Rosin maleic anhydride adduct antibacterial activity against methicillin-resistant Staphylococcus aureus
Abstract The emergence of antibiotic resistance in microorganisms is a serious challenge globally. Natural hydrophobic diterpene carboxylic acids present in rosin have unsatisfactory inhibitory properties against pathogens due to their poor water solubility. Therefore, the objective of research work...
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Polímeros
2020-09-01
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| Series: | Polímeros |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-14282020000200410&tlng=en |
| _version_ | 1798015437400702976 |
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| author | Zahid Majeed Muhammad Mushtaq Zainab Ajab Qingjie Guan Mater Hussen Mahnashi Yahya Saeed Alqahtani Basharat Ahmad |
| author_facet | Zahid Majeed Muhammad Mushtaq Zainab Ajab Qingjie Guan Mater Hussen Mahnashi Yahya Saeed Alqahtani Basharat Ahmad |
| author_sort | Zahid Majeed |
| collection | DOAJ |
| description | Abstract The emergence of antibiotic resistance in microorganisms is a serious challenge globally. Natural hydrophobic diterpene carboxylic acids present in rosin have unsatisfactory inhibitory properties against pathogens due to their poor water solubility. Therefore, the objective of research work was to modify the natural rosin into rosin maleic anhydride adduct with improved bioinhibitory properties for methicillin-resistant Staphylococcus aureus (MRSA). Prescreened MRSA isolates were found 78.05% and 29.27% resistant to oxacillin and vancomycin antibiotics respectively. The dosage effect of 0, 25, 50, and 100 mg L-1 rosin maleic anhydride adduct revealed the best inhibition response at 25 mg L-1. Moreover, bacteriostatic as well as the inhibitory effect of rosin maleic anhydride adduct was noticed against MRSA isolates. Gompertz model predicted better uptake of maleic anhydride adduct as compared to rosin. The higher specific growth rate of MRSA at reduced lag time correlated with increased toxicity of maleic anhydride adduct. This research concludes rosin maleic anhydride adduct has superior inhibitory properties against MRSA strains. |
| first_indexed | 2024-04-11T15:34:29Z |
| format | Article |
| id | doaj.art-53af824d38554a488b6e1c32791ef0d9 |
| institution | Directory Open Access Journal |
| issn | 1678-5169 |
| language | English |
| last_indexed | 2024-04-11T15:34:29Z |
| publishDate | 2020-09-01 |
| publisher | Associação Brasileira de Polímeros |
| record_format | Article |
| series | Polímeros |
| spelling | doaj.art-53af824d38554a488b6e1c32791ef0d92022-12-22T04:16:03ZengAssociação Brasileira de PolímerosPolímeros1678-51692020-09-0130210.1590/0104-1428.03820Rosin maleic anhydride adduct antibacterial activity against methicillin-resistant Staphylococcus aureusZahid Majeedhttps://orcid.org/0000-0002-9232-8219Muhammad Mushtaqhttps://orcid.org/0000-0003-0210-6055Zainab Ajabhttps://orcid.org/0000-0002-5681-2820Qingjie Guanhttps://orcid.org/0000-0002-9438-1427Mater Hussen Mahnashihttps://orcid.org/0000-0002-4837-3653Yahya Saeed Alqahtanihttps://orcid.org/0000-0001-8816-1842Basharat Ahmadhttps://orcid.org/0000-0003-0785-3076Abstract The emergence of antibiotic resistance in microorganisms is a serious challenge globally. Natural hydrophobic diterpene carboxylic acids present in rosin have unsatisfactory inhibitory properties against pathogens due to their poor water solubility. Therefore, the objective of research work was to modify the natural rosin into rosin maleic anhydride adduct with improved bioinhibitory properties for methicillin-resistant Staphylococcus aureus (MRSA). Prescreened MRSA isolates were found 78.05% and 29.27% resistant to oxacillin and vancomycin antibiotics respectively. The dosage effect of 0, 25, 50, and 100 mg L-1 rosin maleic anhydride adduct revealed the best inhibition response at 25 mg L-1. Moreover, bacteriostatic as well as the inhibitory effect of rosin maleic anhydride adduct was noticed against MRSA isolates. Gompertz model predicted better uptake of maleic anhydride adduct as compared to rosin. The higher specific growth rate of MRSA at reduced lag time correlated with increased toxicity of maleic anhydride adduct. This research concludes rosin maleic anhydride adduct has superior inhibitory properties against MRSA strains.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-14282020000200410&tlng=endrug resistancegrowth kineticsgrowth inhibitionMRSArosin maleic anhydride adduct |
| spellingShingle | Zahid Majeed Muhammad Mushtaq Zainab Ajab Qingjie Guan Mater Hussen Mahnashi Yahya Saeed Alqahtani Basharat Ahmad Rosin maleic anhydride adduct antibacterial activity against methicillin-resistant Staphylococcus aureus Polímeros drug resistance growth kinetics growth inhibition MRSA rosin maleic anhydride adduct |
| title | Rosin maleic anhydride adduct antibacterial activity against methicillin-resistant Staphylococcus aureus |
| title_full | Rosin maleic anhydride adduct antibacterial activity against methicillin-resistant Staphylococcus aureus |
| title_fullStr | Rosin maleic anhydride adduct antibacterial activity against methicillin-resistant Staphylococcus aureus |
| title_full_unstemmed | Rosin maleic anhydride adduct antibacterial activity against methicillin-resistant Staphylococcus aureus |
| title_short | Rosin maleic anhydride adduct antibacterial activity against methicillin-resistant Staphylococcus aureus |
| title_sort | rosin maleic anhydride adduct antibacterial activity against methicillin resistant staphylococcus aureus |
| topic | drug resistance growth kinetics growth inhibition MRSA rosin maleic anhydride adduct |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-14282020000200410&tlng=en |
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