The potential applications of artificially modified exosomes derived from mesenchymal stem cells in tumor therapy
Mesenchymal stem cells (MSCs) have tumor-homing ability and play critical roles in tumor treatment, but their dual influences on tumor progression limit their therapeutic applications. Exosomes derived from MSCs (MSC-exosomes) exhibit great potential in targeted tumor treatment due to their advantag...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2024-01-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1299384/full |
| _version_ | 1797366487160193024 |
|---|---|
| author | Yilin Song Yilin Song Yilin Song Quanlin Song Daosheng Hu Daosheng Hu Daosheng Hu Binwen Sun Binwen Sun Binwen Sun Mingwei Gao Mingwei Gao Mingwei Gao Xiangnan Liang Xiangnan Liang Xiangnan Liang Boxin Qu Boxin Qu Boxin Qu Lida Suo Lida Suo Lida Suo Zeli Yin Zeli Yin Zeli Yin Liming Wang Liming Wang Liming Wang |
| author_facet | Yilin Song Yilin Song Yilin Song Quanlin Song Daosheng Hu Daosheng Hu Daosheng Hu Binwen Sun Binwen Sun Binwen Sun Mingwei Gao Mingwei Gao Mingwei Gao Xiangnan Liang Xiangnan Liang Xiangnan Liang Boxin Qu Boxin Qu Boxin Qu Lida Suo Lida Suo Lida Suo Zeli Yin Zeli Yin Zeli Yin Liming Wang Liming Wang Liming Wang |
| author_sort | Yilin Song |
| collection | DOAJ |
| description | Mesenchymal stem cells (MSCs) have tumor-homing ability and play critical roles in tumor treatment, but their dual influences on tumor progression limit their therapeutic applications. Exosomes derived from MSCs (MSC-exosomes) exhibit great potential in targeted tumor treatment due to their advantages of high stability, low immunogenicity, good biocompatibility, long circulation time and homing characteristics. Furthermore, the artificial modification of MSC-exosomes could amplify their advantages and their inhibitory effect on tumors and could overcome the limit of tumor-promoting effect. In this review, we summarize the latest therapeutic strategies involving artificially modified MSC-exosomes in tumor treatment, including employing these exosomes as nanomaterials to carry noncoding RNAs or their inhibitors and anticancer drugs, and genetic engineering modification of MSC-exosomes. We also discuss the feasibility of utilizing artificially modified MSC-exosomes as an emerging cell-free method for tumor treatment and related challenges. |
| first_indexed | 2024-03-08T17:05:50Z |
| format | Article |
| id | doaj.art-53923d11fb8245e8b350fd3024d5d49a |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-08T17:05:50Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-53923d11fb8245e8b350fd3024d5d49a2024-01-04T05:06:37ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2024-01-011310.3389/fonc.2023.12993841299384The potential applications of artificially modified exosomes derived from mesenchymal stem cells in tumor therapyYilin Song0Yilin Song1Yilin Song2Quanlin Song3Daosheng Hu4Daosheng Hu5Daosheng Hu6Binwen Sun7Binwen Sun8Binwen Sun9Mingwei Gao10Mingwei Gao11Mingwei Gao12Xiangnan Liang13Xiangnan Liang14Xiangnan Liang15Boxin Qu16Boxin Qu17Boxin Qu18Lida Suo19Lida Suo20Lida Suo21Zeli Yin22Zeli Yin23Zeli Yin24Liming Wang25Liming Wang26Liming Wang27Engineering Research Center for New Materials and Precision Treatment Technology of Malignant Tumors Therapy, The Second Affiliated Hospital of Dalian Medical University, Dalian, ChinaEngineering Technology Research Center for Translational Medicine, The Second Affiliated Hospital of Dalian Medical University, Dalian, ChinaDivision of Hepatobiliary and Pancreatic Surgery, Department of General Surgery, The Second Affiliated Hospital of Dalian Medical University, Dalian, ChinaDepartment of Neurosurgery, The Second Affiliated Hospital of Dalian Medical University, Dalian, ChinaEngineering Research Center for New Materials and Precision Treatment Technology of Malignant Tumors Therapy, The Second Affiliated Hospital of Dalian Medical University, Dalian, ChinaEngineering Technology Research Center for Translational Medicine, The Second Affiliated Hospital of Dalian Medical University, Dalian, ChinaDivision of Hepatobiliary and Pancreatic Surgery, Department of General Surgery, The Second Affiliated Hospital of Dalian Medical University, Dalian, ChinaEngineering Research Center for New Materials and Precision Treatment Technology of Malignant Tumors Therapy, The Second Affiliated Hospital of Dalian Medical University, Dalian, ChinaEngineering Technology Research Center for Translational Medicine, The Second Affiliated Hospital of Dalian Medical University, Dalian, ChinaDivision of Hepatobiliary and Pancreatic Surgery, Department of General Surgery, The Second Affiliated Hospital of Dalian Medical University, Dalian, ChinaEngineering Research Center for New Materials and Precision Treatment Technology of Malignant Tumors Therapy, The Second Affiliated Hospital of Dalian Medical University, Dalian, ChinaEngineering Technology Research Center for Translational Medicine, The Second Affiliated Hospital of Dalian Medical University, Dalian, ChinaDivision of Hepatobiliary and Pancreatic Surgery, Department of General Surgery, The Second Affiliated Hospital of Dalian Medical University, Dalian, ChinaEngineering Research Center for New Materials and Precision Treatment Technology of Malignant Tumors Therapy, The Second Affiliated Hospital of Dalian Medical University, Dalian, ChinaEngineering Technology Research Center for Translational Medicine, The Second Affiliated Hospital of Dalian Medical University, Dalian, ChinaDivision of Hepatobiliary and Pancreatic Surgery, Department of General Surgery, The Second Affiliated Hospital of Dalian Medical University, Dalian, ChinaEngineering Research Center for New Materials and Precision Treatment Technology of Malignant Tumors Therapy, The Second Affiliated Hospital of Dalian Medical University, Dalian, ChinaEngineering Technology Research Center for Translational Medicine, The Second Affiliated Hospital of Dalian Medical University, Dalian, ChinaDivision of Hepatobiliary and Pancreatic Surgery, Department of General Surgery, The Second Affiliated Hospital of Dalian Medical University, Dalian, ChinaEngineering Research Center for New Materials and Precision Treatment Technology of Malignant Tumors Therapy, The Second Affiliated Hospital of Dalian Medical University, Dalian, ChinaEngineering Technology Research Center for Translational Medicine, The Second Affiliated Hospital of Dalian Medical University, Dalian, ChinaDivision of Hepatobiliary and Pancreatic Surgery, Department of General Surgery, The Second Affiliated Hospital of Dalian Medical University, Dalian, ChinaEngineering Research Center for New Materials and Precision Treatment Technology of Malignant Tumors Therapy, The Second Affiliated Hospital of Dalian Medical University, Dalian, ChinaEngineering Technology Research Center for Translational Medicine, The Second Affiliated Hospital of Dalian Medical University, Dalian, ChinaDivision of Hepatobiliary and Pancreatic Surgery, Department of General Surgery, The Second Affiliated Hospital of Dalian Medical University, Dalian, ChinaEngineering Research Center for New Materials and Precision Treatment Technology of Malignant Tumors Therapy, The Second Affiliated Hospital of Dalian Medical University, Dalian, ChinaEngineering Technology Research Center for Translational Medicine, The Second Affiliated Hospital of Dalian Medical University, Dalian, ChinaDivision of Hepatobiliary and Pancreatic Surgery, Department of General Surgery, The Second Affiliated Hospital of Dalian Medical University, Dalian, ChinaMesenchymal stem cells (MSCs) have tumor-homing ability and play critical roles in tumor treatment, but their dual influences on tumor progression limit their therapeutic applications. Exosomes derived from MSCs (MSC-exosomes) exhibit great potential in targeted tumor treatment due to their advantages of high stability, low immunogenicity, good biocompatibility, long circulation time and homing characteristics. Furthermore, the artificial modification of MSC-exosomes could amplify their advantages and their inhibitory effect on tumors and could overcome the limit of tumor-promoting effect. In this review, we summarize the latest therapeutic strategies involving artificially modified MSC-exosomes in tumor treatment, including employing these exosomes as nanomaterials to carry noncoding RNAs or their inhibitors and anticancer drugs, and genetic engineering modification of MSC-exosomes. We also discuss the feasibility of utilizing artificially modified MSC-exosomes as an emerging cell-free method for tumor treatment and related challenges.https://www.frontiersin.org/articles/10.3389/fonc.2023.1299384/fullmesenchymal stem cellsexosomestumor-targeted therapyanti-cancerdrug delivery |
| spellingShingle | Yilin Song Yilin Song Yilin Song Quanlin Song Daosheng Hu Daosheng Hu Daosheng Hu Binwen Sun Binwen Sun Binwen Sun Mingwei Gao Mingwei Gao Mingwei Gao Xiangnan Liang Xiangnan Liang Xiangnan Liang Boxin Qu Boxin Qu Boxin Qu Lida Suo Lida Suo Lida Suo Zeli Yin Zeli Yin Zeli Yin Liming Wang Liming Wang Liming Wang The potential applications of artificially modified exosomes derived from mesenchymal stem cells in tumor therapy Frontiers in Oncology mesenchymal stem cells exosomes tumor-targeted therapy anti-cancer drug delivery |
| title | The potential applications of artificially modified exosomes derived from mesenchymal stem cells in tumor therapy |
| title_full | The potential applications of artificially modified exosomes derived from mesenchymal stem cells in tumor therapy |
| title_fullStr | The potential applications of artificially modified exosomes derived from mesenchymal stem cells in tumor therapy |
| title_full_unstemmed | The potential applications of artificially modified exosomes derived from mesenchymal stem cells in tumor therapy |
| title_short | The potential applications of artificially modified exosomes derived from mesenchymal stem cells in tumor therapy |
| title_sort | potential applications of artificially modified exosomes derived from mesenchymal stem cells in tumor therapy |
| topic | mesenchymal stem cells exosomes tumor-targeted therapy anti-cancer drug delivery |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1299384/full |
| work_keys_str_mv | AT yilinsong thepotentialapplicationsofartificiallymodifiedexosomesderivedfrommesenchymalstemcellsintumortherapy AT yilinsong thepotentialapplicationsofartificiallymodifiedexosomesderivedfrommesenchymalstemcellsintumortherapy AT yilinsong thepotentialapplicationsofartificiallymodifiedexosomesderivedfrommesenchymalstemcellsintumortherapy AT quanlinsong thepotentialapplicationsofartificiallymodifiedexosomesderivedfrommesenchymalstemcellsintumortherapy AT daoshenghu thepotentialapplicationsofartificiallymodifiedexosomesderivedfrommesenchymalstemcellsintumortherapy AT daoshenghu thepotentialapplicationsofartificiallymodifiedexosomesderivedfrommesenchymalstemcellsintumortherapy AT daoshenghu thepotentialapplicationsofartificiallymodifiedexosomesderivedfrommesenchymalstemcellsintumortherapy AT binwensun thepotentialapplicationsofartificiallymodifiedexosomesderivedfrommesenchymalstemcellsintumortherapy AT binwensun thepotentialapplicationsofartificiallymodifiedexosomesderivedfrommesenchymalstemcellsintumortherapy AT binwensun thepotentialapplicationsofartificiallymodifiedexosomesderivedfrommesenchymalstemcellsintumortherapy AT mingweigao thepotentialapplicationsofartificiallymodifiedexosomesderivedfrommesenchymalstemcellsintumortherapy AT mingweigao thepotentialapplicationsofartificiallymodifiedexosomesderivedfrommesenchymalstemcellsintumortherapy AT mingweigao thepotentialapplicationsofartificiallymodifiedexosomesderivedfrommesenchymalstemcellsintumortherapy AT xiangnanliang thepotentialapplicationsofartificiallymodifiedexosomesderivedfrommesenchymalstemcellsintumortherapy AT xiangnanliang thepotentialapplicationsofartificiallymodifiedexosomesderivedfrommesenchymalstemcellsintumortherapy AT xiangnanliang thepotentialapplicationsofartificiallymodifiedexosomesderivedfrommesenchymalstemcellsintumortherapy AT boxinqu thepotentialapplicationsofartificiallymodifiedexosomesderivedfrommesenchymalstemcellsintumortherapy AT boxinqu thepotentialapplicationsofartificiallymodifiedexosomesderivedfrommesenchymalstemcellsintumortherapy AT boxinqu thepotentialapplicationsofartificiallymodifiedexosomesderivedfrommesenchymalstemcellsintumortherapy AT lidasuo thepotentialapplicationsofartificiallymodifiedexosomesderivedfrommesenchymalstemcellsintumortherapy AT lidasuo thepotentialapplicationsofartificiallymodifiedexosomesderivedfrommesenchymalstemcellsintumortherapy AT lidasuo thepotentialapplicationsofartificiallymodifiedexosomesderivedfrommesenchymalstemcellsintumortherapy AT zeliyin thepotentialapplicationsofartificiallymodifiedexosomesderivedfrommesenchymalstemcellsintumortherapy AT zeliyin thepotentialapplicationsofartificiallymodifiedexosomesderivedfrommesenchymalstemcellsintumortherapy AT zeliyin thepotentialapplicationsofartificiallymodifiedexosomesderivedfrommesenchymalstemcellsintumortherapy AT limingwang thepotentialapplicationsofartificiallymodifiedexosomesderivedfrommesenchymalstemcellsintumortherapy AT limingwang thepotentialapplicationsofartificiallymodifiedexosomesderivedfrommesenchymalstemcellsintumortherapy AT limingwang thepotentialapplicationsofartificiallymodifiedexosomesderivedfrommesenchymalstemcellsintumortherapy AT yilinsong potentialapplicationsofartificiallymodifiedexosomesderivedfrommesenchymalstemcellsintumortherapy AT yilinsong potentialapplicationsofartificiallymodifiedexosomesderivedfrommesenchymalstemcellsintumortherapy AT yilinsong potentialapplicationsofartificiallymodifiedexosomesderivedfrommesenchymalstemcellsintumortherapy AT quanlinsong potentialapplicationsofartificiallymodifiedexosomesderivedfrommesenchymalstemcellsintumortherapy AT daoshenghu potentialapplicationsofartificiallymodifiedexosomesderivedfrommesenchymalstemcellsintumortherapy AT daoshenghu potentialapplicationsofartificiallymodifiedexosomesderivedfrommesenchymalstemcellsintumortherapy AT daoshenghu potentialapplicationsofartificiallymodifiedexosomesderivedfrommesenchymalstemcellsintumortherapy AT binwensun potentialapplicationsofartificiallymodifiedexosomesderivedfrommesenchymalstemcellsintumortherapy AT binwensun potentialapplicationsofartificiallymodifiedexosomesderivedfrommesenchymalstemcellsintumortherapy AT binwensun potentialapplicationsofartificiallymodifiedexosomesderivedfrommesenchymalstemcellsintumortherapy AT mingweigao potentialapplicationsofartificiallymodifiedexosomesderivedfrommesenchymalstemcellsintumortherapy AT mingweigao potentialapplicationsofartificiallymodifiedexosomesderivedfrommesenchymalstemcellsintumortherapy AT mingweigao potentialapplicationsofartificiallymodifiedexosomesderivedfrommesenchymalstemcellsintumortherapy AT xiangnanliang potentialapplicationsofartificiallymodifiedexosomesderivedfrommesenchymalstemcellsintumortherapy AT xiangnanliang potentialapplicationsofartificiallymodifiedexosomesderivedfrommesenchymalstemcellsintumortherapy AT xiangnanliang potentialapplicationsofartificiallymodifiedexosomesderivedfrommesenchymalstemcellsintumortherapy AT boxinqu potentialapplicationsofartificiallymodifiedexosomesderivedfrommesenchymalstemcellsintumortherapy AT boxinqu potentialapplicationsofartificiallymodifiedexosomesderivedfrommesenchymalstemcellsintumortherapy AT boxinqu potentialapplicationsofartificiallymodifiedexosomesderivedfrommesenchymalstemcellsintumortherapy AT lidasuo potentialapplicationsofartificiallymodifiedexosomesderivedfrommesenchymalstemcellsintumortherapy AT lidasuo potentialapplicationsofartificiallymodifiedexosomesderivedfrommesenchymalstemcellsintumortherapy AT lidasuo potentialapplicationsofartificiallymodifiedexosomesderivedfrommesenchymalstemcellsintumortherapy AT zeliyin potentialapplicationsofartificiallymodifiedexosomesderivedfrommesenchymalstemcellsintumortherapy AT zeliyin potentialapplicationsofartificiallymodifiedexosomesderivedfrommesenchymalstemcellsintumortherapy AT zeliyin potentialapplicationsofartificiallymodifiedexosomesderivedfrommesenchymalstemcellsintumortherapy AT limingwang potentialapplicationsofartificiallymodifiedexosomesderivedfrommesenchymalstemcellsintumortherapy AT limingwang potentialapplicationsofartificiallymodifiedexosomesderivedfrommesenchymalstemcellsintumortherapy AT limingwang potentialapplicationsofartificiallymodifiedexosomesderivedfrommesenchymalstemcellsintumortherapy |