Pharmacokinetic and pharmacodynamic study of triptolide-loaded liposome hydrogel patch under microneedles on rats with collagen-induced arthritis

Pharmacokinetic and pharmacodynamic study of triptolide-loaded liposome hydrogel patch under microneedles on rats with collagen-induced arthritis

Triptolide (TP), a major active component of Tripterygium wilfordii Hook.F. (TWHF), is used to treat rheumatoid arthritis (RA). However, it has a narrow therapeutic window due to its serious toxicities. To increase the therapeutic index, a new triptolide-loaded transdermal delivery system, named tri...

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Bibliographic Details
Main Authors: Gui Chen, Baohua Hao, Dahong Ju, Meijie Liu, Hongyan Zhao, Zhongping Du, Jizi Xia
Format: Article
Language:English
Published: Elsevier 2015-11-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Pharmacokinetics
Pharmacodynamics
Triptolide
Micro-electro-mechanical system
Microneedles
Collagen-induced arthritis
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383515001380

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http://www.sciencedirect.com/science/article/pii/S2211383515001380

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