Successful long-term terbinafine therapy in an asthmatic patient with Aspergillus sensitization and bronchiectasis
Severe asthma with fungal sensitization (SAFS) is estimated to affect ~25% of patients with poorly controlled asthma. Tri-azole therapy is effective in only 60–80% and side effects are common. We report a 25 years-old woman with severe asthma, Aspergillus sensitization and marked bronchiectasis that...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2017-06-01
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| Series: | Medical Mycology Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211753917300155 |
| _version_ | 1818506795544477696 |
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| author | Isabel Rodriguez-Goncer Rob Niven David W. Denning |
| author_facet | Isabel Rodriguez-Goncer Rob Niven David W. Denning |
| author_sort | Isabel Rodriguez-Goncer |
| collection | DOAJ |
| description | Severe asthma with fungal sensitization (SAFS) is estimated to affect ~25% of patients with poorly controlled asthma. Tri-azole therapy is effective in only 60–80% and side effects are common. We report a 25 years-old woman with severe asthma, Aspergillus sensitization and marked bronchiectasis that developed a rare Achilles-tendinopathy with both itraconazole and voriconazole. She started a trial with terbinafine as salvage therapy that led to a striking improvement and long-term control of her respiratory disease. |
| first_indexed | 2024-12-10T22:09:28Z |
| format | Article |
| id | doaj.art-53a91493759344f7b54b7f584521b28c |
| institution | Directory Open Access Journal |
| issn | 2211-7539 |
| language | English |
| last_indexed | 2024-12-10T22:09:28Z |
| publishDate | 2017-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Medical Mycology Case Reports |
| spelling | doaj.art-53a91493759344f7b54b7f584521b28c2022-12-22T01:31:38ZengElsevierMedical Mycology Case Reports2211-75392017-06-0116C313310.1016/j.mmcr.2017.04.005Successful long-term terbinafine therapy in an asthmatic patient with Aspergillus sensitization and bronchiectasisIsabel Rodriguez-Goncer0Rob Niven1David W. Denning2National Aspergillosis Centre, University Hospital of South Manchester, M23 9LT Manchester, UKSevere Asthma Service, Department of Respiratory Medicine, University Hospital of South Manchester, M23 9LT Manchester, UKNational Aspergillosis Centre, University Hospital of South Manchester, M23 9LT Manchester, UKSevere asthma with fungal sensitization (SAFS) is estimated to affect ~25% of patients with poorly controlled asthma. Tri-azole therapy is effective in only 60–80% and side effects are common. We report a 25 years-old woman with severe asthma, Aspergillus sensitization and marked bronchiectasis that developed a rare Achilles-tendinopathy with both itraconazole and voriconazole. She started a trial with terbinafine as salvage therapy that led to a striking improvement and long-term control of her respiratory disease.http://www.sciencedirect.com/science/article/pii/S2211753917300155Aspergillus sppAsthmaTerbinafineTendinopathyBronchiectasis |
| spellingShingle | Isabel Rodriguez-Goncer Rob Niven David W. Denning Successful long-term terbinafine therapy in an asthmatic patient with Aspergillus sensitization and bronchiectasis Medical Mycology Case Reports Aspergillus spp Asthma Terbinafine Tendinopathy Bronchiectasis |
| title | Successful long-term terbinafine therapy in an asthmatic patient with Aspergillus sensitization and bronchiectasis |
| title_full | Successful long-term terbinafine therapy in an asthmatic patient with Aspergillus sensitization and bronchiectasis |
| title_fullStr | Successful long-term terbinafine therapy in an asthmatic patient with Aspergillus sensitization and bronchiectasis |
| title_full_unstemmed | Successful long-term terbinafine therapy in an asthmatic patient with Aspergillus sensitization and bronchiectasis |
| title_short | Successful long-term terbinafine therapy in an asthmatic patient with Aspergillus sensitization and bronchiectasis |
| title_sort | successful long term terbinafine therapy in an asthmatic patient with aspergillus sensitization and bronchiectasis |
| topic | Aspergillus spp Asthma Terbinafine Tendinopathy Bronchiectasis |
| url | http://www.sciencedirect.com/science/article/pii/S2211753917300155 |
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