Sole adjuvant intraoperative breast radiotherapy in Taiwan: a single-center experience
Abstract Introduction Intraoperative radiotherapy (IORT) is more convenient than standard whole breast external beam radiotherapy (EBRT) as a sole adjuvant radiotherapy for breast cancer. The impact of age on breast cancer course and treatment strategy is still under investigation, and the peak age...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-04-01
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| Series: | Breast Cancer Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13058-021-01421-y |
| _version_ | 1818566584711512064 |
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| author | Hsin-Yi Yang Chi-Wen Tu Chien-Chin Chen Cheng-Yen Lee Yu-Chen Hsu |
| author_facet | Hsin-Yi Yang Chi-Wen Tu Chien-Chin Chen Cheng-Yen Lee Yu-Chen Hsu |
| author_sort | Hsin-Yi Yang |
| collection | DOAJ |
| description | Abstract Introduction Intraoperative radiotherapy (IORT) is more convenient than standard whole breast external beam radiotherapy (EBRT) as a sole adjuvant radiotherapy for breast cancer. The impact of age on breast cancer course and treatment strategy is still under investigation, and the peak age for breast cancer in Taiwan is much younger than that in Western countries. We aimed to review the oncological outcomes of sole IORT compared with standard EBRT in a country with younger breast cancer patients. Patients and methods We reviewed patients with invasive breast cancer who received breast-conserving surgery (BCS) from September 2014 to December 2016. The clinicopathologic characteristics and oncological outcomes of eligible patients who received EBRT or IORT as sole adjuvant radiotherapy after BCS were collected and reviewed. Results A total of 170 patients were enrolled with a mean follow-up time of 3.53 ± 0.82 years. The risk of locoregional recurrence was 2.44% for EBRT versus 10.64% for IORT (p = 0.024). IORT was a significant risk factor of locoregional recurrence (p = 0.005). The hazard ratios (HRs) for locoregional recurrence in the IORT group compared with the EBRT group were significantly higher in non-suitable risk group patients (HR = 7.02, p = 0.009) and in patients under 50 years old (HR = 10.42, p = 0.011). Conclusions Locoregional recurrence was significantly higher in patients who received IORT than in those who underwent EBRT. IORT should not be used alone in patients under 50 years old who do not belong to a suitable group. |
| first_indexed | 2024-12-14T01:55:36Z |
| format | Article |
| id | doaj.art-538f71f77c3744d8b7f19f6fa77813ba |
| institution | Directory Open Access Journal |
| issn | 1465-542X |
| language | English |
| last_indexed | 2024-12-14T01:55:36Z |
| publishDate | 2021-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Breast Cancer Research |
| spelling | doaj.art-538f71f77c3744d8b7f19f6fa77813ba2022-12-21T23:21:12ZengBMCBreast Cancer Research1465-542X2021-04-0123111010.1186/s13058-021-01421-ySole adjuvant intraoperative breast radiotherapy in Taiwan: a single-center experienceHsin-Yi Yang0Chi-Wen Tu1Chien-Chin Chen2Cheng-Yen Lee3Yu-Chen Hsu4Clinical Medicine Research Center, Ditmansion Medical Foundation Chia-Yi Christian HospitalDepartment of Surgery, Ditmansion Medical Foundation Chia-Yi Christian HospitalDepartment of Pathology, Ditmanson Medical Foundation Chia-Yi Christian HospitalDepartment of Radiation Therapy and Oncology, Ditmanson Medical Foundation Chia-Yi Christian HospitalDepartment of Surgery, Ditmansion Medical Foundation Chia-Yi Christian HospitalAbstract Introduction Intraoperative radiotherapy (IORT) is more convenient than standard whole breast external beam radiotherapy (EBRT) as a sole adjuvant radiotherapy for breast cancer. The impact of age on breast cancer course and treatment strategy is still under investigation, and the peak age for breast cancer in Taiwan is much younger than that in Western countries. We aimed to review the oncological outcomes of sole IORT compared with standard EBRT in a country with younger breast cancer patients. Patients and methods We reviewed patients with invasive breast cancer who received breast-conserving surgery (BCS) from September 2014 to December 2016. The clinicopathologic characteristics and oncological outcomes of eligible patients who received EBRT or IORT as sole adjuvant radiotherapy after BCS were collected and reviewed. Results A total of 170 patients were enrolled with a mean follow-up time of 3.53 ± 0.82 years. The risk of locoregional recurrence was 2.44% for EBRT versus 10.64% for IORT (p = 0.024). IORT was a significant risk factor of locoregional recurrence (p = 0.005). The hazard ratios (HRs) for locoregional recurrence in the IORT group compared with the EBRT group were significantly higher in non-suitable risk group patients (HR = 7.02, p = 0.009) and in patients under 50 years old (HR = 10.42, p = 0.011). Conclusions Locoregional recurrence was significantly higher in patients who received IORT than in those who underwent EBRT. IORT should not be used alone in patients under 50 years old who do not belong to a suitable group.https://doi.org/10.1186/s13058-021-01421-yBreast cancerIntraoperative radiotherapyWhole breast external beam radiotherapy |
| spellingShingle | Hsin-Yi Yang Chi-Wen Tu Chien-Chin Chen Cheng-Yen Lee Yu-Chen Hsu Sole adjuvant intraoperative breast radiotherapy in Taiwan: a single-center experience Breast Cancer Research Breast cancer Intraoperative radiotherapy Whole breast external beam radiotherapy |
| title | Sole adjuvant intraoperative breast radiotherapy in Taiwan: a single-center experience |
| title_full | Sole adjuvant intraoperative breast radiotherapy in Taiwan: a single-center experience |
| title_fullStr | Sole adjuvant intraoperative breast radiotherapy in Taiwan: a single-center experience |
| title_full_unstemmed | Sole adjuvant intraoperative breast radiotherapy in Taiwan: a single-center experience |
| title_short | Sole adjuvant intraoperative breast radiotherapy in Taiwan: a single-center experience |
| title_sort | sole adjuvant intraoperative breast radiotherapy in taiwan a single center experience |
| topic | Breast cancer Intraoperative radiotherapy Whole breast external beam radiotherapy |
| url | https://doi.org/10.1186/s13058-021-01421-y |
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