A Humanized Mouse Model for Plasmodium vivax to Test Interventions that Block Liver Stage to Blood Stage Transition and Blood Stage Infection

A Humanized Mouse Model for Plasmodium vivax to Test Interventions that Block Liver Stage to Blood Stage Transition and Blood Stage Infection

Summary: The human malaria parasite Plasmodium vivax remains vastly understudied, mainly due to the lack of suitable laboratory models. Here, we report a humanized mouse model to test interventions that block P. vivax parasite transition from liver stage infection to blood stage infection. Human liv...

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Bibliographic Details
Main Authors: Carola Schäfer, Wanlapa Roobsoong, Niwat Kangwanrangsan, Martino Bardelli, Thomas A. Rawlinson, Nicholas Dambrauskas, Olesya Trakhimets, Chaitra Parthiban, Debashree Goswami, Laura M. Reynolds, Spencer Y. Kennedy, Erika L. Flannery, Sean C. Murphy, D. Noah Sather, Simon J. Draper, Jetsumon Sattabongkot, Sebastian A. Mikolajczak, Stefan H.I. Kappe
Format: Article
Language:English
Published: Elsevier 2020-08-01
Series:iScience
Subjects:
Microbiology
Model Organism
Parasitology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220305691

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