Complete nutrition drink with retrograded starch is low glycemic, and the individual glucose response to the low glycemic complete nutrition drink depends on fasting insulin levels and HOMA-IR in a randomized cross-over control trial
Complete nutrition drinks with a low glycemic index (GI) provide nutritional support and prevent hyperglycaemia. The present study identified GI and factors predicting individual glucose response to a new complete nutrition drink. A randomised cross-over controlled trial was conducted in eighteen he...
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2022-01-01
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| Series: | Journal of Nutritional Science |
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| Online Access: | https://www.cambridge.org/core/product/identifier/S2048679022000234/type/journal_article |
| _version_ | 1811155915702796288 |
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| author | Warisara Wongniyomkaset Numphung Rungraung Niramol Muangpracha Thunnalin Winuprasith Dunyaporn Trachootham |
| author_facet | Warisara Wongniyomkaset Numphung Rungraung Niramol Muangpracha Thunnalin Winuprasith Dunyaporn Trachootham |
| author_sort | Warisara Wongniyomkaset |
| collection | DOAJ |
| description | Complete nutrition drinks with a low glycemic index (GI) provide nutritional support and prevent hyperglycaemia. The present study identified GI and factors predicting individual glucose response to a new complete nutrition drink. A randomised cross-over controlled trial was conducted in eighteen healthy volunteers (FPG < 100 mg/dl). Complete nutrition drinks containing retrograded starch, glucose solution and white bread were assigned in a random sequence with 14-day wash-out intervals. Plasma glucose and insulin levels were measured from baseline to 180 min after consuming each food. Results show the adjusted GIs of the drink was 48.2 ± 10.4 and 46.7 ± 12.7 with glucose and white bread as the reference, respectively. While the drink has low GI (<55), the individual glucose responses varied (GI: 7–149). Comparing characters in individual GI < 55 (n = 12) and GI ≥ 55 (n = 6) groups revealed significantly higher baseline insulin in the low GI group (14.86 ± 16.51 μIU/ml v. 4.9 ± 3.4 μIU/ml, P < 0·05). The correlation matrix confirms only two predictive factors for having individual GI <55 were baseline insulin (r = 0·5, P = 0·03) and HOMA-IR (r = 0·55, P = 0·02). ROC curve reveals fasting insulin above 1.6 μIU/ml and HOMA-IR above 1.05 as the cut-off values. The findings suggest that the complete nutrition drink has a low GI, but there was wide variability in individual responses partly explained by fasting insulin levels and HOMA-IR. Screening for fasting insulin and HOMA-IR may be encouraged to maximise the functional benefit of the drink. |
| first_indexed | 2024-04-10T04:42:48Z |
| format | Article |
| id | doaj.art-53af463857a8460eb08d3d7e6f41d606 |
| institution | Directory Open Access Journal |
| issn | 2048-6790 |
| language | English |
| last_indexed | 2024-04-10T04:42:48Z |
| publishDate | 2022-01-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Journal of Nutritional Science |
| spelling | doaj.art-53af463857a8460eb08d3d7e6f41d6062023-03-09T12:38:46ZengCambridge University PressJournal of Nutritional Science2048-67902022-01-011110.1017/jns.2022.23Complete nutrition drink with retrograded starch is low glycemic, and the individual glucose response to the low glycemic complete nutrition drink depends on fasting insulin levels and HOMA-IR in a randomized cross-over control trialWarisara Wongniyomkaset0https://orcid.org/0000-0002-1626-652XNumphung Rungraung1https://orcid.org/0000-0002-8772-7354Niramol Muangpracha2https://orcid.org/0000-0003-3498-2033Thunnalin Winuprasith3https://orcid.org/0000-0002-5810-3956Dunyaporn Trachootham4https://orcid.org/0000-0002-6739-6295Master of Science Program in Nutrition and Dietetics, Institute of Nutrition, Mahidol University, Nakhon Pathom 73170, ThailandInstitute of Nutrition, Mahidol University, Nakhon Pathom 73170, ThailandInstitute of Nutrition, Mahidol University, Nakhon Pathom 73170, ThailandInstitute of Nutrition, Mahidol University, Nakhon Pathom 73170, ThailandInstitute of Nutrition, Mahidol University, Nakhon Pathom 73170, ThailandComplete nutrition drinks with a low glycemic index (GI) provide nutritional support and prevent hyperglycaemia. The present study identified GI and factors predicting individual glucose response to a new complete nutrition drink. A randomised cross-over controlled trial was conducted in eighteen healthy volunteers (FPG < 100 mg/dl). Complete nutrition drinks containing retrograded starch, glucose solution and white bread were assigned in a random sequence with 14-day wash-out intervals. Plasma glucose and insulin levels were measured from baseline to 180 min after consuming each food. Results show the adjusted GIs of the drink was 48.2 ± 10.4 and 46.7 ± 12.7 with glucose and white bread as the reference, respectively. While the drink has low GI (<55), the individual glucose responses varied (GI: 7–149). Comparing characters in individual GI < 55 (n = 12) and GI ≥ 55 (n = 6) groups revealed significantly higher baseline insulin in the low GI group (14.86 ± 16.51 μIU/ml v. 4.9 ± 3.4 μIU/ml, P < 0·05). The correlation matrix confirms only two predictive factors for having individual GI <55 were baseline insulin (r = 0·5, P = 0·03) and HOMA-IR (r = 0·55, P = 0·02). ROC curve reveals fasting insulin above 1.6 μIU/ml and HOMA-IR above 1.05 as the cut-off values. The findings suggest that the complete nutrition drink has a low GI, but there was wide variability in individual responses partly explained by fasting insulin levels and HOMA-IR. Screening for fasting insulin and HOMA-IR may be encouraged to maximise the functional benefit of the drink.https://www.cambridge.org/core/product/identifier/S2048679022000234/type/journal_articleClinical trialComplete nutrition drinkGlycemic indexHealthy volunteersInsulinPersonalised nutritionPostprandial glucose responseRetrograded starch |
| spellingShingle | Warisara Wongniyomkaset Numphung Rungraung Niramol Muangpracha Thunnalin Winuprasith Dunyaporn Trachootham Complete nutrition drink with retrograded starch is low glycemic, and the individual glucose response to the low glycemic complete nutrition drink depends on fasting insulin levels and HOMA-IR in a randomized cross-over control trial Journal of Nutritional Science Clinical trial Complete nutrition drink Glycemic index Healthy volunteers Insulin Personalised nutrition Postprandial glucose response Retrograded starch |
| title | Complete nutrition drink with retrograded starch is low glycemic, and the individual glucose response to the low glycemic complete nutrition drink depends on fasting insulin levels and HOMA-IR in a randomized cross-over control trial |
| title_full | Complete nutrition drink with retrograded starch is low glycemic, and the individual glucose response to the low glycemic complete nutrition drink depends on fasting insulin levels and HOMA-IR in a randomized cross-over control trial |
| title_fullStr | Complete nutrition drink with retrograded starch is low glycemic, and the individual glucose response to the low glycemic complete nutrition drink depends on fasting insulin levels and HOMA-IR in a randomized cross-over control trial |
| title_full_unstemmed | Complete nutrition drink with retrograded starch is low glycemic, and the individual glucose response to the low glycemic complete nutrition drink depends on fasting insulin levels and HOMA-IR in a randomized cross-over control trial |
| title_short | Complete nutrition drink with retrograded starch is low glycemic, and the individual glucose response to the low glycemic complete nutrition drink depends on fasting insulin levels and HOMA-IR in a randomized cross-over control trial |
| title_sort | complete nutrition drink with retrograded starch is low glycemic and the individual glucose response to the low glycemic complete nutrition drink depends on fasting insulin levels and homa ir in a randomized cross over control trial |
| topic | Clinical trial Complete nutrition drink Glycemic index Healthy volunteers Insulin Personalised nutrition Postprandial glucose response Retrograded starch |
| url | https://www.cambridge.org/core/product/identifier/S2048679022000234/type/journal_article |
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