Long-term ambient air pollution exposure and cardio-respiratory disease in China: findings from a prospective cohort study
Abstract Background Existing evidence on long-term ambient air pollution (AAP) exposure and risk of cardio-respiratory diseases in China is mainly on mortality, and based on area average concentrations from fixed-site monitors for individual exposures. Substantial uncertainty persists, therefore, ab...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-03-01
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| Series: | Environmental Health |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12940-023-00978-9 |
| _version_ | 1797853579860508672 |
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| author | Neil Wright Katherine Newell Ka Hung Chan Simon Gilbert Alex Hacker Yan Lu Yu Guo Pei Pei Canqing Yu Jun Lv Junshi Chen Liming Li Om Kurmi Zhengming Chen Kin Bong Hubert Lam Christiana Kartsonaki |
| author_facet | Neil Wright Katherine Newell Ka Hung Chan Simon Gilbert Alex Hacker Yan Lu Yu Guo Pei Pei Canqing Yu Jun Lv Junshi Chen Liming Li Om Kurmi Zhengming Chen Kin Bong Hubert Lam Christiana Kartsonaki |
| author_sort | Neil Wright |
| collection | DOAJ |
| description | Abstract Background Existing evidence on long-term ambient air pollution (AAP) exposure and risk of cardio-respiratory diseases in China is mainly on mortality, and based on area average concentrations from fixed-site monitors for individual exposures. Substantial uncertainty persists, therefore, about the shape and strength of the relationship when assessed using more personalised individual exposure data. We aimed to examine the relationships between AAP exposure and risk of cardio-respiratory diseases using predicted local levels of AAP. Methods A prospective study included 50,407 participants aged 30–79 years from Suzhou, China, with concentrations of nitrogen dioxide (NO2), sulphur dioxide (SO2), fine (PM2.5), and inhalable (PM10) particulate matter, ozone (O3) and carbon monoxide (CO) and incident cases of cardiovascular disease (CVD) (n = 2,563) and respiratory disease (n = 1,764) recorded during 2013–2015. Cox regression models with time-dependent covariates were used to estimate adjusted hazard ratios (HRs) for diseases associated with local-level concentrations of AAP exposure, estimated using Bayesian spatio–temporal modelling. Results The study period of 2013–2015 included a total of 135,199 person-years of follow-up for CVD. There was a positive association of AAP, particularly SO2 and O3, with risk of major cardiovascular and respiratory diseases. Each 10 µg/m3 increase in SO2 was associated with adjusted hazard ratios (HRs) of 1.07 (95% CI: 1.02, 1.12) for CVD, 1.25 (1.08, 1.44) for COPD and 1.12 (1.02, 1.23) for pneumonia. Similarly, each 10 µg/m3 increase in O3 was associated with adjusted HR of 1.02 (1.01, 1.03) for CVD, 1.03 (1.02, 1.05) for all stroke, and 1.04 (1.02, 1.06) for pneumonia. Conclusions Among adults in urban China, long-term exposure to ambient air pollution is associated with a higher risk of cardio-respiratory disease. |
| first_indexed | 2024-04-09T19:52:57Z |
| format | Article |
| id | doaj.art-53aba0e61e7d4696bc24ec756a86f48d |
| institution | Directory Open Access Journal |
| issn | 1476-069X |
| language | English |
| last_indexed | 2024-04-09T19:52:57Z |
| publishDate | 2023-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Environmental Health |
| spelling | doaj.art-53aba0e61e7d4696bc24ec756a86f48d2023-04-03T05:39:31ZengBMCEnvironmental Health1476-069X2023-03-0122111110.1186/s12940-023-00978-9Long-term ambient air pollution exposure and cardio-respiratory disease in China: findings from a prospective cohort studyNeil Wright0Katherine Newell1Ka Hung Chan2Simon Gilbert3Alex Hacker4Yan Lu5Yu Guo6Pei Pei7Canqing Yu8Jun Lv9Junshi Chen10Liming Li11Om Kurmi12Zhengming Chen13Kin Bong Hubert Lam14Christiana Kartsonaki15Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Big Data Institute BuildingClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Big Data Institute BuildingClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Big Data Institute BuildingClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Big Data Institute BuildingClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Big Data Institute BuildingNCDs Prevention and Control Department, Suzhou CDCChinese Academy of Medical SciencesPeking University Center for Public Health and Epidemic Preparedness and Response, Peking UniversityPeking University Center for Public Health and Epidemic Preparedness and Response, Peking UniversityPeking University Center for Public Health and Epidemic Preparedness and Response, Peking UniversityNational Center for Food Safety Risk AssessmentPeking University Center for Public Health and Epidemic Preparedness and Response, Peking UniversityResearch Centre for Intelligent Healthcare, Coventry UniversityClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Big Data Institute BuildingClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Big Data Institute BuildingClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Big Data Institute BuildingAbstract Background Existing evidence on long-term ambient air pollution (AAP) exposure and risk of cardio-respiratory diseases in China is mainly on mortality, and based on area average concentrations from fixed-site monitors for individual exposures. Substantial uncertainty persists, therefore, about the shape and strength of the relationship when assessed using more personalised individual exposure data. We aimed to examine the relationships between AAP exposure and risk of cardio-respiratory diseases using predicted local levels of AAP. Methods A prospective study included 50,407 participants aged 30–79 years from Suzhou, China, with concentrations of nitrogen dioxide (NO2), sulphur dioxide (SO2), fine (PM2.5), and inhalable (PM10) particulate matter, ozone (O3) and carbon monoxide (CO) and incident cases of cardiovascular disease (CVD) (n = 2,563) and respiratory disease (n = 1,764) recorded during 2013–2015. Cox regression models with time-dependent covariates were used to estimate adjusted hazard ratios (HRs) for diseases associated with local-level concentrations of AAP exposure, estimated using Bayesian spatio–temporal modelling. Results The study period of 2013–2015 included a total of 135,199 person-years of follow-up for CVD. There was a positive association of AAP, particularly SO2 and O3, with risk of major cardiovascular and respiratory diseases. Each 10 µg/m3 increase in SO2 was associated with adjusted hazard ratios (HRs) of 1.07 (95% CI: 1.02, 1.12) for CVD, 1.25 (1.08, 1.44) for COPD and 1.12 (1.02, 1.23) for pneumonia. Similarly, each 10 µg/m3 increase in O3 was associated with adjusted HR of 1.02 (1.01, 1.03) for CVD, 1.03 (1.02, 1.05) for all stroke, and 1.04 (1.02, 1.06) for pneumonia. Conclusions Among adults in urban China, long-term exposure to ambient air pollution is associated with a higher risk of cardio-respiratory disease.https://doi.org/10.1186/s12940-023-00978-9Air pollutionCardiovascular diseaseRespiratory disease |
| spellingShingle | Neil Wright Katherine Newell Ka Hung Chan Simon Gilbert Alex Hacker Yan Lu Yu Guo Pei Pei Canqing Yu Jun Lv Junshi Chen Liming Li Om Kurmi Zhengming Chen Kin Bong Hubert Lam Christiana Kartsonaki Long-term ambient air pollution exposure and cardio-respiratory disease in China: findings from a prospective cohort study Environmental Health Air pollution Cardiovascular disease Respiratory disease |
| title | Long-term ambient air pollution exposure and cardio-respiratory disease in China: findings from a prospective cohort study |
| title_full | Long-term ambient air pollution exposure and cardio-respiratory disease in China: findings from a prospective cohort study |
| title_fullStr | Long-term ambient air pollution exposure and cardio-respiratory disease in China: findings from a prospective cohort study |
| title_full_unstemmed | Long-term ambient air pollution exposure and cardio-respiratory disease in China: findings from a prospective cohort study |
| title_short | Long-term ambient air pollution exposure and cardio-respiratory disease in China: findings from a prospective cohort study |
| title_sort | long term ambient air pollution exposure and cardio respiratory disease in china findings from a prospective cohort study |
| topic | Air pollution Cardiovascular disease Respiratory disease |
| url | https://doi.org/10.1186/s12940-023-00978-9 |
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