Four Eremophilane Sesquiterpenes from the Mangrove Endophytic Fungus Xylaria sp. BL321
Three new eremophilane sesquiterpenes (1–3) were isolated from the mangrove endophytic fungus Xylaria sp. BL321 together with 07H239-A (4), a known analogue of the new compounds. The structures of these compounds were elucidated by analysis of their MS, 1D and 2D NMR spectroscopic data. Compound 4 s...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2012-02-01
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| Series: | Marine Drugs |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1660-3397/10/2/340/ |
| _version_ | 1828368374841737216 |
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| author | Yongcheng Lin Yucheng Gu Lan Liu Yongxiang Song Lin Ma Hongbo Huang Jiajian Wang Jun Wang |
| author_facet | Yongcheng Lin Yucheng Gu Lan Liu Yongxiang Song Lin Ma Hongbo Huang Jiajian Wang Jun Wang |
| author_sort | Yongcheng Lin |
| collection | DOAJ |
| description | Three new eremophilane sesquiterpenes (1–3) were isolated from the mangrove endophytic fungus Xylaria sp. BL321 together with 07H239-A (4), a known analogue of the new compounds. The structures of these compounds were elucidated by analysis of their MS, 1D and 2D NMR spectroscopic data. Compound 4 showed activation activity on α-glucosidase at 0.15 μM (146%), and then, 4 gradually produced inhibitory activity on α-glucosidase with increasing concentration, and the IC50 value is 6.54 μM. |
| first_indexed | 2024-04-14T06:10:16Z |
| format | Article |
| id | doaj.art-539856ea53034daba46ff049b9474d00 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-14T06:10:16Z |
| publishDate | 2012-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-539856ea53034daba46ff049b9474d002022-12-22T02:08:23ZengMDPI AGMarine Drugs1660-33972012-02-0110234034810.3390/md10020340Four Eremophilane Sesquiterpenes from the Mangrove Endophytic Fungus Xylaria sp. BL321Yongcheng LinYucheng GuLan LiuYongxiang SongLin MaHongbo HuangJiajian WangJun WangThree new eremophilane sesquiterpenes (1–3) were isolated from the mangrove endophytic fungus Xylaria sp. BL321 together with 07H239-A (4), a known analogue of the new compounds. The structures of these compounds were elucidated by analysis of their MS, 1D and 2D NMR spectroscopic data. Compound 4 showed activation activity on α-glucosidase at 0.15 μM (146%), and then, 4 gradually produced inhibitory activity on α-glucosidase with increasing concentration, and the IC50 value is 6.54 μM.http://www.mdpi.com/1660-3397/10/2/340/marine fungusXylaria sp.mangrovesesquiterpenesα-glucosidase |
| spellingShingle | Yongcheng Lin Yucheng Gu Lan Liu Yongxiang Song Lin Ma Hongbo Huang Jiajian Wang Jun Wang Four Eremophilane Sesquiterpenes from the Mangrove Endophytic Fungus Xylaria sp. BL321 Marine Drugs marine fungus Xylaria sp. mangrove sesquiterpenes α-glucosidase |
| title | Four Eremophilane Sesquiterpenes from the Mangrove Endophytic Fungus Xylaria sp. BL321 |
| title_full | Four Eremophilane Sesquiterpenes from the Mangrove Endophytic Fungus Xylaria sp. BL321 |
| title_fullStr | Four Eremophilane Sesquiterpenes from the Mangrove Endophytic Fungus Xylaria sp. BL321 |
| title_full_unstemmed | Four Eremophilane Sesquiterpenes from the Mangrove Endophytic Fungus Xylaria sp. BL321 |
| title_short | Four Eremophilane Sesquiterpenes from the Mangrove Endophytic Fungus Xylaria sp. BL321 |
| title_sort | four eremophilane sesquiterpenes from the mangrove endophytic fungus xylaria sp bl321 |
| topic | marine fungus Xylaria sp. mangrove sesquiterpenes α-glucosidase |
| url | http://www.mdpi.com/1660-3397/10/2/340/ |
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