Pharmacokinetics of BPA in gliomas with ultrasound induced blood-brain barrier disruption as measured by microdialysis.
The blood-brain barrier (BBB) can be transiently disrupted by focused ultrasound (FUS) in the presence of microbubbles for targeted drug delivery. Previous studies have illustrated the pharmacokinetics of drug delivery across the BBB after sonication using indirect visualization techniques. In this...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4061112?pdf=render |
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| author | Feng-Yi Yang Yi-Li Lin Fong-In Chou Yu-Chuan Lin Yen-Wan Hsueh Liu Lun-Wei Chang Yu-Ling Hsieh |
| author_facet | Feng-Yi Yang Yi-Li Lin Fong-In Chou Yu-Chuan Lin Yen-Wan Hsueh Liu Lun-Wei Chang Yu-Ling Hsieh |
| author_sort | Feng-Yi Yang |
| collection | DOAJ |
| description | The blood-brain barrier (BBB) can be transiently disrupted by focused ultrasound (FUS) in the presence of microbubbles for targeted drug delivery. Previous studies have illustrated the pharmacokinetics of drug delivery across the BBB after sonication using indirect visualization techniques. In this study, we investigated the in vivo extracellular kinetics of boronophenylalanine-fructose (BPA-f) in glioma-bearing rats with FUS-induced BBB disruption by microdialysis. After simultaneous intravenous administration of BPA and FUS exposure, the boron concentration in the treated brains was quantified by inductively coupled plasma mass spectroscopy. With FUS, the mean peak concentration of BPA-f in the glioma dialysate was 3.6 times greater than without FUS, and the area under the concentration-time curve was 2.1 times greater. This study demonstrates that intracerebral microdialysis can be used to assess local BBB transport profiles of drugs in a sonicated site. Applying microdialysis to the study of metabolism and pharmacokinetics is useful for obtaining selective information within a specific brain site after FUS-induced BBB disruption. |
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| id | doaj.art-5392ae32bda04772ae222f0b4dc13dce |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-12T01:50:16Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
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| spelling | doaj.art-5392ae32bda04772ae222f0b4dc13dce2022-12-22T00:42:30ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0196e10010410.1371/journal.pone.0100104Pharmacokinetics of BPA in gliomas with ultrasound induced blood-brain barrier disruption as measured by microdialysis.Feng-Yi YangYi-Li LinFong-In ChouYu-Chuan LinYen-Wan Hsueh LiuLun-Wei ChangYu-Ling HsiehThe blood-brain barrier (BBB) can be transiently disrupted by focused ultrasound (FUS) in the presence of microbubbles for targeted drug delivery. Previous studies have illustrated the pharmacokinetics of drug delivery across the BBB after sonication using indirect visualization techniques. In this study, we investigated the in vivo extracellular kinetics of boronophenylalanine-fructose (BPA-f) in glioma-bearing rats with FUS-induced BBB disruption by microdialysis. After simultaneous intravenous administration of BPA and FUS exposure, the boron concentration in the treated brains was quantified by inductively coupled plasma mass spectroscopy. With FUS, the mean peak concentration of BPA-f in the glioma dialysate was 3.6 times greater than without FUS, and the area under the concentration-time curve was 2.1 times greater. This study demonstrates that intracerebral microdialysis can be used to assess local BBB transport profiles of drugs in a sonicated site. Applying microdialysis to the study of metabolism and pharmacokinetics is useful for obtaining selective information within a specific brain site after FUS-induced BBB disruption.http://europepmc.org/articles/PMC4061112?pdf=render |
| spellingShingle | Feng-Yi Yang Yi-Li Lin Fong-In Chou Yu-Chuan Lin Yen-Wan Hsueh Liu Lun-Wei Chang Yu-Ling Hsieh Pharmacokinetics of BPA in gliomas with ultrasound induced blood-brain barrier disruption as measured by microdialysis. PLoS ONE |
| title | Pharmacokinetics of BPA in gliomas with ultrasound induced blood-brain barrier disruption as measured by microdialysis. |
| title_full | Pharmacokinetics of BPA in gliomas with ultrasound induced blood-brain barrier disruption as measured by microdialysis. |
| title_fullStr | Pharmacokinetics of BPA in gliomas with ultrasound induced blood-brain barrier disruption as measured by microdialysis. |
| title_full_unstemmed | Pharmacokinetics of BPA in gliomas with ultrasound induced blood-brain barrier disruption as measured by microdialysis. |
| title_short | Pharmacokinetics of BPA in gliomas with ultrasound induced blood-brain barrier disruption as measured by microdialysis. |
| title_sort | pharmacokinetics of bpa in gliomas with ultrasound induced blood brain barrier disruption as measured by microdialysis |
| url | http://europepmc.org/articles/PMC4061112?pdf=render |
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