High Glucose-Mediated Tyrosine Nitration of PI3-Kinase: A Molecular Switch of Survival and Apoptosis in Endothelial Cells

High Glucose-Mediated Tyrosine Nitration of PI3-Kinase: A Molecular Switch of Survival and Apoptosis in Endothelial Cells

Diabetes and hyperglycemia are associated with increased retinal oxidative and nitrative stress and vascular cell death. Paradoxically, high glucose stimulates expression of survival and angiogenic growth factors. Therefore, we examined the hypothesis that high glucose-mediated tyrosine nitration ca...

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Bibliographic Details
Main Authors:	Sally L. Elshaer, Tahira Lemtalsi, Azza B. El-Remessy
Format:	Article
Language:	English
Published:	MDPI AG 2018-03-01
Series:	Antioxidants
Subjects:	peroxynitrite tyrosine nitration high glucose PI3-kinase apoptosis endothelial cells p38 MAPK survival Akt
Online Access:	http://www.mdpi.com/2076-3921/7/4/47

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