NanoBubble-Mediated Oxygenation: Elucidating the Underlying Molecular Mechanisms in Hypoxia and Mitochondrial-Related Pathologies
Worldwide, hypoxia-related conditions, including cancer, COVID-19, and neuro-degenerative diseases, often lead to multi-organ failure and significant mortality. Oxygen, crucial for cellular function, becomes scarce as levels drop below 10 mmHg (<2% O<sub>2</sub>), triggering mitochond...
| मुख्य लेखकों: | , , , |
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| स्वरूप: | लेख |
| भाषा: | English |
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MDPI AG
2023-11-01
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| श्रृंखला: | Nanomaterials |
| विषय: | |
| ऑनलाइन पहुंच: | https://www.mdpi.com/2079-4991/13/23/3060 |
| _version_ | 1827592170516774912 |
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| author | Sergio M. Viafara Garcia Muhammad Saad Khan Ziyad S. Haidar Juan Pablo Acevedo Cox |
| author_facet | Sergio M. Viafara Garcia Muhammad Saad Khan Ziyad S. Haidar Juan Pablo Acevedo Cox |
| author_sort | Sergio M. Viafara Garcia |
| collection | DOAJ |
| description | Worldwide, hypoxia-related conditions, including cancer, COVID-19, and neuro-degenerative diseases, often lead to multi-organ failure and significant mortality. Oxygen, crucial for cellular function, becomes scarce as levels drop below 10 mmHg (<2% O<sub>2</sub>), triggering mitochondrial dysregulation and activating hypoxia-induced factors (HiFs). Herein, oxygen nanobubbles (OnB), an <i>emerging</i> versatile oxygen delivery platform, offer a novel approach to address hypoxia-related pathologies. This review explores OnB oxygen delivery strategies and systems, including diffusion, ultrasound, photodynamic, and pH-responsive nanobubbles. It delves into the nanoscale mechanisms of OnB, elucidating their role in mitochondrial metabolism (TFAM, PGC1alpha), hypoxic responses (HiF-1alpha), and their interplay in chronic pathologies including cancer and neurodegenerative disorders, amongst others. By understanding these dynamics and underlying mechanisms, this article aims to contribute to our accruing knowledge of OnB and the developing potential in ameliorating hypoxia- and metabolic stress-related conditions and fostering innovative therapies. |
| first_indexed | 2024-03-09T01:44:53Z |
| format | Article |
| id | doaj.art-53919bb4c7e74c0191928d43eb215205 |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-09T01:44:53Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-53919bb4c7e74c0191928d43eb2152052023-12-08T15:23:03ZengMDPI AGNanomaterials2079-49912023-11-011323306010.3390/nano13233060NanoBubble-Mediated Oxygenation: Elucidating the Underlying Molecular Mechanisms in Hypoxia and Mitochondrial-Related PathologiesSergio M. Viafara Garcia0Muhammad Saad Khan1Ziyad S. Haidar2Juan Pablo Acevedo Cox3Programa de Doctorado en BioMedicina, School of Medicine, Universidad de los Andes, Santiago 8150513, ChileDepartment of Physics, Toronto Metropolitan University, Toronto, ON M5B 2K3, CanadaPrograma de Doctorado en BioMedicina, School of Medicine, Universidad de los Andes, Santiago 8150513, ChilePrograma de Doctorado en BioMedicina, School of Medicine, Universidad de los Andes, Santiago 8150513, ChileWorldwide, hypoxia-related conditions, including cancer, COVID-19, and neuro-degenerative diseases, often lead to multi-organ failure and significant mortality. Oxygen, crucial for cellular function, becomes scarce as levels drop below 10 mmHg (<2% O<sub>2</sub>), triggering mitochondrial dysregulation and activating hypoxia-induced factors (HiFs). Herein, oxygen nanobubbles (OnB), an <i>emerging</i> versatile oxygen delivery platform, offer a novel approach to address hypoxia-related pathologies. This review explores OnB oxygen delivery strategies and systems, including diffusion, ultrasound, photodynamic, and pH-responsive nanobubbles. It delves into the nanoscale mechanisms of OnB, elucidating their role in mitochondrial metabolism (TFAM, PGC1alpha), hypoxic responses (HiF-1alpha), and their interplay in chronic pathologies including cancer and neurodegenerative disorders, amongst others. By understanding these dynamics and underlying mechanisms, this article aims to contribute to our accruing knowledge of OnB and the developing potential in ameliorating hypoxia- and metabolic stress-related conditions and fostering innovative therapies.https://www.mdpi.com/2079-4991/13/23/3060oxygennanobubbleshypoxiamitochondriametabolismmolecular |
| spellingShingle | Sergio M. Viafara Garcia Muhammad Saad Khan Ziyad S. Haidar Juan Pablo Acevedo Cox NanoBubble-Mediated Oxygenation: Elucidating the Underlying Molecular Mechanisms in Hypoxia and Mitochondrial-Related Pathologies Nanomaterials oxygen nanobubbles hypoxia mitochondria metabolism molecular |
| title | NanoBubble-Mediated Oxygenation: Elucidating the Underlying Molecular Mechanisms in Hypoxia and Mitochondrial-Related Pathologies |
| title_full | NanoBubble-Mediated Oxygenation: Elucidating the Underlying Molecular Mechanisms in Hypoxia and Mitochondrial-Related Pathologies |
| title_fullStr | NanoBubble-Mediated Oxygenation: Elucidating the Underlying Molecular Mechanisms in Hypoxia and Mitochondrial-Related Pathologies |
| title_full_unstemmed | NanoBubble-Mediated Oxygenation: Elucidating the Underlying Molecular Mechanisms in Hypoxia and Mitochondrial-Related Pathologies |
| title_short | NanoBubble-Mediated Oxygenation: Elucidating the Underlying Molecular Mechanisms in Hypoxia and Mitochondrial-Related Pathologies |
| title_sort | nanobubble mediated oxygenation elucidating the underlying molecular mechanisms in hypoxia and mitochondrial related pathologies |
| topic | oxygen nanobubbles hypoxia mitochondria metabolism molecular |
| url | https://www.mdpi.com/2079-4991/13/23/3060 |
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