Measurement of Arginase Activity in Sera of Iraqi Acromegaly Patients with Diabetes
The goal of this study was to measure arginase enzyme activity in diabetic acromegaly Iraqi patients and compare it to a control group. This study included 80 participants, whose ages ranged from 25 to 65, and was conducted on forty diabetic acromegaly Iraqi patients attending the national diabetes...
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| Format: | Article |
| Language: | English |
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Mustansiriyah University
2024-03-01
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| Series: | Al-Mustansiriyah Journal of Science |
| Subjects: | |
| Online Access: | https://mjs.uomustansiriyah.edu.iq/index.php/MJS/article/view/1362 |
| _version_ | 1827090612767162368 |
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| author | Fatima Khazaal Malek Salma Abdul_Rudha Abbas Baydaa Ahmed Abed |
| author_facet | Fatima Khazaal Malek Salma Abdul_Rudha Abbas Baydaa Ahmed Abed |
| author_sort | Fatima Khazaal Malek |
| collection | DOAJ |
| description |
The goal of this study was to measure arginase enzyme activity in diabetic acromegaly Iraqi patients and compare it to a control group. This study included 80 participants, whose ages ranged from 25 to 65, and was conducted on forty diabetic acromegaly Iraqi patients attending the national diabetes center of Mustansiriyah University in Baghdad and forty healthy individuals (as a control group). The results showed a highly significant reduction in arginase activity and High-density lipoprotein-cholesterol (HDL-C), Urea levels were reduced not significantly, whereas a highly significant increase in levels of Growth Hormone (GH), Insulin-Like Growth Factor-1 (IGF-1), Fasting Serum glucose (FSG), Total Cholesterol (TC), Triglycerides (TG), Low-density lipoprotein-cholesterol (LDL-C), and Very low-density lipoprotein-cholesterol (VLDL-C)) compared to control. A significant positive correlation was revealed between arginase activity and FSG levels in diabetic acromegaly patients. In conclusion, diabetic acromegaly patients had a significant decreased in serum arginase activity with no significant decrease urea levels, which indicates that their bodies store more nitrogen compounds to be utilized in constructing processes.
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| first_indexed | 2024-04-24T15:41:38Z |
| format | Article |
| id | doaj.art-53b43840afba4fec888d686439de19e5 |
| institution | Directory Open Access Journal |
| issn | 1814-635X 2521-3520 |
| language | English |
| last_indexed | 2025-03-20T05:43:11Z |
| publishDate | 2024-03-01 |
| publisher | Mustansiriyah University |
| record_format | Article |
| series | Al-Mustansiriyah Journal of Science |
| spelling | doaj.art-53b43840afba4fec888d686439de19e52024-10-03T04:29:24ZengMustansiriyah UniversityAl-Mustansiriyah Journal of Science1814-635X2521-35202024-03-0135110.23851/mjs.v35i1.1362Measurement of Arginase Activity in Sera of Iraqi Acromegaly Patients with DiabetesFatima Khazaal Malek0https://orcid.org/0009-0009-9268-123XSalma Abdul_Rudha Abbas1Baydaa Ahmed Abed2https://orcid.org/0000-0002-8895-7901Department of Chemistry, College of Science, Mustansiriyah University, 10052 Baghdad, IRAQ.Department of Chemistry, College of Science, Mustansiriyah University, 10052 Baghdad, IRAQ.Department of Chemistry, College of Science, Mustansiriyah University, 10052 Baghdad, IRAQ. National Diabetes Center, Mustansiriyah University, Baghdad, IRAQ. The goal of this study was to measure arginase enzyme activity in diabetic acromegaly Iraqi patients and compare it to a control group. This study included 80 participants, whose ages ranged from 25 to 65, and was conducted on forty diabetic acromegaly Iraqi patients attending the national diabetes center of Mustansiriyah University in Baghdad and forty healthy individuals (as a control group). The results showed a highly significant reduction in arginase activity and High-density lipoprotein-cholesterol (HDL-C), Urea levels were reduced not significantly, whereas a highly significant increase in levels of Growth Hormone (GH), Insulin-Like Growth Factor-1 (IGF-1), Fasting Serum glucose (FSG), Total Cholesterol (TC), Triglycerides (TG), Low-density lipoprotein-cholesterol (LDL-C), and Very low-density lipoprotein-cholesterol (VLDL-C)) compared to control. A significant positive correlation was revealed between arginase activity and FSG levels in diabetic acromegaly patients. In conclusion, diabetic acromegaly patients had a significant decreased in serum arginase activity with no significant decrease urea levels, which indicates that their bodies store more nitrogen compounds to be utilized in constructing processes. https://mjs.uomustansiriyah.edu.iq/index.php/MJS/article/view/1362AcromegalyGrowth HormoneInsulin-Like Growth Factor-1ArginaseDiabetes mellitusLipid profile |
| spellingShingle | Fatima Khazaal Malek Salma Abdul_Rudha Abbas Baydaa Ahmed Abed Measurement of Arginase Activity in Sera of Iraqi Acromegaly Patients with Diabetes Al-Mustansiriyah Journal of Science Acromegaly Growth Hormone Insulin-Like Growth Factor-1 Arginase Diabetes mellitus Lipid profile |
| title | Measurement of Arginase Activity in Sera of Iraqi Acromegaly Patients with Diabetes |
| title_full | Measurement of Arginase Activity in Sera of Iraqi Acromegaly Patients with Diabetes |
| title_fullStr | Measurement of Arginase Activity in Sera of Iraqi Acromegaly Patients with Diabetes |
| title_full_unstemmed | Measurement of Arginase Activity in Sera of Iraqi Acromegaly Patients with Diabetes |
| title_short | Measurement of Arginase Activity in Sera of Iraqi Acromegaly Patients with Diabetes |
| title_sort | measurement of arginase activity in sera of iraqi acromegaly patients with diabetes |
| topic | Acromegaly Growth Hormone Insulin-Like Growth Factor-1 Arginase Diabetes mellitus Lipid profile |
| url | https://mjs.uomustansiriyah.edu.iq/index.php/MJS/article/view/1362 |
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