Different cardiovascular responses to exercise training in hypertensive women receiving β-blockers or angiotensin receptor blockers: A pilot study
Aim To verify the influence of β-blockers or angiotensin receptor blockers on cardiovascular responses to exercise training in hypertensive post-menopausal women. Methods Postmenopausal women were allocated into: healthy control group (CON; n = 9); angiotensin receptor blockers users (ARB; n = 19);...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2022-07-01
|
| Series: | Clinical and Experimental Hypertension |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/10641963.2022.2065290 |
| _version_ | 1797681094713147392 |
|---|---|
| author | Igor M. Mariano Ana Luiza Amaral Victor Hugo V. Carrijo Juliene G. Costa Mateus de L. Rodrigues Thulio M. Cunha Guilherme M. Puga |
| author_facet | Igor M. Mariano Ana Luiza Amaral Victor Hugo V. Carrijo Juliene G. Costa Mateus de L. Rodrigues Thulio M. Cunha Guilherme M. Puga |
| author_sort | Igor M. Mariano |
| collection | DOAJ |
| description | Aim To verify the influence of β-blockers or angiotensin receptor blockers on cardiovascular responses to exercise training in hypertensive post-menopausal women. Methods Postmenopausal women were allocated into: healthy control group (CON; n = 9); angiotensin receptor blockers users (ARB; n = 19); and β-adrenergic blockers users (BB; n = 19). Before and after 12 weeks of combined (aerobic and resistance) exercise training they were evaluated by: heart rate (HR) and its variability (HRV), blood pressure (BP) under stress (Cold pressor and Stroop color tests), and ambulatorial BP and its variability. Results In ambulatorial BP analysis only in ARB group awake systolic BP decreased (p = .011; ARB: From 122 ± 11 to 117 ± 9; BB: From 118 ± 7 to 114 ± 5; CON: From 121 ± 7 to 127 ± 11 mmHg). There were time effects in BP reactivity to stress, where BP reactivity after Stroop color and Cold pressor test decreased in all groups. In BP variability analysis, only BB group has significative decreased values in systolic SD24 (p = .007; ΔARB = −0.3 ± 2.0; ΔBB = −1.3 ± 2.0; ΔCON = 0.8 ± 1.7 mmHg) and SDdn (p = .006; ΔARB = −0.2 ± 1.6; ΔBB = −1.3 ± 2.0; ΔCON = 0.4 ± 2.1 mmHg). HRV analysis demonstrated that post-training, only in BB group LF/HF decreased (p = .001; ΔARB = 0.1 ± 0.8; ΔBB = −0.4 ± 1.5; ΔCON = 1.0 ± 1.7). Conclusion ARB present pronounced responses in awake ambulatorial systolic BP, while β-blockers users present greater responses in BP variability. Besides that, exercise can mitigate BP reactivity to stress with no differences between groups. Lastly, there were no major differences in HRV. Trial registry at “Clinicaltrials.gov” NCT03529838 |
| first_indexed | 2024-03-11T23:39:53Z |
| format | Article |
| id | doaj.art-53aedafba12041b5a8302314a178a6c1 |
| institution | Directory Open Access Journal |
| issn | 1064-1963 1525-6006 |
| language | English |
| last_indexed | 2024-03-11T23:39:53Z |
| publishDate | 2022-07-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Clinical and Experimental Hypertension |
| spelling | doaj.art-53aedafba12041b5a8302314a178a6c12023-09-19T16:04:07ZengTaylor & Francis GroupClinical and Experimental Hypertension1064-19631525-60062022-07-0144544245010.1080/10641963.2022.20652902065290Different cardiovascular responses to exercise training in hypertensive women receiving β-blockers or angiotensin receptor blockers: A pilot studyIgor M. Mariano0Ana Luiza Amaral1Victor Hugo V. Carrijo2Juliene G. Costa3Mateus de L. Rodrigues4Thulio M. Cunha5Guilherme M. Puga6Federal University of UberlândiaFederal University of UberlândiaFederal University of UberlândiaFederal University of UberlândiaFederal University of UberlândiaFederal University of UberlândiaFederal University of UberlândiaAim To verify the influence of β-blockers or angiotensin receptor blockers on cardiovascular responses to exercise training in hypertensive post-menopausal women. Methods Postmenopausal women were allocated into: healthy control group (CON; n = 9); angiotensin receptor blockers users (ARB; n = 19); and β-adrenergic blockers users (BB; n = 19). Before and after 12 weeks of combined (aerobic and resistance) exercise training they were evaluated by: heart rate (HR) and its variability (HRV), blood pressure (BP) under stress (Cold pressor and Stroop color tests), and ambulatorial BP and its variability. Results In ambulatorial BP analysis only in ARB group awake systolic BP decreased (p = .011; ARB: From 122 ± 11 to 117 ± 9; BB: From 118 ± 7 to 114 ± 5; CON: From 121 ± 7 to 127 ± 11 mmHg). There were time effects in BP reactivity to stress, where BP reactivity after Stroop color and Cold pressor test decreased in all groups. In BP variability analysis, only BB group has significative decreased values in systolic SD24 (p = .007; ΔARB = −0.3 ± 2.0; ΔBB = −1.3 ± 2.0; ΔCON = 0.8 ± 1.7 mmHg) and SDdn (p = .006; ΔARB = −0.2 ± 1.6; ΔBB = −1.3 ± 2.0; ΔCON = 0.4 ± 2.1 mmHg). HRV analysis demonstrated that post-training, only in BB group LF/HF decreased (p = .001; ΔARB = 0.1 ± 0.8; ΔBB = −0.4 ± 1.5; ΔCON = 1.0 ± 1.7). Conclusion ARB present pronounced responses in awake ambulatorial systolic BP, while β-blockers users present greater responses in BP variability. Besides that, exercise can mitigate BP reactivity to stress with no differences between groups. Lastly, there were no major differences in HRV. Trial registry at “Clinicaltrials.gov” NCT03529838http://dx.doi.org/10.1080/10641963.2022.2065290aerobic exerciseresistance exerciseblood pressurehypertensionblood pressure variabilityheart rate variability |
| spellingShingle | Igor M. Mariano Ana Luiza Amaral Victor Hugo V. Carrijo Juliene G. Costa Mateus de L. Rodrigues Thulio M. Cunha Guilherme M. Puga Different cardiovascular responses to exercise training in hypertensive women receiving β-blockers or angiotensin receptor blockers: A pilot study Clinical and Experimental Hypertension aerobic exercise resistance exercise blood pressure hypertension blood pressure variability heart rate variability |
| title | Different cardiovascular responses to exercise training in hypertensive women receiving β-blockers or angiotensin receptor blockers: A pilot study |
| title_full | Different cardiovascular responses to exercise training in hypertensive women receiving β-blockers or angiotensin receptor blockers: A pilot study |
| title_fullStr | Different cardiovascular responses to exercise training in hypertensive women receiving β-blockers or angiotensin receptor blockers: A pilot study |
| title_full_unstemmed | Different cardiovascular responses to exercise training in hypertensive women receiving β-blockers or angiotensin receptor blockers: A pilot study |
| title_short | Different cardiovascular responses to exercise training in hypertensive women receiving β-blockers or angiotensin receptor blockers: A pilot study |
| title_sort | different cardiovascular responses to exercise training in hypertensive women receiving β blockers or angiotensin receptor blockers a pilot study |
| topic | aerobic exercise resistance exercise blood pressure hypertension blood pressure variability heart rate variability |
| url | http://dx.doi.org/10.1080/10641963.2022.2065290 |
| work_keys_str_mv | AT igormmariano differentcardiovascularresponsestoexercisetraininginhypertensivewomenreceivingbblockersorangiotensinreceptorblockersapilotstudy AT analuizaamaral differentcardiovascularresponsestoexercisetraininginhypertensivewomenreceivingbblockersorangiotensinreceptorblockersapilotstudy AT victorhugovcarrijo differentcardiovascularresponsestoexercisetraininginhypertensivewomenreceivingbblockersorangiotensinreceptorblockersapilotstudy AT julienegcosta differentcardiovascularresponsestoexercisetraininginhypertensivewomenreceivingbblockersorangiotensinreceptorblockersapilotstudy AT mateusdelrodrigues differentcardiovascularresponsestoexercisetraininginhypertensivewomenreceivingbblockersorangiotensinreceptorblockersapilotstudy AT thuliomcunha differentcardiovascularresponsestoexercisetraininginhypertensivewomenreceivingbblockersorangiotensinreceptorblockersapilotstudy AT guilhermempuga differentcardiovascularresponsestoexercisetraininginhypertensivewomenreceivingbblockersorangiotensinreceptorblockersapilotstudy |