Enhancement of the HIV-1-Specific Immune Response Induced by an mRNA Vaccine through Boosting with a Poxvirus MVA Vector Expressing the Same Antigen

Enhancement of the HIV-1-Specific Immune Response Induced by an mRNA Vaccine through Boosting with a Poxvirus MVA Vector Expressing the Same Antigen

Development of a vaccine against HIV remains a major target goal in the field. The recent success of mRNA vaccines against the coronavirus SARS-CoV-2 is pointing out a new era of vaccine designs against pathogens. Here, we have generated two types of mRNA vaccine candidates against HIV-1; one based...

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Bibliographic Details
Main Authors: Carmen Elena Gómez, Beatriz Perdiguero, Lorena Usero, Laura Marcos-Villar, Laia Miralles, Lorna Leal, Carlos Óscar S. Sorzano, Cristina Sánchez-Corzo, Montserrat Plana, Felipe García, Mariano Esteban
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Vaccines
Subjects:
HIV-1 mRNA vaccines
multiepitopic protein
intranodal delivery
T cells
poxvirus MVA vector
mice
Online Access:https://www.mdpi.com/2076-393X/9/9/959

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