Green synthesis of novel spiropyrazoline-indolinones in neutral deep eutectic solvents and DFT studies

Green synthesis of novel spiropyrazoline-indolinones in neutral deep eutectic solvents and DFT studies

Novel spiropyrazoline-indolinones (4a–t) have been synthesized successfully in neutral deep eutectic solvents by reacting 5-Cl/Br-isatin (1a–b) with aromatic ketones (2a–b) and a variety of substituted hydrazines (3a–e) in good to excellent yields. This eco-friendly straightforward synthetic protoco...

Full description

Bibliographic Details
Main Authors: Zubi Sadiq, Ambreen Ghani, Muhammad A. Hashmi, A. Dahshan, Shahnaz, Samiah H. Al-Mijalli, Munawar Iqbal, Erum A. Hussain
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Heliyon
Subjects:
Spiropyrazoline
Deep eutectic solvent
Intramolecular cyclization
Density functional theory
Online Access:http://www.sciencedirect.com/science/article/pii/S240584402311022X

Internet

http://www.sciencedirect.com/science/article/pii/S240584402311022X

Similar Items