Akkermansia muciniphila Protects Against Psychological Disorder-Induced Gut Microbiota-Mediated Colonic Mucosal Barrier Damage and Aggravation of Colitis
Psychological disorders are associated with increased risk of severe inflammatory bowel disease (IBD) by causing gut microbiota dysbiosis and colonic mucosal barrier damage. However, the interaction between chronic restraint stress (CRS), gut microbiota composition, and colonic mucus remains unclear...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-10-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2021.723856/full |
| _version_ | 1819151737905217536 |
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| author | Tuo Chen Rong Wang Zhenglan Duan Xiaomin Yuan Yang Ding Zeyu Feng Fan Bu Li Liu Qiong Wang Jinyong Zhou Lei Zhu Qing Ni Guoping Shi Yugen Chen |
| author_facet | Tuo Chen Rong Wang Zhenglan Duan Xiaomin Yuan Yang Ding Zeyu Feng Fan Bu Li Liu Qiong Wang Jinyong Zhou Lei Zhu Qing Ni Guoping Shi Yugen Chen |
| author_sort | Tuo Chen |
| collection | DOAJ |
| description | Psychological disorders are associated with increased risk of severe inflammatory bowel disease (IBD) by causing gut microbiota dysbiosis and colonic mucosal barrier damage. However, the interaction between chronic restraint stress (CRS), gut microbiota composition, and colonic mucus remains unclear. We demonstrated that mice under CRS conditions exhibited alterations in microbiota composition, disruption of colonic mucus, and aggravation of colitis. In addition, the abundance of Akkermansia muciniphila was significantly decreased in mice under CRS and UC patients with depression, and positively associated with the expression of MUC2. After antibiotic treatment, the recipient mice colonized with CRS microbiota showed barrier defects and severe colitis. Administration of Akkermansia muciniphila was found to restore colonic mucus and modify the gut microbiota. We confirm that CRS-mediated gut microbiota dysbiosis results in colonic mucosal barrier damage and aggravation of colitis. Our results suggest that A. muciniphila is expected to be a potential probiotic to protect and treat colonic mucus that is involved in IBD with psychological disorders. |
| first_indexed | 2024-12-22T14:38:10Z |
| format | Article |
| id | doaj.art-53b4a8cb71c44c60b855ef5520abfb32 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-12-22T14:38:10Z |
| publishDate | 2021-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-53b4a8cb71c44c60b855ef5520abfb322022-12-21T18:22:36ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882021-10-011110.3389/fcimb.2021.723856723856Akkermansia muciniphila Protects Against Psychological Disorder-Induced Gut Microbiota-Mediated Colonic Mucosal Barrier Damage and Aggravation of ColitisTuo Chen0Rong Wang1Zhenglan Duan2Xiaomin Yuan3Yang Ding4Zeyu Feng5Fan Bu6Li Liu7Qiong Wang8Jinyong Zhou9Lei Zhu10Qing Ni11Guoping Shi12Yugen Chen13Department of General Surgery, Affiliated Hospital of Yangzhou University, Yangzhou, ChinaDepartment of Colorectal Surgery, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, ChinaDepartment of Colorectal Surgery, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, ChinaDepartment of Colorectal Surgery, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, ChinaDepartment of Colorectal Surgery, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, ChinaDepartment of Colorectal Surgery, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, ChinaDepartment of Colorectal Surgery, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China Glycomics and Glycan Bioengineering Research Center, College of Food Science and Technology, Nanjing Agricultural University, Nanjing, ChinaBasic Pharmacology Laboratory, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, ChinaCentral Laboratory, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, ChinaCollaborative Innovation Center for Cancer Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, ChinaDepartment of General Surgery, Affiliated Hospital of Yangzhou University, Yangzhou, ChinaCollaborative Innovation Center for Cancer Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, ChinaDepartment of Colorectal Surgery, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, ChinaPsychological disorders are associated with increased risk of severe inflammatory bowel disease (IBD) by causing gut microbiota dysbiosis and colonic mucosal barrier damage. However, the interaction between chronic restraint stress (CRS), gut microbiota composition, and colonic mucus remains unclear. We demonstrated that mice under CRS conditions exhibited alterations in microbiota composition, disruption of colonic mucus, and aggravation of colitis. In addition, the abundance of Akkermansia muciniphila was significantly decreased in mice under CRS and UC patients with depression, and positively associated with the expression of MUC2. After antibiotic treatment, the recipient mice colonized with CRS microbiota showed barrier defects and severe colitis. Administration of Akkermansia muciniphila was found to restore colonic mucus and modify the gut microbiota. We confirm that CRS-mediated gut microbiota dysbiosis results in colonic mucosal barrier damage and aggravation of colitis. Our results suggest that A. muciniphila is expected to be a potential probiotic to protect and treat colonic mucus that is involved in IBD with psychological disorders.https://www.frontiersin.org/articles/10.3389/fcimb.2021.723856/fullchronic restraint stresscolitiscolonic mucusfecal microbiota transplantationAkkermansia muciniphila |
| spellingShingle | Tuo Chen Rong Wang Zhenglan Duan Xiaomin Yuan Yang Ding Zeyu Feng Fan Bu Li Liu Qiong Wang Jinyong Zhou Lei Zhu Qing Ni Guoping Shi Yugen Chen Akkermansia muciniphila Protects Against Psychological Disorder-Induced Gut Microbiota-Mediated Colonic Mucosal Barrier Damage and Aggravation of Colitis Frontiers in Cellular and Infection Microbiology chronic restraint stress colitis colonic mucus fecal microbiota transplantation Akkermansia muciniphila |
| title | Akkermansia muciniphila Protects Against Psychological Disorder-Induced Gut Microbiota-Mediated Colonic Mucosal Barrier Damage and Aggravation of Colitis |
| title_full | Akkermansia muciniphila Protects Against Psychological Disorder-Induced Gut Microbiota-Mediated Colonic Mucosal Barrier Damage and Aggravation of Colitis |
| title_fullStr | Akkermansia muciniphila Protects Against Psychological Disorder-Induced Gut Microbiota-Mediated Colonic Mucosal Barrier Damage and Aggravation of Colitis |
| title_full_unstemmed | Akkermansia muciniphila Protects Against Psychological Disorder-Induced Gut Microbiota-Mediated Colonic Mucosal Barrier Damage and Aggravation of Colitis |
| title_short | Akkermansia muciniphila Protects Against Psychological Disorder-Induced Gut Microbiota-Mediated Colonic Mucosal Barrier Damage and Aggravation of Colitis |
| title_sort | akkermansia muciniphila protects against psychological disorder induced gut microbiota mediated colonic mucosal barrier damage and aggravation of colitis |
| topic | chronic restraint stress colitis colonic mucus fecal microbiota transplantation Akkermansia muciniphila |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2021.723856/full |
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