A Roadmap for the Molecular Farming of Viral Glycoprotein Vaccines: Engineering Glycosylation and Glycosylation-Directed Folding

A Roadmap for the Molecular Farming of Viral Glycoprotein Vaccines: Engineering Glycosylation and Glycosylation-Directed Folding

Immunization with recombinant glycoprotein-based vaccines is a promising approach to induce protective immunity against viruses. However, the complex biosynthetic maturation requirements of these glycoproteins typically necessitate their production in mammalian cells to support their folding and pos...

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Bibliographic Details
Main Authors: Emmanuel Margolin, Max Crispin, Ann Meyers, Ros Chapman, Edward P. Rybicki
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Plant Science
Subjects:
glycosylation
chaperones
calnexin
calreticulin
folding
oligosaccaryltransferase
Online Access:https://www.frontiersin.org/articles/10.3389/fpls.2020.609207/full

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