Molecular Pathogenesis of Hodgkin Lymphoma: Past, Present, Future
Our understanding of the tumorigenesis of classical Hodgkin lymphoma (cHL) and the formation of Reed–Sternberg cells (RS-cells) has evolved drastically in the last decades. More recently, a better characterization of the signaling pathways and the cellular interactions at play have paved the way for...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-09-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/18/6623 |
| _version_ | 1797554058313072640 |
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| author | Marc Bienz Salima Ramdani Hans Knecht |
| author_facet | Marc Bienz Salima Ramdani Hans Knecht |
| author_sort | Marc Bienz |
| collection | DOAJ |
| description | Our understanding of the tumorigenesis of classical Hodgkin lymphoma (cHL) and the formation of Reed–Sternberg cells (RS-cells) has evolved drastically in the last decades. More recently, a better characterization of the signaling pathways and the cellular interactions at play have paved the way for new targeted therapy in the hopes of improving outcomes. However, important gaps in knowledge remain that may hold the key for significant changes of paradigm in this lymphoma. Here, we discuss the past, present, and future of cHL, and review in detail the more recent discoveries pertaining to genetic instability, anti-apoptotic signaling pathways, the tumoral microenvironment, and host-immune system evasion in cHL. |
| first_indexed | 2024-03-10T16:25:25Z |
| format | Article |
| id | doaj.art-538dc33d65e4499084a5d8e4651a7e89 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T16:25:25Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-538dc33d65e4499084a5d8e4651a7e892023-11-20T13:14:15ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-09-012118662310.3390/ijms21186623Molecular Pathogenesis of Hodgkin Lymphoma: Past, Present, FutureMarc Bienz0Salima Ramdani1Hans Knecht2Division of Hematology, Department of Medicine, Jewish General Hospital, McGill University, Montreal, QC H3T 1E2, CanadaDepartment of Medicine, McGill University, Montreal, QC H3T 1E2, CanadaDivision of Hematology, Department of Medicine, Jewish General Hospital, McGill University, Montreal, QC H3T 1E2, CanadaOur understanding of the tumorigenesis of classical Hodgkin lymphoma (cHL) and the formation of Reed–Sternberg cells (RS-cells) has evolved drastically in the last decades. More recently, a better characterization of the signaling pathways and the cellular interactions at play have paved the way for new targeted therapy in the hopes of improving outcomes. However, important gaps in knowledge remain that may hold the key for significant changes of paradigm in this lymphoma. Here, we discuss the past, present, and future of cHL, and review in detail the more recent discoveries pertaining to genetic instability, anti-apoptotic signaling pathways, the tumoral microenvironment, and host-immune system evasion in cHL.https://www.mdpi.com/1422-0067/21/18/6623classical Hodgkin lymphomaHodgkin cellsReed–Sternberg cellsgenetic instabilitytelomere dysfunctionshelterin |
| spellingShingle | Marc Bienz Salima Ramdani Hans Knecht Molecular Pathogenesis of Hodgkin Lymphoma: Past, Present, Future International Journal of Molecular Sciences classical Hodgkin lymphoma Hodgkin cells Reed–Sternberg cells genetic instability telomere dysfunction shelterin |
| title | Molecular Pathogenesis of Hodgkin Lymphoma: Past, Present, Future |
| title_full | Molecular Pathogenesis of Hodgkin Lymphoma: Past, Present, Future |
| title_fullStr | Molecular Pathogenesis of Hodgkin Lymphoma: Past, Present, Future |
| title_full_unstemmed | Molecular Pathogenesis of Hodgkin Lymphoma: Past, Present, Future |
| title_short | Molecular Pathogenesis of Hodgkin Lymphoma: Past, Present, Future |
| title_sort | molecular pathogenesis of hodgkin lymphoma past present future |
| topic | classical Hodgkin lymphoma Hodgkin cells Reed–Sternberg cells genetic instability telomere dysfunction shelterin |
| url | https://www.mdpi.com/1422-0067/21/18/6623 |
| work_keys_str_mv | AT marcbienz molecularpathogenesisofhodgkinlymphomapastpresentfuture AT salimaramdani molecularpathogenesisofhodgkinlymphomapastpresentfuture AT hansknecht molecularpathogenesisofhodgkinlymphomapastpresentfuture |