Emerging roles of circular RNAs in retinal diseases
Retinal disorders are a group of ocular diseases whose onset is associated with a number of aberrant molecular and cellular processes or physical damages that affect retinal structure and function resulting in neural and vascular degeneration in the retina. Current research has primarily focused on...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Neural Regeneration Research |
| Subjects: | |
| Online Access: | http://www.nrronline.org/article.asp?issn=1673-5374;year=2022;volume=17;issue=9;spage=1875;epage=1880;aulast=Hanineva |
| _version_ | 1818199483480014848 |
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| author | Aneliya Hanineva Karen Sophia Park Joshua J Wang Margaret M DeAngelis Michael H Farkas Sarah X Zhang |
| author_facet | Aneliya Hanineva Karen Sophia Park Joshua J Wang Margaret M DeAngelis Michael H Farkas Sarah X Zhang |
| author_sort | Aneliya Hanineva |
| collection | DOAJ |
| description | Retinal disorders are a group of ocular diseases whose onset is associated with a number of aberrant molecular and cellular processes or physical damages that affect retinal structure and function resulting in neural and vascular degeneration in the retina. Current research has primarily focused on delaying retinal disease with minimal success in preventing or reversing neuronal degeneration. In this review, we explore a relatively new field of research involving circular RNAs, whose potential roles as biomarkers and mediators of retinal disease pathogenesis have only just emerged. While knowledge of circular RNAs function is limited given its novelty, current evidence has highlighted their roles as modulators of microRNAs, regulators of gene transcription, and biomarkers of disease development and progression. Here, we summarize how circular RNAs may be implicated in the pathogenesis of common retinal diseases including diabetic retinopathy, glaucoma, proliferative vitreoretinopathy, and age-related macular degeneration. Further, we explore the potential of circular RNAs as novel biomarkers and therapeutic targets for the diagnosis and treatment of retinal diseases. |
| first_indexed | 2024-12-12T02:22:29Z |
| format | Article |
| id | doaj.art-53a4fc89cc41460eb5c4c880a76b07ab |
| institution | Directory Open Access Journal |
| issn | 1673-5374 |
| language | English |
| last_indexed | 2024-12-12T02:22:29Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neural Regeneration Research |
| spelling | doaj.art-53a4fc89cc41460eb5c4c880a76b07ab2022-12-22T00:41:38ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742022-01-011791875188010.4103/1673-5374.335691Emerging roles of circular RNAs in retinal diseasesAneliya HaninevaKaren Sophia ParkJoshua J WangMargaret M DeAngelisMichael H FarkasSarah X ZhangRetinal disorders are a group of ocular diseases whose onset is associated with a number of aberrant molecular and cellular processes or physical damages that affect retinal structure and function resulting in neural and vascular degeneration in the retina. Current research has primarily focused on delaying retinal disease with minimal success in preventing or reversing neuronal degeneration. In this review, we explore a relatively new field of research involving circular RNAs, whose potential roles as biomarkers and mediators of retinal disease pathogenesis have only just emerged. While knowledge of circular RNAs function is limited given its novelty, current evidence has highlighted their roles as modulators of microRNAs, regulators of gene transcription, and biomarkers of disease development and progression. Here, we summarize how circular RNAs may be implicated in the pathogenesis of common retinal diseases including diabetic retinopathy, glaucoma, proliferative vitreoretinopathy, and age-related macular degeneration. Further, we explore the potential of circular RNAs as novel biomarkers and therapeutic targets for the diagnosis and treatment of retinal diseases.http://www.nrronline.org/article.asp?issn=1673-5374;year=2022;volume=17;issue=9;spage=1875;epage=1880;aulast=Haninevaage-related macular degeneration; circular rna; diabetic retinopathy; glaucoma; microrna; proliferative vitreoretinopathy; retina |
| spellingShingle | Aneliya Hanineva Karen Sophia Park Joshua J Wang Margaret M DeAngelis Michael H Farkas Sarah X Zhang Emerging roles of circular RNAs in retinal diseases Neural Regeneration Research age-related macular degeneration; circular rna; diabetic retinopathy; glaucoma; microrna; proliferative vitreoretinopathy; retina |
| title | Emerging roles of circular RNAs in retinal diseases |
| title_full | Emerging roles of circular RNAs in retinal diseases |
| title_fullStr | Emerging roles of circular RNAs in retinal diseases |
| title_full_unstemmed | Emerging roles of circular RNAs in retinal diseases |
| title_short | Emerging roles of circular RNAs in retinal diseases |
| title_sort | emerging roles of circular rnas in retinal diseases |
| topic | age-related macular degeneration; circular rna; diabetic retinopathy; glaucoma; microrna; proliferative vitreoretinopathy; retina |
| url | http://www.nrronline.org/article.asp?issn=1673-5374;year=2022;volume=17;issue=9;spage=1875;epage=1880;aulast=Hanineva |
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