LDLR-related protein 10 (LRP10) regulates amyloid precursor protein (APP) trafficking and processing: evidence for a role in Alzheimer’s disease

LDLR-related protein 10 (LRP10) regulates amyloid precursor protein (APP) trafficking and processing: evidence for a role in Alzheimer’s disease

<p>Abstract</p> <p>Background</p> <p>The Aβ peptide that accumulates in Alzheimer’s disease (AD) is derived from amyloid precursor protein (APP) following proteolysis by β- and γ-secretases. Substantial evidence indicates that alterations in APP trafficking within the s...

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Bibliographic Details
Main Authors: Brodeur Julie, Thériault Caroline, Lessard-Beaudoin Mélissa, Marcil Alexandre, Dahan Sophie, Lavoie Christine
Format: Article
Language:English
Published: BMC 2012-06-01
Series:Molecular Neurodegeneration
Subjects:
LDLR-related protein 10 (LRP10)
Amyloid precursor protein (APP)
Amyloid beta (Aβ)
Intracellular trafficking
Alzheimer’s disease
Endosome
Trans-Golgi network (TGN)
Low density lipoprotein receptor (LDLR)
Online Access:http://www.molecularneurodegeneration.com/content/7/1/31

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