The impact of influenza vaccination on surgical outcomes in COVID-19 positive patients: An analysis of 43,580 patients.
<h4>Background</h4>Multiple recent studies suggest a possible protective effect of the influenza vaccine against severe acute respiratory coronavirus 2 (SARS-CoV-2). This effect has yet to be evaluated in surgical patients. This study utilizes a continuously updated federated electronic...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2023-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0281990 |
| _version_ | 1797842974882660352 |
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| author | Susan M Taghioff Benjamin R Slavin Shefali Mehra Tripp Holton Devinder Singh |
| author_facet | Susan M Taghioff Benjamin R Slavin Shefali Mehra Tripp Holton Devinder Singh |
| author_sort | Susan M Taghioff |
| collection | DOAJ |
| description | <h4>Background</h4>Multiple recent studies suggest a possible protective effect of the influenza vaccine against severe acute respiratory coronavirus 2 (SARS-CoV-2). This effect has yet to be evaluated in surgical patients. This study utilizes a continuously updated federated electronic medical record (EMR) network (TriNetX, Cambridge, MA) to analyze the influence of the influenza vaccine against post-operative complications in SARS-CoV-2-positive patients.<h4>Methods</h4>The de-identified records of 73,341,020 patients globally were retrospectively screened. Two balanced cohorts totaling 43,580 surgical patients were assessed from January 2020-January 2021. Cohort One received the influenza vaccine six months-two weeks prior to SARS-CoV-2-positive diagnosis, while Cohort Two did not. Post-operative complications within 30, 60, 90, and 120 days of undergoing surgery were analyzed using common procedural terminology(CPT) codes. Outcomes were propensity score matched for characteristics including age, race, gender, diabetes, obesity, and smoking.<h4>Results</h4>SARS-CoV-2-positive patients receiving the influenza vaccine experienced significantly decreased risks of sepsis, deep vein thrombosis, dehiscence, acute myocardial infarction, surgical site infections, and death across multiple time points(p<0.05, Bonferroni Correction p = 0.0011). Number needed to vaccinate (NNV) was calculated for all significant and nominally significant findings.<h4>Conclusion</h4>Our analysis examines the potential protective effect of influenza vaccination in SARS-CoV-2-positive surgical patients. Limitations include this study's retrospective nature and reliance on accuracy of medical coding. Future prospective studies are warranted to confirm our findings. |
| first_indexed | 2024-04-09T16:56:57Z |
| format | Article |
| id | doaj.art-539c526d51b141049b4a38c5fde6bdad |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-09T16:56:57Z |
| publishDate | 2023-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-539c526d51b141049b4a38c5fde6bdad2023-04-21T05:34:57ZengPublic Library of Science (PLoS)PLoS ONE1932-62032023-01-01183e028199010.1371/journal.pone.0281990The impact of influenza vaccination on surgical outcomes in COVID-19 positive patients: An analysis of 43,580 patients.Susan M TaghioffBenjamin R SlavinShefali MehraTripp HoltonDevinder Singh<h4>Background</h4>Multiple recent studies suggest a possible protective effect of the influenza vaccine against severe acute respiratory coronavirus 2 (SARS-CoV-2). This effect has yet to be evaluated in surgical patients. This study utilizes a continuously updated federated electronic medical record (EMR) network (TriNetX, Cambridge, MA) to analyze the influence of the influenza vaccine against post-operative complications in SARS-CoV-2-positive patients.<h4>Methods</h4>The de-identified records of 73,341,020 patients globally were retrospectively screened. Two balanced cohorts totaling 43,580 surgical patients were assessed from January 2020-January 2021. Cohort One received the influenza vaccine six months-two weeks prior to SARS-CoV-2-positive diagnosis, while Cohort Two did not. Post-operative complications within 30, 60, 90, and 120 days of undergoing surgery were analyzed using common procedural terminology(CPT) codes. Outcomes were propensity score matched for characteristics including age, race, gender, diabetes, obesity, and smoking.<h4>Results</h4>SARS-CoV-2-positive patients receiving the influenza vaccine experienced significantly decreased risks of sepsis, deep vein thrombosis, dehiscence, acute myocardial infarction, surgical site infections, and death across multiple time points(p<0.05, Bonferroni Correction p = 0.0011). Number needed to vaccinate (NNV) was calculated for all significant and nominally significant findings.<h4>Conclusion</h4>Our analysis examines the potential protective effect of influenza vaccination in SARS-CoV-2-positive surgical patients. Limitations include this study's retrospective nature and reliance on accuracy of medical coding. Future prospective studies are warranted to confirm our findings.https://doi.org/10.1371/journal.pone.0281990 |
| spellingShingle | Susan M Taghioff Benjamin R Slavin Shefali Mehra Tripp Holton Devinder Singh The impact of influenza vaccination on surgical outcomes in COVID-19 positive patients: An analysis of 43,580 patients. PLoS ONE |
| title | The impact of influenza vaccination on surgical outcomes in COVID-19 positive patients: An analysis of 43,580 patients. |
| title_full | The impact of influenza vaccination on surgical outcomes in COVID-19 positive patients: An analysis of 43,580 patients. |
| title_fullStr | The impact of influenza vaccination on surgical outcomes in COVID-19 positive patients: An analysis of 43,580 patients. |
| title_full_unstemmed | The impact of influenza vaccination on surgical outcomes in COVID-19 positive patients: An analysis of 43,580 patients. |
| title_short | The impact of influenza vaccination on surgical outcomes in COVID-19 positive patients: An analysis of 43,580 patients. |
| title_sort | impact of influenza vaccination on surgical outcomes in covid 19 positive patients an analysis of 43 580 patients |
| url | https://doi.org/10.1371/journal.pone.0281990 |
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