A Review on Mechanistic Insight of Plant Derived Anticancer Bioactive Phytocompounds and Their Structure Activity Relationship
Cancer is a disorder that rigorously affects the human population worldwide. There is a steady demand for new remedies to both treat and prevent this life-threatening sickness due to toxicities, drug resistance and therapeutic failures in current conventional therapies. Researchers around the world...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-05-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/27/9/3036 |
| _version_ | 1797503571486310400 |
|---|---|
| author | Kishor Mazumder Asma Aktar Priyanka Roy Biswajit Biswas Md. Emran Hossain Kishore Kumar Sarkar Sitesh Chandra Bachar Firoj Ahmed A. S. M. Monjur-Al-Hossain Koichi Fukase |
| author_facet | Kishor Mazumder Asma Aktar Priyanka Roy Biswajit Biswas Md. Emran Hossain Kishore Kumar Sarkar Sitesh Chandra Bachar Firoj Ahmed A. S. M. Monjur-Al-Hossain Koichi Fukase |
| author_sort | Kishor Mazumder |
| collection | DOAJ |
| description | Cancer is a disorder that rigorously affects the human population worldwide. There is a steady demand for new remedies to both treat and prevent this life-threatening sickness due to toxicities, drug resistance and therapeutic failures in current conventional therapies. Researchers around the world are drawing their attention towards compounds of natural origin. For decades, human beings have been using the flora of the world as a source of cancer chemotherapeutic agents. Currently, clinically approved anticancer compounds are vincristine, vinblastine, taxanes, and podophyllotoxin, all of which come from natural sources. With the triumph of these compounds that have been developed into staple drug products for most cancer therapies, new technologies are now appearing to search for novel biomolecules with anticancer activities. Ellipticine, camptothecin, combretastatin, curcumin, homoharringtonine and others are plant derived bioactive phytocompounds with potential anticancer properties. Researchers have improved the field further through the use of advanced analytical chemistry and computational tools of analysis. The investigation of new strategies for administration such as nanotechnology may enable the development of the phytocompounds as drug products. These technologies have enhanced the anticancer potential of plant-derived drugs with the aim of site-directed drug delivery, enhanced bioavailability, and reduced toxicity. This review discusses mechanistic insights into anticancer compounds of natural origins and their structural activity relationships that make them targets for anticancer treatments. |
| first_indexed | 2024-03-10T03:52:36Z |
| format | Article |
| id | doaj.art-53a6806dbcb54cb8bfb8ee772c4d615b |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T03:52:36Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-53a6806dbcb54cb8bfb8ee772c4d615b2023-11-23T08:53:17ZengMDPI AGMolecules1420-30492022-05-01279303610.3390/molecules27093036A Review on Mechanistic Insight of Plant Derived Anticancer Bioactive Phytocompounds and Their Structure Activity RelationshipKishor Mazumder0Asma Aktar1Priyanka Roy2Biswajit Biswas3Md. Emran Hossain4Kishore Kumar Sarkar5Sitesh Chandra Bachar6Firoj Ahmed7A. S. M. Monjur-Al-Hossain8Koichi Fukase9Department of Pharmacy, Jashore University of Science and Technology, Jashore 7408, BangladeshDepartment of Pharmacy, Jashore University of Science and Technology, Jashore 7408, BangladeshDepartment of Pharmacy, Jashore University of Science and Technology, Jashore 7408, BangladeshDepartment of Pharmacy, Jashore University of Science and Technology, Jashore 7408, BangladeshDepartment of Pharmacy, Jashore University of Science and Technology, Jashore 7408, BangladeshDepartment of Pharmacy, Jashore University of Science and Technology, Jashore 7408, BangladeshDepartment of Pharmacy, Faculty of Pharmacy, University of Dhaka, Dhaka 1207, BangladeshDepartment of Pharmacy, Faculty of Pharmacy, University of Dhaka, Dhaka 1207, BangladeshDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka, Dhaka 1207, BangladeshDepartment of Chemistry, Graduate School of Science, Osaka University, 1-1 Machikaneyama, Toyonaka, Osaka 560-0043, JapanCancer is a disorder that rigorously affects the human population worldwide. There is a steady demand for new remedies to both treat and prevent this life-threatening sickness due to toxicities, drug resistance and therapeutic failures in current conventional therapies. Researchers around the world are drawing their attention towards compounds of natural origin. For decades, human beings have been using the flora of the world as a source of cancer chemotherapeutic agents. Currently, clinically approved anticancer compounds are vincristine, vinblastine, taxanes, and podophyllotoxin, all of which come from natural sources. With the triumph of these compounds that have been developed into staple drug products for most cancer therapies, new technologies are now appearing to search for novel biomolecules with anticancer activities. Ellipticine, camptothecin, combretastatin, curcumin, homoharringtonine and others are plant derived bioactive phytocompounds with potential anticancer properties. Researchers have improved the field further through the use of advanced analytical chemistry and computational tools of analysis. The investigation of new strategies for administration such as nanotechnology may enable the development of the phytocompounds as drug products. These technologies have enhanced the anticancer potential of plant-derived drugs with the aim of site-directed drug delivery, enhanced bioavailability, and reduced toxicity. This review discusses mechanistic insights into anticancer compounds of natural origins and their structural activity relationships that make them targets for anticancer treatments.https://www.mdpi.com/1420-3049/27/9/3036neoplastic diseaseproliferationanticancer bioactive phytocompoundsstructure activity relationship (SAR)cytotoxic agents |
| spellingShingle | Kishor Mazumder Asma Aktar Priyanka Roy Biswajit Biswas Md. Emran Hossain Kishore Kumar Sarkar Sitesh Chandra Bachar Firoj Ahmed A. S. M. Monjur-Al-Hossain Koichi Fukase A Review on Mechanistic Insight of Plant Derived Anticancer Bioactive Phytocompounds and Their Structure Activity Relationship Molecules neoplastic disease proliferation anticancer bioactive phytocompounds structure activity relationship (SAR) cytotoxic agents |
| title | A Review on Mechanistic Insight of Plant Derived Anticancer Bioactive Phytocompounds and Their Structure Activity Relationship |
| title_full | A Review on Mechanistic Insight of Plant Derived Anticancer Bioactive Phytocompounds and Their Structure Activity Relationship |
| title_fullStr | A Review on Mechanistic Insight of Plant Derived Anticancer Bioactive Phytocompounds and Their Structure Activity Relationship |
| title_full_unstemmed | A Review on Mechanistic Insight of Plant Derived Anticancer Bioactive Phytocompounds and Their Structure Activity Relationship |
| title_short | A Review on Mechanistic Insight of Plant Derived Anticancer Bioactive Phytocompounds and Their Structure Activity Relationship |
| title_sort | review on mechanistic insight of plant derived anticancer bioactive phytocompounds and their structure activity relationship |
| topic | neoplastic disease proliferation anticancer bioactive phytocompounds structure activity relationship (SAR) cytotoxic agents |
| url | https://www.mdpi.com/1420-3049/27/9/3036 |
| work_keys_str_mv | AT kishormazumder areviewonmechanisticinsightofplantderivedanticancerbioactivephytocompoundsandtheirstructureactivityrelationship AT asmaaktar areviewonmechanisticinsightofplantderivedanticancerbioactivephytocompoundsandtheirstructureactivityrelationship AT priyankaroy areviewonmechanisticinsightofplantderivedanticancerbioactivephytocompoundsandtheirstructureactivityrelationship AT biswajitbiswas areviewonmechanisticinsightofplantderivedanticancerbioactivephytocompoundsandtheirstructureactivityrelationship AT mdemranhossain areviewonmechanisticinsightofplantderivedanticancerbioactivephytocompoundsandtheirstructureactivityrelationship AT kishorekumarsarkar areviewonmechanisticinsightofplantderivedanticancerbioactivephytocompoundsandtheirstructureactivityrelationship AT siteshchandrabachar areviewonmechanisticinsightofplantderivedanticancerbioactivephytocompoundsandtheirstructureactivityrelationship AT firojahmed areviewonmechanisticinsightofplantderivedanticancerbioactivephytocompoundsandtheirstructureactivityrelationship AT asmmonjuralhossain areviewonmechanisticinsightofplantderivedanticancerbioactivephytocompoundsandtheirstructureactivityrelationship AT koichifukase areviewonmechanisticinsightofplantderivedanticancerbioactivephytocompoundsandtheirstructureactivityrelationship AT kishormazumder reviewonmechanisticinsightofplantderivedanticancerbioactivephytocompoundsandtheirstructureactivityrelationship AT asmaaktar reviewonmechanisticinsightofplantderivedanticancerbioactivephytocompoundsandtheirstructureactivityrelationship AT priyankaroy reviewonmechanisticinsightofplantderivedanticancerbioactivephytocompoundsandtheirstructureactivityrelationship AT biswajitbiswas reviewonmechanisticinsightofplantderivedanticancerbioactivephytocompoundsandtheirstructureactivityrelationship AT mdemranhossain reviewonmechanisticinsightofplantderivedanticancerbioactivephytocompoundsandtheirstructureactivityrelationship AT kishorekumarsarkar reviewonmechanisticinsightofplantderivedanticancerbioactivephytocompoundsandtheirstructureactivityrelationship AT siteshchandrabachar reviewonmechanisticinsightofplantderivedanticancerbioactivephytocompoundsandtheirstructureactivityrelationship AT firojahmed reviewonmechanisticinsightofplantderivedanticancerbioactivephytocompoundsandtheirstructureactivityrelationship AT asmmonjuralhossain reviewonmechanisticinsightofplantderivedanticancerbioactivephytocompoundsandtheirstructureactivityrelationship AT koichifukase reviewonmechanisticinsightofplantderivedanticancerbioactivephytocompoundsandtheirstructureactivityrelationship |