Smart Biomimetic Nanozymes for Precise Molecular Imaging: Application and Challenges
New nanotechnologies for imaging molecules are widely being applied to visualize the expression of specific molecules (e.g., ions, biomarkers) for disease diagnosis. Among various nanoplatforms, nanozymes, which exhibit enzyme-like catalytic activities in vivo, have gained tremendously increasing at...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/16/2/249 |
| _version_ | 1797618809019826176 |
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| author | Qiao Luo Ni Shao Ai-Chen Zhang Chun-Fang Chen Duo Wang Liang-Ping Luo Ze-Yu Xiao |
| author_facet | Qiao Luo Ni Shao Ai-Chen Zhang Chun-Fang Chen Duo Wang Liang-Ping Luo Ze-Yu Xiao |
| author_sort | Qiao Luo |
| collection | DOAJ |
| description | New nanotechnologies for imaging molecules are widely being applied to visualize the expression of specific molecules (e.g., ions, biomarkers) for disease diagnosis. Among various nanoplatforms, nanozymes, which exhibit enzyme-like catalytic activities in vivo, have gained tremendously increasing attention in molecular imaging due to their unique properties such as diverse enzyme-mimicking activities, excellent biocompatibility, ease of surface tenability, and low cost. In addition, by integrating different nanoparticles with superparamagnetic, photoacoustic, fluorescence, and photothermal properties, the nanoenzymes are able to increase the imaging sensitivity and accuracy for better understanding the complexity and the biological process of disease. Moreover, these functions encourage the utilization of nanozymes as therapeutic agents to assist in treatment. In this review, we focus on the applications of nanozymes in molecular imaging and discuss the use of peroxidase (POD), oxidase (OXD), catalase (CAT), and superoxide dismutase (SOD) with different imaging modalities. Further, the applications of nanozymes for cancer treatment, bacterial infection, and inflammation image-guided therapy are discussed. Overall, this review aims to provide a complete reference for research in the interdisciplinary fields of nanotechnology and molecular imaging to promote the advancement and clinical translation of novel biomimetic nanozymes. |
| first_indexed | 2024-03-11T08:17:49Z |
| format | Article |
| id | doaj.art-538cd2babeb24d61bc1a3b2b27986428 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-11T08:17:49Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-538cd2babeb24d61bc1a3b2b279864282023-11-16T22:37:03ZengMDPI AGPharmaceuticals1424-82472023-02-0116224910.3390/ph16020249Smart Biomimetic Nanozymes for Precise Molecular Imaging: Application and ChallengesQiao Luo0Ni Shao1Ai-Chen Zhang2Chun-Fang Chen3Duo Wang4Liang-Ping Luo5Ze-Yu Xiao6The Guangzhou Key Laboratory of Molecular and Functional Imaging for Clinical Translation, The First Affiliated Hospital of Jinan University, Guangzhou 510632, ChinaThe Guangzhou Key Laboratory of Molecular and Functional Imaging for Clinical Translation, The First Affiliated Hospital of Jinan University, Guangzhou 510632, ChinaThe Guangzhou Key Laboratory of Molecular and Functional Imaging for Clinical Translation, The First Affiliated Hospital of Jinan University, Guangzhou 510632, ChinaThe Guangzhou Key Laboratory of Molecular and Functional Imaging for Clinical Translation, The First Affiliated Hospital of Jinan University, Guangzhou 510632, ChinaThe Guangzhou Key Laboratory of Molecular and Functional Imaging for Clinical Translation, The First Affiliated Hospital of Jinan University, Guangzhou 510632, ChinaThe Guangzhou Key Laboratory of Molecular and Functional Imaging for Clinical Translation, The First Affiliated Hospital of Jinan University, Guangzhou 510632, ChinaThe Guangzhou Key Laboratory of Molecular and Functional Imaging for Clinical Translation, The First Affiliated Hospital of Jinan University, Guangzhou 510632, ChinaNew nanotechnologies for imaging molecules are widely being applied to visualize the expression of specific molecules (e.g., ions, biomarkers) for disease diagnosis. Among various nanoplatforms, nanozymes, which exhibit enzyme-like catalytic activities in vivo, have gained tremendously increasing attention in molecular imaging due to their unique properties such as diverse enzyme-mimicking activities, excellent biocompatibility, ease of surface tenability, and low cost. In addition, by integrating different nanoparticles with superparamagnetic, photoacoustic, fluorescence, and photothermal properties, the nanoenzymes are able to increase the imaging sensitivity and accuracy for better understanding the complexity and the biological process of disease. Moreover, these functions encourage the utilization of nanozymes as therapeutic agents to assist in treatment. In this review, we focus on the applications of nanozymes in molecular imaging and discuss the use of peroxidase (POD), oxidase (OXD), catalase (CAT), and superoxide dismutase (SOD) with different imaging modalities. Further, the applications of nanozymes for cancer treatment, bacterial infection, and inflammation image-guided therapy are discussed. Overall, this review aims to provide a complete reference for research in the interdisciplinary fields of nanotechnology and molecular imaging to promote the advancement and clinical translation of novel biomimetic nanozymes.https://www.mdpi.com/1424-8247/16/2/249nanozymesmolecular imagingmagnetic resonance imagingphotoacoustic imagingpositron emission tomographymultimodal imaging |
| spellingShingle | Qiao Luo Ni Shao Ai-Chen Zhang Chun-Fang Chen Duo Wang Liang-Ping Luo Ze-Yu Xiao Smart Biomimetic Nanozymes for Precise Molecular Imaging: Application and Challenges Pharmaceuticals nanozymes molecular imaging magnetic resonance imaging photoacoustic imaging positron emission tomography multimodal imaging |
| title | Smart Biomimetic Nanozymes for Precise Molecular Imaging: Application and Challenges |
| title_full | Smart Biomimetic Nanozymes for Precise Molecular Imaging: Application and Challenges |
| title_fullStr | Smart Biomimetic Nanozymes for Precise Molecular Imaging: Application and Challenges |
| title_full_unstemmed | Smart Biomimetic Nanozymes for Precise Molecular Imaging: Application and Challenges |
| title_short | Smart Biomimetic Nanozymes for Precise Molecular Imaging: Application and Challenges |
| title_sort | smart biomimetic nanozymes for precise molecular imaging application and challenges |
| topic | nanozymes molecular imaging magnetic resonance imaging photoacoustic imaging positron emission tomography multimodal imaging |
| url | https://www.mdpi.com/1424-8247/16/2/249 |
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