The molecular signature of BCR::ABLP210 and BCR::ABLT315I in a Drosophila melanogaster chronic myeloid leukemia model

The molecular signature of BCR::ABLP210 and BCR::ABLT315I in a Drosophila melanogaster chronic myeloid leukemia model

Summary: Chronic myeloid leukemia (CML) is a clonal hematopoietic stem cell disorder resulting from a balanced translocation leading to BCR::ABL1 oncogene with increased tyrosine kinase activity. Despite the advancements in the development of tyrosine kinase inhibitors (TKIs), the T315I gatekeeper p...

Full description

Bibliographic Details
Main Authors: Amro Baassiri, Ali Ghais, Abdallah Kurdi, Elias Rahal, Rihab Nasr, Margret Shirinian
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:iScience
Subjects:
Molecular biology
Cancer
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224007600

Internet

http://www.sciencedirect.com/science/article/pii/S2589004224007600

Similar Items