Development of a physiologically-based computational kidney model to describe the renal excretion of hydrophilic agents in rats

Development of a physiologically-based computational kidney model to describe the renal excretion of hydrophilic agents in rats

A physiologically-based kidney model was developed to analyze the renal excretion and kidney exposure of hydrophilic agents, in particular contrast media, in rats. In order to study the influence of osmolality and viscosity changes, the model mechanistically represents urine concentration by water r...

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Bibliographic Details
Main Authors: Christoph eNiederalt, Thomas eWendl, Lars eKuepfer, Karina eClaaßen, Roland eLoosen, Stefan eWillmann, Jörg eLippert, Marcus eSchultze-Mosgau, Julia eWinkler, Rolf eBurghaus, Matthias eBräutigam, Hubertus ePietsch, Philipp eLengsfeld
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-01-01
Series:Frontiers in Physiology
Subjects:
Contrast Media
Kidney
Viscosity
simulation
modeling
PBPK
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00494/full

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