Antidepressant effect and neural mechanism of Acer tegmentosum in repeated stress–induced ovariectomized female rats
Acer tegmentosum (ATM) has antioxidant and anti-adipogenic activity. However, few studies have investigated the pharmacological activity or mechanism of ATM as an antidepressant agent. We assessed the antidepressant effect of ATM in modulating menopausal depressive symptoms and its mechanisms in ova...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2020-08-01
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| Series: | Animal Cells and Systems |
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| Online Access: | http://dx.doi.org/10.1080/19768354.2020.1808063 |
| _version_ | 1818292039364640768 |
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| author | Hyun-Jung Park Hyun Soo Shim SongYi Park Insop Shim |
| author_facet | Hyun-Jung Park Hyun Soo Shim SongYi Park Insop Shim |
| author_sort | Hyun-Jung Park |
| collection | DOAJ |
| description | Acer tegmentosum (ATM) has antioxidant and anti-adipogenic activity. However, few studies have investigated the pharmacological activity or mechanism of ATM as an antidepressant agent. We assessed the antidepressant effect of ATM in modulating menopausal depressive symptoms and its mechanisms in ovariectomized (OVX) and repeatedly stressed (RS) female rats. The female rats were randomly divided into four groups: (1) naïve normal (normal) group, (2) OVX + repeated stress + saline-treated (control) group, (3) OVX + repeated stress + ATM (100 mg•kg−1)-treated (ATM100) group and (4) OVX + repeated stress + ATM (400 mg•kg−1)-treated (ATM400) group. We performed a battery of tests, such as the forced swimming test (FST), the sucrose intake test, and social exploration. After behavior testing, serum corticosterone levels were examined, followed by immunohistochemical determination of c-Fos, tyrosine hydroxylase (TH), and interleukin-1 beta (IL-1β) expression in the brain. ATM administration was associated with significantly decreased immobility time in the FST. Also, the control group tended to have decreased sucrose intake and social exploration compared with the normal group. However, ATM treatment was associated with markedly increased sucrose intake and active social exploration. In the paraventricular nucleus, c-Fos and IL-1β expression were significantly decreased in the ATM400 group compared with the control group. Compared with the control group, high-dose ATM administration was also associated with markedly decreased expression of TH-immunoreactive neurons in the locus coeruleus. The study findings demonstrated that ATM treatment effectively decreased behavioral and pathophysiological depression-like responses. |
| first_indexed | 2024-12-13T02:53:37Z |
| format | Article |
| id | doaj.art-53a75717e6df4818b26298b26d9f0062 |
| institution | Directory Open Access Journal |
| issn | 1976-8354 2151-2485 |
| language | English |
| last_indexed | 2024-12-13T02:53:37Z |
| publishDate | 2020-08-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Animal Cells and Systems |
| spelling | doaj.art-53a75717e6df4818b26298b26d9f00622022-12-22T00:02:00ZengTaylor & Francis GroupAnimal Cells and Systems1976-83542151-24852020-08-01001910.1080/19768354.2020.18080631808063Antidepressant effect and neural mechanism of Acer tegmentosum in repeated stress–induced ovariectomized female ratsHyun-Jung Park0Hyun Soo Shim1SongYi Park2Insop Shim3Department of Physiology, College of Medicine, Kyung Hee UniversityDepartment of Physiology, College of Medicine, Kyung Hee UniversityDepartment of Physiology, College of Medicine, Kyung Hee UniversityDepartment of Physiology, College of Medicine, Kyung Hee UniversityAcer tegmentosum (ATM) has antioxidant and anti-adipogenic activity. However, few studies have investigated the pharmacological activity or mechanism of ATM as an antidepressant agent. We assessed the antidepressant effect of ATM in modulating menopausal depressive symptoms and its mechanisms in ovariectomized (OVX) and repeatedly stressed (RS) female rats. The female rats were randomly divided into four groups: (1) naïve normal (normal) group, (2) OVX + repeated stress + saline-treated (control) group, (3) OVX + repeated stress + ATM (100 mg•kg−1)-treated (ATM100) group and (4) OVX + repeated stress + ATM (400 mg•kg−1)-treated (ATM400) group. We performed a battery of tests, such as the forced swimming test (FST), the sucrose intake test, and social exploration. After behavior testing, serum corticosterone levels were examined, followed by immunohistochemical determination of c-Fos, tyrosine hydroxylase (TH), and interleukin-1 beta (IL-1β) expression in the brain. ATM administration was associated with significantly decreased immobility time in the FST. Also, the control group tended to have decreased sucrose intake and social exploration compared with the normal group. However, ATM treatment was associated with markedly increased sucrose intake and active social exploration. In the paraventricular nucleus, c-Fos and IL-1β expression were significantly decreased in the ATM400 group compared with the control group. Compared with the control group, high-dose ATM administration was also associated with markedly decreased expression of TH-immunoreactive neurons in the locus coeruleus. The study findings demonstrated that ATM treatment effectively decreased behavioral and pathophysiological depression-like responses.http://dx.doi.org/10.1080/19768354.2020.1808063acer tegmentosumrepeated stresscytokineovariectomytyrosine hydroxylase (th) |
| spellingShingle | Hyun-Jung Park Hyun Soo Shim SongYi Park Insop Shim Antidepressant effect and neural mechanism of Acer tegmentosum in repeated stress–induced ovariectomized female rats Animal Cells and Systems acer tegmentosum repeated stress cytokine ovariectomy tyrosine hydroxylase (th) |
| title | Antidepressant effect and neural mechanism of Acer tegmentosum in repeated stress–induced ovariectomized female rats |
| title_full | Antidepressant effect and neural mechanism of Acer tegmentosum in repeated stress–induced ovariectomized female rats |
| title_fullStr | Antidepressant effect and neural mechanism of Acer tegmentosum in repeated stress–induced ovariectomized female rats |
| title_full_unstemmed | Antidepressant effect and neural mechanism of Acer tegmentosum in repeated stress–induced ovariectomized female rats |
| title_short | Antidepressant effect and neural mechanism of Acer tegmentosum in repeated stress–induced ovariectomized female rats |
| title_sort | antidepressant effect and neural mechanism of acer tegmentosum in repeated stress induced ovariectomized female rats |
| topic | acer tegmentosum repeated stress cytokine ovariectomy tyrosine hydroxylase (th) |
| url | http://dx.doi.org/10.1080/19768354.2020.1808063 |
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