Contributions of Mass Spectrometry to the Identification of Low Molecular Weight Molecules Able to Reduce the Toxicity of Amyloid-β Peptide to Cell Cultures and Transgenic Mouse Models of Alzheimer’s Disease

Contributions of Mass Spectrometry to the Identification of Low Molecular Weight Molecules Able to Reduce the Toxicity of Amyloid-β Peptide to Cell Cultures and Transgenic Mouse Models of Alzheimer’s Disease

Alzheimer’s Disease affects approximately 33 million people worldwide and is characterized by progressive loss of memory at the cognitive level. The formation of toxic amyloid oligomers, extracellular amyloid plaques and amyloid angiopathy in brain by amyloid beta peptides are considered a...

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Bibliographic Details
Main Authors: Raluca Ştefănescu, Gabriela Dumitriṭa Stanciu, Andrei Luca, Ioana Cezara Caba, Bogdan Ionel Tamba, Cosmin Teodor Mihai
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Molecules
Subjects:
Alzheimer’s Disease
amyloid-β peptides
mass spectrometry
proteolytic enzymes
anti-aggregating compounds
in vitro models
cell viability
transgenic mouse models
cognitive dysfunction
spatial working memory
Online Access:https://www.mdpi.com/1420-3049/24/6/1167

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