Recombinant Costimulatory Fusion Proteins as Functional Immunomodulators Enhance Antitumor Activity in Murine B16F10 Melanoma

Recombinant Costimulatory Fusion Proteins as Functional Immunomodulators Enhance Antitumor Activity in Murine B16F10 Melanoma

Blocking inhibitory signaling and engaging stimulatory signaling have emerged as important therapeutic modalities for cancer immunotherapy. This study aimed to investigate immunomodulatory features of three recombinant costimulatory ligand proteins in a mouse model, which are extracellular domains o...

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Bibliographic Details
Main Authors: Huaman Cai, Wenfang Wang, Zhibing Lin, Yan Zhang, Bing Wu, Yuhua Wan, Rongxiu Li
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Vaccines
Subjects:
cancer immunotherapy
OX40L
4-1BBL
immunomodulator
tumor microenvironment
Online Access:https://www.mdpi.com/2076-393X/8/2/223

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