Disposition kinetics of sparfloxacin under different pathological condition in Black Bengal goat following single intravenous administration
Clinically healthy 9 black Bengal female goats (1–1.5 year age) weighing between 9–12 kg were divided into 3 equal groups. Group 1 served as control and the animals of group 2 and 3 were considered to be experimental. In experiment no. 1 sparfloxacin was administered intravenously to the goats of g...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Indian Council of Agricultural Research
2014-08-01
|
| Series: | Indian Journal of Animal Sciences |
| Subjects: | |
| Online Access: | https://epubs.icar.org.in/index.php/IJAnS/article/view/43212 |
| _version_ | 1797643392707985408 |
|---|---|
| author | ABUL HASAN MD ABIDUR RAHAMAN MADHUCHHAANDA KHAN TAPAN KUMAR MANDAL |
| author_facet | ABUL HASAN MD ABIDUR RAHAMAN MADHUCHHAANDA KHAN TAPAN KUMAR MANDAL |
| author_sort | ABUL HASAN MD ABIDUR RAHAMAN |
| collection | DOAJ |
| description |
Clinically healthy 9 black Bengal female goats (1–1.5 year age) weighing between 9–12 kg were divided into 3 equal groups. Group 1 served as control and the animals of group 2 and 3 were considered to be experimental. In experiment no. 1 sparfloxacin was administered intravenously to the goats of group 1 and disposition kinetics and protein binding studies were conducted in plasma. Liver of each goat of group 2 and 3 were damaged by subcutaneous administration of carbontetrachloride and considered as experiment no.2. Sparfloxacin was administered intravenously to group 2 for disposition kinetics and protein binding study. In experiment no.3 rejuvenation of liver of animals of group 2 were done by oral administration of a commercial medicine for consecutive 21 days period. Animals of group 3 were considered as untreated control for the commercial medicine. The results of icterus index, bromosulphophthalein clearance, serum transaminase activity suggested that carbontetrachloride at the recommended dose level produced hepatopathy of goats. The commercial medicine treatment brought all the altered values of plasma kinetic parameters to base level and regenerated the damaged tissue of liver. Disposition kinetic study of sparfloxacin showed that carbontetrachloride –induced damage liver retained Sparfloxacin for same period with almost equi concentration.
|
| first_indexed | 2024-03-11T14:14:07Z |
| format | Article |
| id | doaj.art-53b5140513c14be89939b0da76f82e61 |
| institution | Directory Open Access Journal |
| issn | 0367-8318 2394-3327 |
| language | English |
| last_indexed | 2024-03-11T14:14:07Z |
| publishDate | 2014-08-01 |
| publisher | Indian Council of Agricultural Research |
| record_format | Article |
| series | Indian Journal of Animal Sciences |
| spelling | doaj.art-53b5140513c14be89939b0da76f82e612023-11-01T11:01:41ZengIndian Council of Agricultural ResearchIndian Journal of Animal Sciences0367-83182394-33272014-08-0184810.56093/ijans.v84i8.43212Disposition kinetics of sparfloxacin under different pathological condition in Black Bengal goat following single intravenous administrationABUL HASAN MD ABIDUR RAHAMAN0MADHUCHHAANDA KHAN1TAPAN KUMAR MANDAL2West Bengal University of Animal and Fishery Sciences, 37, Kshudiram Bose Sarani, Kolkata,West Bengal 737 007 IndiaWest Bengal University of Animal and Fishery Sciences, 37, Kshudiram Bose Sarani, Kolkata,West Bengal 737 007 IndiaWest Bengal University of Animal and Fishery Sciences, 37, Kshudiram Bose Sarani, Kolkata,West Bengal 737 007 India Clinically healthy 9 black Bengal female goats (1–1.5 year age) weighing between 9–12 kg were divided into 3 equal groups. Group 1 served as control and the animals of group 2 and 3 were considered to be experimental. In experiment no. 1 sparfloxacin was administered intravenously to the goats of group 1 and disposition kinetics and protein binding studies were conducted in plasma. Liver of each goat of group 2 and 3 were damaged by subcutaneous administration of carbontetrachloride and considered as experiment no.2. Sparfloxacin was administered intravenously to group 2 for disposition kinetics and protein binding study. In experiment no.3 rejuvenation of liver of animals of group 2 were done by oral administration of a commercial medicine for consecutive 21 days period. Animals of group 3 were considered as untreated control for the commercial medicine. The results of icterus index, bromosulphophthalein clearance, serum transaminase activity suggested that carbontetrachloride at the recommended dose level produced hepatopathy of goats. The commercial medicine treatment brought all the altered values of plasma kinetic parameters to base level and regenerated the damaged tissue of liver. Disposition kinetic study of sparfloxacin showed that carbontetrachloride –induced damage liver retained Sparfloxacin for same period with almost equi concentration. https://epubs.icar.org.in/index.php/IJAnS/article/view/43212CarbontetrachlorideDisposition kineticsGoatsHepatopathySparfloxacin |
| spellingShingle | ABUL HASAN MD ABIDUR RAHAMAN MADHUCHHAANDA KHAN TAPAN KUMAR MANDAL Disposition kinetics of sparfloxacin under different pathological condition in Black Bengal goat following single intravenous administration Indian Journal of Animal Sciences Carbontetrachloride Disposition kinetics Goats Hepatopathy Sparfloxacin |
| title | Disposition kinetics of sparfloxacin under different pathological condition in Black Bengal goat following single intravenous administration |
| title_full | Disposition kinetics of sparfloxacin under different pathological condition in Black Bengal goat following single intravenous administration |
| title_fullStr | Disposition kinetics of sparfloxacin under different pathological condition in Black Bengal goat following single intravenous administration |
| title_full_unstemmed | Disposition kinetics of sparfloxacin under different pathological condition in Black Bengal goat following single intravenous administration |
| title_short | Disposition kinetics of sparfloxacin under different pathological condition in Black Bengal goat following single intravenous administration |
| title_sort | disposition kinetics of sparfloxacin under different pathological condition in black bengal goat following single intravenous administration |
| topic | Carbontetrachloride Disposition kinetics Goats Hepatopathy Sparfloxacin |
| url | https://epubs.icar.org.in/index.php/IJAnS/article/view/43212 |
| work_keys_str_mv | AT abulhasanmdabidurrahaman dispositionkineticsofsparfloxacinunderdifferentpathologicalconditioninblackbengalgoatfollowingsingleintravenousadministration AT madhuchhaandakhan dispositionkineticsofsparfloxacinunderdifferentpathologicalconditioninblackbengalgoatfollowingsingleintravenousadministration AT tapankumarmandal dispositionkineticsofsparfloxacinunderdifferentpathologicalconditioninblackbengalgoatfollowingsingleintravenousadministration |