Extracellular Vesicles Derived from Gastrointestinal Microbiota: A New Approach to Clinical Studies
Extracellular vesicles, naturally released from all cell types including bacteria, are of great importance in medical microbiology due to transporting a variety of biomaterials, enzymes, and virulence factors, regulating immunity, and having roles in colonization and initiation of signaling pathways...
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| Format: | Article |
| Language: | English |
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Mazandaran University of Medical Sciences
2021-01-01
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| Series: | Journal of Mazandaran University of Medical Sciences |
| Subjects: | |
| Online Access: | http://jmums.mazums.ac.ir/article-1-16017-en.html |
| _version_ | 1797958872269324288 |
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| author | Zahra Hoseini Tavassol Fatemeh Ettehad Marvasti Shirin Hasani-Ranjbar Hanieh-Sadat Ejtahed Seyed Davar Siadat Bagher Larijani |
| author_facet | Zahra Hoseini Tavassol Fatemeh Ettehad Marvasti Shirin Hasani-Ranjbar Hanieh-Sadat Ejtahed Seyed Davar Siadat Bagher Larijani |
| author_sort | Zahra Hoseini Tavassol |
| collection | DOAJ |
| description | Extracellular vesicles, naturally released from all cell types including bacteria, are of great importance in medical microbiology due to transporting a variety of biomaterials, enzymes, and virulence factors, regulating immunity, and having roles in colonization and initiation of signaling pathways. These vesicles are also secreted from microbiota in the gastrointestinal tract and affect the host through various mechanisms by causing many systematic, metabolic, and physiological changes. Nowadays, the role of these vesicles is proven in maintaining gastrointestinal homeostasis, the pathogenesis, and diagnosis of related diseases such as obesity, diabetes, cancer, inflammatory bowel disease, mental disorders, and infectious diseases. Effective use of these characteristics could be possible by modulating the microbiota and its metabolites and using extracellular vesicles derived from probiotics. Therefore, the study of these vesicles as microbiota-derived products and next generation probiotics offers a new approach in clinical studies. The present study investigates how the microbiota-derived extracellular vesicles affect the host's health and play underlying roles in various diseases. |
| first_indexed | 2024-04-11T00:24:59Z |
| format | Article |
| id | doaj.art-53a547a9a09a4b52b6c45ce550dae844 |
| institution | Directory Open Access Journal |
| issn | 1735-9260 1735-9279 |
| language | English |
| last_indexed | 2024-04-11T00:24:59Z |
| publishDate | 2021-01-01 |
| publisher | Mazandaran University of Medical Sciences |
| record_format | Article |
| series | Journal of Mazandaran University of Medical Sciences |
| spelling | doaj.art-53a547a9a09a4b52b6c45ce550dae8442023-01-08T08:42:38ZengMazandaran University of Medical SciencesJournal of Mazandaran University of Medical Sciences1735-92601735-92792021-01-0130193152168Extracellular Vesicles Derived from Gastrointestinal Microbiota: A New Approach to Clinical StudiesZahra Hoseini Tavassol0Fatemeh Ettehad Marvasti1Shirin Hasani-Ranjbar2Hanieh-Sadat Ejtahed3Seyed Davar Siadat4Bagher Larijani5 PhD candidate in Medical Biotechnology, Obesity and Eating Habits Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran 2 Department of Mycobacteriology and Pulmonary Research, Microbiology Research Center (MRC), Pasteur Institute of Iran, Tehran, Iran MSc in Microbiology, Department of Mycobacteriology and Pulmonary Research, Microbiology Research Center (MRC), Pasteur Institute of Iran, Tehran, Iran Professor, Obesity and Eating Habits Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. Assistant Professor, Obesity and Eating Habits Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran and Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran Professor, Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.Department of Mycobacteriology and Pulmonary Research, Microbiology Research Center (MRC), Pasteur Institute of Iran, Tehran, Iran Professor, Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran Extracellular vesicles, naturally released from all cell types including bacteria, are of great importance in medical microbiology due to transporting a variety of biomaterials, enzymes, and virulence factors, regulating immunity, and having roles in colonization and initiation of signaling pathways. These vesicles are also secreted from microbiota in the gastrointestinal tract and affect the host through various mechanisms by causing many systematic, metabolic, and physiological changes. Nowadays, the role of these vesicles is proven in maintaining gastrointestinal homeostasis, the pathogenesis, and diagnosis of related diseases such as obesity, diabetes, cancer, inflammatory bowel disease, mental disorders, and infectious diseases. Effective use of these characteristics could be possible by modulating the microbiota and its metabolites and using extracellular vesicles derived from probiotics. Therefore, the study of these vesicles as microbiota-derived products and next generation probiotics offers a new approach in clinical studies. The present study investigates how the microbiota-derived extracellular vesicles affect the host's health and play underlying roles in various diseases.http://jmums.mazums.ac.ir/article-1-16017-en.htmlmicrobiotaextracellular vesiclesnext generation probiotics |
| spellingShingle | Zahra Hoseini Tavassol Fatemeh Ettehad Marvasti Shirin Hasani-Ranjbar Hanieh-Sadat Ejtahed Seyed Davar Siadat Bagher Larijani Extracellular Vesicles Derived from Gastrointestinal Microbiota: A New Approach to Clinical Studies Journal of Mazandaran University of Medical Sciences microbiota extracellular vesicles next generation probiotics |
| title | Extracellular Vesicles Derived from Gastrointestinal Microbiota: A New Approach to Clinical Studies |
| title_full | Extracellular Vesicles Derived from Gastrointestinal Microbiota: A New Approach to Clinical Studies |
| title_fullStr | Extracellular Vesicles Derived from Gastrointestinal Microbiota: A New Approach to Clinical Studies |
| title_full_unstemmed | Extracellular Vesicles Derived from Gastrointestinal Microbiota: A New Approach to Clinical Studies |
| title_short | Extracellular Vesicles Derived from Gastrointestinal Microbiota: A New Approach to Clinical Studies |
| title_sort | extracellular vesicles derived from gastrointestinal microbiota a new approach to clinical studies |
| topic | microbiota extracellular vesicles next generation probiotics |
| url | http://jmums.mazums.ac.ir/article-1-16017-en.html |
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