What are the neural correlates of dissociative amnesia? A systematic review of the functional neuroimaging literature
AimDissociative amnesia is an emblematic psychiatric condition in which patients experience massive memory loss ranging from focal to global amnesia. This condition remains poorly understood and this review aims to investigate the neuroanatomical feature of this disease.MethodsWe conducted a systema...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-01-01
|
| Series: | Frontiers in Psychiatry |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1092826/full |
| _version_ | 1828053889891434496 |
|---|---|
| author | Simon Taïb Simon Taïb Antoine Yrondi Antoine Yrondi Béatrice Lemesle Patrice Péran Jérémie Pariente Jérémie Pariente |
| author_facet | Simon Taïb Simon Taïb Antoine Yrondi Antoine Yrondi Béatrice Lemesle Patrice Péran Jérémie Pariente Jérémie Pariente |
| author_sort | Simon Taïb |
| collection | DOAJ |
| description | AimDissociative amnesia is an emblematic psychiatric condition in which patients experience massive memory loss ranging from focal to global amnesia. This condition remains poorly understood and this review aims to investigate the neuroanatomical feature of this disease.MethodsWe conducted a systematic review of the scientific literature available on PubMed, up to December 1, 2022, using a combination of keywords referring to dissociative amnesia. We included every scientific report involving patients undergoing a functional imaging procedure.ResultsTwenty-two studies met our inclusion criteria (gathering 49 patients). Only one was a controlled study with a large sample. The other 21 were case reports and case series. In resting state, neuroimaging studies mostly showed a hypo-activated right inferolateral prefrontal cortex, associated with limbic hypoactivity and lesser activation of the hippocampal and para-hippocampal structures. The patients also presented abnormal patterns of cerebral activation when performing memory tasks. When testing recognition of memories from the amnestic period, patients showed increased activation across temporal areas (hippocampal and para-hippocampal gyri) and the limbic network. When trying to recollect memories from an amnestic period compared to a non-amnestic period, patients failed to activate these structures efficiently. Most of these patterns tended to return to normal when symptoms resolved.ConclusionThis review identified a paucity of controlled studies in the field of dissociative amnesia neuroimaging, which restricts the extrapolation of results. Patients with dissociative amnesia present a broad prefronto-temporo-limbic network dysfunction. Some of the brain areas implicated in this network might represent potential targets for innovative treatments. |
| first_indexed | 2024-04-10T20:14:23Z |
| format | Article |
| id | doaj.art-53a1df0ba9974b79b440d08ab6b42e70 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-04-10T20:14:23Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-53a1df0ba9974b79b440d08ab6b42e702023-01-26T07:43:44ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402023-01-011410.3389/fpsyt.2023.10928261092826What are the neural correlates of dissociative amnesia? A systematic review of the functional neuroimaging literatureSimon Taïb0Simon Taïb1Antoine Yrondi2Antoine Yrondi3Béatrice Lemesle4Patrice Péran5Jérémie Pariente6Jérémie Pariente7INSERM U1214 Centre d’Imagerie Neuro Toulouse (ToNIC), Toulouse, FranceService de Psychiatrie, Psychothérapie et Art-Thérapie, Centre Expert du Stress Traumatique, CHU de Toulouse, Toulouse, FranceINSERM U1214 Centre d’Imagerie Neuro Toulouse (ToNIC), Toulouse, FranceService Universitaire de Psychiatrie et Psychologie Médicale, CHU de Toulouse, Toulouse, FrancePôle Neurosciences, CHU de Toulouse, Toulouse, FranceINSERM U1214 Centre d’Imagerie Neuro Toulouse (ToNIC), Toulouse, FranceINSERM U1214 Centre d’Imagerie Neuro Toulouse (ToNIC), Toulouse, FrancePôle Neurosciences, CHU de Toulouse, Toulouse, FranceAimDissociative amnesia is an emblematic psychiatric condition in which patients experience massive memory loss ranging from focal to global amnesia. This condition remains poorly understood and this review aims to investigate the neuroanatomical feature of this disease.MethodsWe conducted a systematic review of the scientific literature available on PubMed, up to December 1, 2022, using a combination of keywords referring to dissociative amnesia. We included every scientific report involving patients undergoing a functional imaging procedure.ResultsTwenty-two studies met our inclusion criteria (gathering 49 patients). Only one was a controlled study with a large sample. The other 21 were case reports and case series. In resting state, neuroimaging studies mostly showed a hypo-activated right inferolateral prefrontal cortex, associated with limbic hypoactivity and lesser activation of the hippocampal and para-hippocampal structures. The patients also presented abnormal patterns of cerebral activation when performing memory tasks. When testing recognition of memories from the amnestic period, patients showed increased activation across temporal areas (hippocampal and para-hippocampal gyri) and the limbic network. When trying to recollect memories from an amnestic period compared to a non-amnestic period, patients failed to activate these structures efficiently. Most of these patterns tended to return to normal when symptoms resolved.ConclusionThis review identified a paucity of controlled studies in the field of dissociative amnesia neuroimaging, which restricts the extrapolation of results. Patients with dissociative amnesia present a broad prefronto-temporo-limbic network dysfunction. Some of the brain areas implicated in this network might represent potential targets for innovative treatments.https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1092826/fullcognitive disordermemory losshysteriadissociative disorderstresstrauma |
| spellingShingle | Simon Taïb Simon Taïb Antoine Yrondi Antoine Yrondi Béatrice Lemesle Patrice Péran Jérémie Pariente Jérémie Pariente What are the neural correlates of dissociative amnesia? A systematic review of the functional neuroimaging literature Frontiers in Psychiatry cognitive disorder memory loss hysteria dissociative disorder stress trauma |
| title | What are the neural correlates of dissociative amnesia? A systematic review of the functional neuroimaging literature |
| title_full | What are the neural correlates of dissociative amnesia? A systematic review of the functional neuroimaging literature |
| title_fullStr | What are the neural correlates of dissociative amnesia? A systematic review of the functional neuroimaging literature |
| title_full_unstemmed | What are the neural correlates of dissociative amnesia? A systematic review of the functional neuroimaging literature |
| title_short | What are the neural correlates of dissociative amnesia? A systematic review of the functional neuroimaging literature |
| title_sort | what are the neural correlates of dissociative amnesia a systematic review of the functional neuroimaging literature |
| topic | cognitive disorder memory loss hysteria dissociative disorder stress trauma |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1092826/full |
| work_keys_str_mv | AT simontaib whataretheneuralcorrelatesofdissociativeamnesiaasystematicreviewofthefunctionalneuroimagingliterature AT simontaib whataretheneuralcorrelatesofdissociativeamnesiaasystematicreviewofthefunctionalneuroimagingliterature AT antoineyrondi whataretheneuralcorrelatesofdissociativeamnesiaasystematicreviewofthefunctionalneuroimagingliterature AT antoineyrondi whataretheneuralcorrelatesofdissociativeamnesiaasystematicreviewofthefunctionalneuroimagingliterature AT beatricelemesle whataretheneuralcorrelatesofdissociativeamnesiaasystematicreviewofthefunctionalneuroimagingliterature AT patriceperan whataretheneuralcorrelatesofdissociativeamnesiaasystematicreviewofthefunctionalneuroimagingliterature AT jeremiepariente whataretheneuralcorrelatesofdissociativeamnesiaasystematicreviewofthefunctionalneuroimagingliterature AT jeremiepariente whataretheneuralcorrelatesofdissociativeamnesiaasystematicreviewofthefunctionalneuroimagingliterature |