Cholesterol determines the cytosolic entry and seeded aggregation of tau

Cholesterol determines the cytosolic entry and seeded aggregation of tau

Summary: Assemblies of tau can transit between neurons, seeding aggregation in a prion-like manner. To accomplish this, tau must cross cell-limiting membranes, a process that is poorly understood. Here, we establish assays for the study of tau entry into the cytosol as a phenomenon distinct from upt...

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Bibliographic Details
Main Authors: Benjamin J. Tuck, Lauren V.C. Miller, Taxiarchis Katsinelos, Annabel E. Smith, Emma L. Wilson, Sophie Keeling, Shi Cheng, Marina J. Vaysburd, Claire Knox, Lucy Tredgett, Emmanouil Metzakopian, Leo C. James, William A. McEwan
Format: Article
Language:English
Published: Elsevier 2022-05-01
Series:Cell Reports
Subjects:
CP: Metabolism
CP: Neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S221112472200540X

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