Morbidity and Mortality of Heterotopic Partial Heart Transplantation in Rodent Models
Unrepairable congenital heart valve disease is an unsolved problem in pediatric cardiac surgery because there are no growing heart valve implants. Partial heart transplantation is a new type of transplant that aims to solve this problem. In order to study the unique transplant biology of partial hea...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-05-01
|
| Series: | Journal of Cardiovascular Development and Disease |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2308-3425/10/6/234 |
| _version_ | 1797594138470776832 |
|---|---|
| author | Savannah Skidmore Morgan A. Hill Katherine Bishara Haley Konsek Jennie H. Kwon Kelvin G. M. Brockbank Taufiek Konrad Rajab |
| author_facet | Savannah Skidmore Morgan A. Hill Katherine Bishara Haley Konsek Jennie H. Kwon Kelvin G. M. Brockbank Taufiek Konrad Rajab |
| author_sort | Savannah Skidmore |
| collection | DOAJ |
| description | Unrepairable congenital heart valve disease is an unsolved problem in pediatric cardiac surgery because there are no growing heart valve implants. Partial heart transplantation is a new type of transplant that aims to solve this problem. In order to study the unique transplant biology of partial heart transplantation, animal models are necessary. This study aimed to assess the morbidity and mortality of heterotopic partial heart transplantation in rodent models. This study assessed two models. The first model involved transplanting heart valves from donor animals into the abdominal aortic position in the recipient animals. The second model involved transplanting heart valve leaflets into the renal subcapsular position of the recipient animals. A total of 33 animals underwent heterotopic partial heart transplantation in the abdominal aortic position. The results of this model found a 60.61% (<i>n</i> = 20/33) intraoperative mortality rate and a 39.39% (<i>n</i> = 13/33) perioperative mortality rate. Intraoperative mortality was due to vascular complications from the procedure, and perioperative mortality was due to graft thrombosis. A total of 33 animals underwent heterotopic partial heart transplantation in the renal subcapsular position. The results of this model found a 3.03% (<i>n</i> = 1/33) intraoperative mortality rate, and the remaining 96.97% survived (<i>n</i> = 32/33). We conclude that the renal subcapsular model has a lower mortality rate and is technically more accessible than the abdominal aortic model. While the heterotopic transplantation of valves into the abdominal aortic position had significant morbidity and mortality in the rodent model, the renal subcapsular model provided evidence for successful heterotopic transplantation. |
| first_indexed | 2024-03-11T02:19:18Z |
| format | Article |
| id | doaj.art-538a113c8cbf423780e5ef351d18693b |
| institution | Directory Open Access Journal |
| issn | 2308-3425 |
| language | English |
| last_indexed | 2024-03-11T02:19:18Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Cardiovascular Development and Disease |
| spelling | doaj.art-538a113c8cbf423780e5ef351d18693b2023-11-18T10:57:20ZengMDPI AGJournal of Cardiovascular Development and Disease2308-34252023-05-0110623410.3390/jcdd10060234Morbidity and Mortality of Heterotopic Partial Heart Transplantation in Rodent ModelsSavannah Skidmore0Morgan A. Hill1Katherine Bishara2Haley Konsek3Jennie H. Kwon4Kelvin G. M. Brockbank5Taufiek Konrad Rajab6College of Medicine, Medical University of South Carolina, Charleston, SC 29425, USACollege of Medicine, Medical University of South Carolina, Charleston, SC 29425, USACollege of Medicine, Medical University of South Carolina, Charleston, SC 29425, USACollege of Medicine, Medical University of South Carolina, Charleston, SC 29425, USADepartment of Cardiothoracic Surgery, Medical University of South Carolina, Charleston, SC 29425, USATissue Testing Technologies LLC, North Charleston, SC 29425, USADepartment of Pediatric Cardiothoracic Surgery, Medical University of South Carolina, Charleston, SC 29425, USAUnrepairable congenital heart valve disease is an unsolved problem in pediatric cardiac surgery because there are no growing heart valve implants. Partial heart transplantation is a new type of transplant that aims to solve this problem. In order to study the unique transplant biology of partial heart transplantation, animal models are necessary. This study aimed to assess the morbidity and mortality of heterotopic partial heart transplantation in rodent models. This study assessed two models. The first model involved transplanting heart valves from donor animals into the abdominal aortic position in the recipient animals. The second model involved transplanting heart valve leaflets into the renal subcapsular position of the recipient animals. A total of 33 animals underwent heterotopic partial heart transplantation in the abdominal aortic position. The results of this model found a 60.61% (<i>n</i> = 20/33) intraoperative mortality rate and a 39.39% (<i>n</i> = 13/33) perioperative mortality rate. Intraoperative mortality was due to vascular complications from the procedure, and perioperative mortality was due to graft thrombosis. A total of 33 animals underwent heterotopic partial heart transplantation in the renal subcapsular position. The results of this model found a 3.03% (<i>n</i> = 1/33) intraoperative mortality rate, and the remaining 96.97% survived (<i>n</i> = 32/33). We conclude that the renal subcapsular model has a lower mortality rate and is technically more accessible than the abdominal aortic model. While the heterotopic transplantation of valves into the abdominal aortic position had significant morbidity and mortality in the rodent model, the renal subcapsular model provided evidence for successful heterotopic transplantation.https://www.mdpi.com/2308-3425/10/6/234pediatric cardiac surgerypartial heart transplantationanimal modelcongenital cardiac surgeryvalve dysfunctionrodent |
| spellingShingle | Savannah Skidmore Morgan A. Hill Katherine Bishara Haley Konsek Jennie H. Kwon Kelvin G. M. Brockbank Taufiek Konrad Rajab Morbidity and Mortality of Heterotopic Partial Heart Transplantation in Rodent Models Journal of Cardiovascular Development and Disease pediatric cardiac surgery partial heart transplantation animal model congenital cardiac surgery valve dysfunction rodent |
| title | Morbidity and Mortality of Heterotopic Partial Heart Transplantation in Rodent Models |
| title_full | Morbidity and Mortality of Heterotopic Partial Heart Transplantation in Rodent Models |
| title_fullStr | Morbidity and Mortality of Heterotopic Partial Heart Transplantation in Rodent Models |
| title_full_unstemmed | Morbidity and Mortality of Heterotopic Partial Heart Transplantation in Rodent Models |
| title_short | Morbidity and Mortality of Heterotopic Partial Heart Transplantation in Rodent Models |
| title_sort | morbidity and mortality of heterotopic partial heart transplantation in rodent models |
| topic | pediatric cardiac surgery partial heart transplantation animal model congenital cardiac surgery valve dysfunction rodent |
| url | https://www.mdpi.com/2308-3425/10/6/234 |
| work_keys_str_mv | AT savannahskidmore morbidityandmortalityofheterotopicpartialhearttransplantationinrodentmodels AT morganahill morbidityandmortalityofheterotopicpartialhearttransplantationinrodentmodels AT katherinebishara morbidityandmortalityofheterotopicpartialhearttransplantationinrodentmodels AT haleykonsek morbidityandmortalityofheterotopicpartialhearttransplantationinrodentmodels AT jenniehkwon morbidityandmortalityofheterotopicpartialhearttransplantationinrodentmodels AT kelvingmbrockbank morbidityandmortalityofheterotopicpartialhearttransplantationinrodentmodels AT taufiekkonradrajab morbidityandmortalityofheterotopicpartialhearttransplantationinrodentmodels |