NAFLD prevalence in the non-lean group (62.6%) was higher than that in the lean group (31.3%). The age-adjusted odds ratio was 3.43. Advanced fibrosis was detected in 7.6% of lean patients and 10.8% of non-lean patients. FLI was not sensitive enough to detect NAFLD in the lean group at a high cutoff, but it performed acceptably at a low cutoff. FIB-4 performed better than NFS in determining advanced fibrosis. NAFLD was more common in non-lean than lean patients. Lean patients with MetS had a relatively higher risk of NAFLD than the general population. FLI and FIB-4 index performed acceptably in both groups. |
| first_indexed | 2024-03-10T04:01:23Z |
| format | Article |
| id | doaj.art-5389eecd8b084bfbb4f57da520f0e4eb |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T04:01:23Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-5389eecd8b084bfbb4f57da520f0e4eb2023-11-23T08:32:27ZengMDPI AGJournal of Clinical Medicine2077-03832022-04-01119244510.3390/jcm11092445Clinical Differences and Non-Alcoholic Fatty Liver Disease-Related Factors of Lean and Non-Lean Patients with Metabolic SyndromePunyisa Boonchai0Chayanis Kositamongkol1Suchanart Jitrukthai2Sukumal Phothirat3Euarat Mepramoon4Pongpol Nimitpunya5Weerachai Srivanichakorn6Thanet Chaisathaphol7Chaiwat Washirasaksiri8Chonticha Auesomwang9Tullaya Sitasuwan10Rungsima Tinmanee11Naruemit Sayabovorn12Phunchai Charatcharoenwitthaya13Pochamana Phisalprapa14Division of Ambulatory Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, ThailandDivision of Ambulatory Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, ThailandDivision of Ambulatory Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, ThailandDivision of Ambulatory Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, ThailandDivision of Ambulatory Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, ThailandDivision of Ambulatory Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, ThailandDivision of Ambulatory Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, ThailandDivision of Ambulatory Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, ThailandDivision of Ambulatory Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, ThailandDivision of Ambulatory Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, ThailandDivision of Ambulatory Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, ThailandDivision of Ambulatory Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, ThailandDivision of Ambulatory Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, ThailandDivision of Gastroenterology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, ThailandDivision of Ambulatory Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, ThailandThis study investigated differences in the clinical data and prevalence of lean and non-lean patients with non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome (MetS). Data on patients with MetS who had results of ultrasonography or transient elastography were collected from a Thai university hospital database. Patients with exclusion criteria for NAFLD diagnosis were excluded. Patients’ clinical characteristic and the performances of three non-invasive scoring systems (fatty liver index [FLI], fibrosis-4 [FIB-4] index, and NAFLD fibrosis score [NFS]) were evaluated. The 743 subjects were classified into two groups: lean MetS (131 patients) and non-lean MetS (612 patients). The NAFLD prevalence in the non-lean group (62.6%) was higher than that in the lean group (31.3%). The age-adjusted odds ratio was 3.43. Advanced fibrosis was detected in 7.6% of lean patients and 10.8% of non-lean patients. FLI was not sensitive enough to detect NAFLD in the lean group at a high cutoff, but it performed acceptably at a low cutoff. FIB-4 performed better than NFS in determining advanced fibrosis. NAFLD was more common in non-lean than lean patients. Lean patients with MetS had a relatively higher risk of NAFLD than the general population. FLI and FIB-4 index performed acceptably in both groups.https://www.mdpi.com/2077-0383/11/9/2445Asianliver fibrosismetabolic syndromenon-alcoholic fatty liver diseasenon-invasive scoring systemtransient elastography |
| spellingShingle | Punyisa Boonchai Chayanis Kositamongkol Suchanart Jitrukthai Sukumal Phothirat Euarat Mepramoon Pongpol Nimitpunya Weerachai Srivanichakorn Thanet Chaisathaphol Chaiwat Washirasaksiri Chonticha Auesomwang Tullaya Sitasuwan Rungsima Tinmanee Naruemit Sayabovorn Phunchai Charatcharoenwitthaya Pochamana Phisalprapa Clinical Differences and Non-Alcoholic Fatty Liver Disease-Related Factors of Lean and Non-Lean Patients with Metabolic Syndrome Journal of Clinical Medicine Asian liver fibrosis metabolic syndrome non-alcoholic fatty liver disease non-invasive scoring system transient elastography |
| title | Clinical Differences and Non-Alcoholic Fatty Liver Disease-Related Factors of Lean and Non-Lean Patients with Metabolic Syndrome |
| title_full | Clinical Differences and Non-Alcoholic Fatty Liver Disease-Related Factors of Lean and Non-Lean Patients with Metabolic Syndrome |
| title_fullStr | Clinical Differences and Non-Alcoholic Fatty Liver Disease-Related Factors of Lean and Non-Lean Patients with Metabolic Syndrome |
| title_full_unstemmed | Clinical Differences and Non-Alcoholic Fatty Liver Disease-Related Factors of Lean and Non-Lean Patients with Metabolic Syndrome |
| title_short | Clinical Differences and Non-Alcoholic Fatty Liver Disease-Related Factors of Lean and Non-Lean Patients with Metabolic Syndrome |
| title_sort | clinical differences and non alcoholic fatty liver disease related factors of lean and non lean patients with metabolic syndrome |
| topic | Asian liver fibrosis metabolic syndrome non-alcoholic fatty liver disease non-invasive scoring system transient elastography |
| url | https://www.mdpi.com/2077-0383/11/9/2445 |
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