The COVID HOME study research protocol: Prospective cohort study of non-hospitalised COVID-19 patients
<h4>Background</h4> Guidelines on COVID-19 management are developed as we learn from this pandemic. However, most research has been done on hospitalised patients and the impact of the disease on non-hospitalised and their role in transmission are not yet well understood. The COVID HOME s...
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| Language: | English |
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Public Library of Science (PLoS)
2022-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9632784/?tool=EBI |
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| author | Adriana Tami Bernardina T. F. van der Gun Karin I. Wold María F. Vincenti-González Alida C. M. Veloo Marjolein Knoester Valerie P. R. Harmsma Gerolf C. de Boer Anke L. W. Huckriede Daniele Pantano Lilli Gard Izabela A. Rodenhuis-Zybert Vinit Upasani Jolanda Smit Akkelies E. Dijkstra Jacco J. de Haan Jip M. van Elst Jossy van den Boogaard Shennae O’ Boyle Luis Nacul Hubert G. M. Niesters Alex W. Friedrich |
| author_facet | Adriana Tami Bernardina T. F. van der Gun Karin I. Wold María F. Vincenti-González Alida C. M. Veloo Marjolein Knoester Valerie P. R. Harmsma Gerolf C. de Boer Anke L. W. Huckriede Daniele Pantano Lilli Gard Izabela A. Rodenhuis-Zybert Vinit Upasani Jolanda Smit Akkelies E. Dijkstra Jacco J. de Haan Jip M. van Elst Jossy van den Boogaard Shennae O’ Boyle Luis Nacul Hubert G. M. Niesters Alex W. Friedrich |
| author_sort | Adriana Tami |
| collection | DOAJ |
| description | <h4>Background</h4> Guidelines on COVID-19 management are developed as we learn from this pandemic. However, most research has been done on hospitalised patients and the impact of the disease on non-hospitalised and their role in transmission are not yet well understood. The COVID HOME study conducts research among COVID-19 patients and their family members who were not hospitalised during acute disease, to guide patient care and inform public health guidelines for infection prevention and control in the community and household. <h4>Methods</h4> An ongoing prospective longitudinal observational study of COVID-19 outpatients was established in March 2020 at the beginning of the COVID-19 pandemic in the Netherlands. Laboratory confirmed SARS-CoV-2 infected individuals of all ages that did not merit hospitalisation, and their household (HH) members, were enrolled after written informed consent. Enrolled participants were visited at home within 48 hours after initial diagnosis, and then weekly on days 7, 14 and 21 to obtain clinical data, a blood sample for biochemical parameters/cytokines and serological determination; and a nasopharyngeal/throat swab plus urine, stool and sperm or vaginal secretion (if consenting) to test for SARS-CoV-2 by RT-PCR (viral shedding) and for viral culturing. Weekly nasopharyngeal/throat swabs and stool samples, plus a blood sample on days 0 and 21 were also taken from HH members to determine whether and when they became infected. All participants were invited to continue follow-up at 3-, 6-, 12- and 18-months post-infection to assess long-term sequelae and immunological status. |
| first_indexed | 2024-04-11T07:06:49Z |
| format | Article |
| id | doaj.art-539be222ea39407e89bea4f3560a60b1 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-11T07:06:49Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj.art-539be222ea39407e89bea4f3560a60b12022-12-22T04:38:22ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-011711The COVID HOME study research protocol: Prospective cohort study of non-hospitalised COVID-19 patientsAdriana TamiBernardina T. F. van der GunKarin I. WoldMaría F. Vincenti-GonzálezAlida C. M. VelooMarjolein KnoesterValerie P. R. HarmsmaGerolf C. de BoerAnke L. W. HuckriedeDaniele PantanoLilli GardIzabela A. Rodenhuis-ZybertVinit UpasaniJolanda SmitAkkelies E. DijkstraJacco J. de HaanJip M. van ElstJossy van den BoogaardShennae O’ BoyleLuis NaculHubert G. M. NiestersAlex W. Friedrich<h4>Background</h4> Guidelines on COVID-19 management are developed as we learn from this pandemic. However, most research has been done on hospitalised patients and the impact of the disease on non-hospitalised and their role in transmission are not yet well understood. The COVID HOME study conducts research among COVID-19 patients and their family members who were not hospitalised during acute disease, to guide patient care and inform public health guidelines for infection prevention and control in the community and household. <h4>Methods</h4> An ongoing prospective longitudinal observational study of COVID-19 outpatients was established in March 2020 at the beginning of the COVID-19 pandemic in the Netherlands. Laboratory confirmed SARS-CoV-2 infected individuals of all ages that did not merit hospitalisation, and their household (HH) members, were enrolled after written informed consent. Enrolled participants were visited at home within 48 hours after initial diagnosis, and then weekly on days 7, 14 and 21 to obtain clinical data, a blood sample for biochemical parameters/cytokines and serological determination; and a nasopharyngeal/throat swab plus urine, stool and sperm or vaginal secretion (if consenting) to test for SARS-CoV-2 by RT-PCR (viral shedding) and for viral culturing. Weekly nasopharyngeal/throat swabs and stool samples, plus a blood sample on days 0 and 21 were also taken from HH members to determine whether and when they became infected. All participants were invited to continue follow-up at 3-, 6-, 12- and 18-months post-infection to assess long-term sequelae and immunological status.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9632784/?tool=EBI |
| spellingShingle | Adriana Tami Bernardina T. F. van der Gun Karin I. Wold María F. Vincenti-González Alida C. M. Veloo Marjolein Knoester Valerie P. R. Harmsma Gerolf C. de Boer Anke L. W. Huckriede Daniele Pantano Lilli Gard Izabela A. Rodenhuis-Zybert Vinit Upasani Jolanda Smit Akkelies E. Dijkstra Jacco J. de Haan Jip M. van Elst Jossy van den Boogaard Shennae O’ Boyle Luis Nacul Hubert G. M. Niesters Alex W. Friedrich The COVID HOME study research protocol: Prospective cohort study of non-hospitalised COVID-19 patients PLoS ONE |
| title | The COVID HOME study research protocol: Prospective cohort study of non-hospitalised COVID-19 patients |
| title_full | The COVID HOME study research protocol: Prospective cohort study of non-hospitalised COVID-19 patients |
| title_fullStr | The COVID HOME study research protocol: Prospective cohort study of non-hospitalised COVID-19 patients |
| title_full_unstemmed | The COVID HOME study research protocol: Prospective cohort study of non-hospitalised COVID-19 patients |
| title_short | The COVID HOME study research protocol: Prospective cohort study of non-hospitalised COVID-19 patients |
| title_sort | covid home study research protocol prospective cohort study of non hospitalised covid 19 patients |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9632784/?tool=EBI |
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