Resistance training attenuates salt overload-induced cardiac remodeling and diastolic dysfunction in normotensive rats
Elevated salt intake induces changes in the extracellular matrix collagen, leading to myocardial stiffness and impaired relaxation. Resistance training (RT) has been used as a remarkably successful strategy in the treatment of heart disease. Therefore, the aim of this study was to investigate the ef...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Associação Brasileira de Divulgação Científica
|
| Series: | Brazilian Journal of Medical and Biological Research |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000900603&lng=en&tlng=en |
| _version_ | 1818540331856035840 |
|---|---|
| author | D.L.M. Barretti S.F.S. Melo E.M. Oliveira V.G. Barauna |
| author_facet | D.L.M. Barretti S.F.S. Melo E.M. Oliveira V.G. Barauna |
| author_sort | D.L.M. Barretti |
| collection | DOAJ |
| description | Elevated salt intake induces changes in the extracellular matrix collagen, leading to myocardial stiffness and impaired relaxation. Resistance training (RT) has been used as a remarkably successful strategy in the treatment of heart disease. Therefore, the aim of this study was to investigate the effects of RT on preventing pathological adaptation of the left ventricle (LV) induced by salt overload. Male Wistar rats (10 weeks old) were distributed into four groups (n=8/group): control (CO), control+1% salt (CO+SALT), RT and RT+1% salt (RT+SALT). The RT protocol consisted of 4×12 bouts of squat training, 5/week for 8 weeks, with 80% of one repetition maximum (1RM). Echocardiographs were analyzed and interstitial collagen volume fraction (CVF) was determined in the LV. The 1RM tests in the RT and RT+SALT groups increased 145 and 137%, respectively, compared with the test performed before the training program. LV weight-to-body weight ratio and LV weight-to-tibia length ratio were greater in the RT and RT+SALT groups, respectively, compared with the CO group. Although there was no difference in the systolic function between groups, diastolic function decreased 25% in the CO+SALT group compared with the CO group measured by E/A wave ratio. RT partially prevented this decrease in diastolic function compared with the CO+SALT group. A 1% salt overload increased CVF more than 2.4-fold in the CO+SALT group compared with the CO group and RT prevented this increase. In conclusion, RT prevented interstitial collagen deposition in LV rats subjected to 1% NaCl and attenuated diastolic dysfunction induced by salt overload independent of alterations in blood pressure. |
| first_indexed | 2024-12-11T21:53:57Z |
| format | Article |
| id | doaj.art-53a141207c1a45c7a129280f96942bd5 |
| institution | Directory Open Access Journal |
| issn | 1414-431X |
| language | English |
| last_indexed | 2024-12-11T21:53:57Z |
| publisher | Associação Brasileira de Divulgação Científica |
| record_format | Article |
| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-53a141207c1a45c7a129280f96942bd52022-12-22T00:49:23ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research1414-431X50910.1590/1414-431x20176146S0100-879X2017000900603Resistance training attenuates salt overload-induced cardiac remodeling and diastolic dysfunction in normotensive ratsD.L.M. BarrettiS.F.S. MeloE.M. OliveiraV.G. BaraunaElevated salt intake induces changes in the extracellular matrix collagen, leading to myocardial stiffness and impaired relaxation. Resistance training (RT) has been used as a remarkably successful strategy in the treatment of heart disease. Therefore, the aim of this study was to investigate the effects of RT on preventing pathological adaptation of the left ventricle (LV) induced by salt overload. Male Wistar rats (10 weeks old) were distributed into four groups (n=8/group): control (CO), control+1% salt (CO+SALT), RT and RT+1% salt (RT+SALT). The RT protocol consisted of 4×12 bouts of squat training, 5/week for 8 weeks, with 80% of one repetition maximum (1RM). Echocardiographs were analyzed and interstitial collagen volume fraction (CVF) was determined in the LV. The 1RM tests in the RT and RT+SALT groups increased 145 and 137%, respectively, compared with the test performed before the training program. LV weight-to-body weight ratio and LV weight-to-tibia length ratio were greater in the RT and RT+SALT groups, respectively, compared with the CO group. Although there was no difference in the systolic function between groups, diastolic function decreased 25% in the CO+SALT group compared with the CO group measured by E/A wave ratio. RT partially prevented this decrease in diastolic function compared with the CO+SALT group. A 1% salt overload increased CVF more than 2.4-fold in the CO+SALT group compared with the CO group and RT prevented this increase. In conclusion, RT prevented interstitial collagen deposition in LV rats subjected to 1% NaCl and attenuated diastolic dysfunction induced by salt overload independent of alterations in blood pressure.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000900603&lng=en&tlng=enDiastolic dysfunctionInterstitial collagenResistance trainingSalt overload |
| spellingShingle | D.L.M. Barretti S.F.S. Melo E.M. Oliveira V.G. Barauna Resistance training attenuates salt overload-induced cardiac remodeling and diastolic dysfunction in normotensive rats Brazilian Journal of Medical and Biological Research Diastolic dysfunction Interstitial collagen Resistance training Salt overload |
| title | Resistance training attenuates salt overload-induced cardiac remodeling and diastolic dysfunction in normotensive rats |
| title_full | Resistance training attenuates salt overload-induced cardiac remodeling and diastolic dysfunction in normotensive rats |
| title_fullStr | Resistance training attenuates salt overload-induced cardiac remodeling and diastolic dysfunction in normotensive rats |
| title_full_unstemmed | Resistance training attenuates salt overload-induced cardiac remodeling and diastolic dysfunction in normotensive rats |
| title_short | Resistance training attenuates salt overload-induced cardiac remodeling and diastolic dysfunction in normotensive rats |
| title_sort | resistance training attenuates salt overload induced cardiac remodeling and diastolic dysfunction in normotensive rats |
| topic | Diastolic dysfunction Interstitial collagen Resistance training Salt overload |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000900603&lng=en&tlng=en |
| work_keys_str_mv | AT dlmbarretti resistancetrainingattenuatessaltoverloadinducedcardiacremodelinganddiastolicdysfunctioninnormotensiverats AT sfsmelo resistancetrainingattenuatessaltoverloadinducedcardiacremodelinganddiastolicdysfunctioninnormotensiverats AT emoliveira resistancetrainingattenuatessaltoverloadinducedcardiacremodelinganddiastolicdysfunctioninnormotensiverats AT vgbarauna resistancetrainingattenuatessaltoverloadinducedcardiacremodelinganddiastolicdysfunctioninnormotensiverats |