Long-term survival of patients with locally advanced esophageal squamous cell carcinoma receiving esophagectomy following neoadjuvant chemotherapy: a cohort study
Zekai Huang,1,* Shaolei Li,1,* Xin Yang,2 Fangliang Lu,1 Miao Huang,1 Shanyuan Zhang,1 Ying Xiong,1 Panpan Zhang,1 Jiahui Si,1 Yuanyuan Ma,1 Yue Yang1 1Department of Thoracic Surgery II, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hos...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2019-02-01
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| Series: | Cancer Management and Research |
| Subjects: | |
| Online Access: | https://www.dovepress.com/long-term-survival-of-patients-with-locally-advanced-esophageal-squamo-peer-reviewed-article-CMAR |
| _version_ | 1828780494061305856 |
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| author | Huang Z Li S Yang X Lu F Huang M Zhang S Xiong Y Zhang P Si J Ma Y Yang Y |
| author_facet | Huang Z Li S Yang X Lu F Huang M Zhang S Xiong Y Zhang P Si J Ma Y Yang Y |
| author_sort | Huang Z |
| collection | DOAJ |
| description | Zekai Huang,1,* Shaolei Li,1,* Xin Yang,2 Fangliang Lu,1 Miao Huang,1 Shanyuan Zhang,1 Ying Xiong,1 Panpan Zhang,1 Jiahui Si,1 Yuanyuan Ma,1 Yue Yang1 1Department of Thoracic Surgery II, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing 100142, China; 2Department of Pathology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing 100142, China *These authors contributed equally to this work Purpose: The role of neoadjuvant chemotherapy and subsequent adjuvant therapy in the treatment of patients with locally advanced esophageal squamous cell carcinomas (ESCC) is not well established.Patients and methods: We retrospectively reviewed 228 patients with locally advanced ESCC receiving esophagectomy following neoadjuvant chemotherapy from January 2007 through December 2016. The probabilities of disease-free survival (DFS) and overall survival (OS) were estimated by means of the Kaplan–Meier method and were compared with the use of the log-rank test. Univariate and multivariate analyses of predictors of DFS and OS were performed using a Cox proportional-hazards model. Propensity score matching analysis was performed for further analysis regarding the benefit of adjuvant therapy.Results: The pathological complete response of neoadjuvant chemotherapy was achieved in 13 of 228 patients (5.7%). With a median follow-up of 59.6 months, the median DFS and OS were 35.4 and 45.4 months, respectively. The multivariate Cox model determined chemotherapy regimens (P=0.003) and ypT category (P=0.006) were significant independent predictors of DFS; and chemotherapy regimens (P=0.001), ypT category (P<0.001), and ypN category (P=0.013) were significant independent predictors of OS. Furthermore, patients who received adjuvant therapy seemed to be associated with poorer survival (both DFS and OS) compared with those who did not in full cohort (P=0.001 and P=0.184, respectively) and matched cohort (P=0.251 and P=0.374, respectively).Conclusion: Surgery following neoadjuvant chemotherapy was applicable. Chemotherapy regimens and ypT category were significant independent predictors of both DFS and OS and ypN category was also a significant independent predictor of OS. However, these patients did not seem to benefit from subsequent adjuvant therapy. The necessity of adjuvant therapy requires further investigation. Keywords: locally advanced esophageal squamous cell carcinoma, neoadjuvant chemotherapy, surgery, adjuvant therapy |
| first_indexed | 2024-12-11T17:18:56Z |
| format | Article |
| id | doaj.art-53b56cccfdd94e69bde6b65e0fd63f52 |
| institution | Directory Open Access Journal |
| issn | 1179-1322 |
| language | English |
| last_indexed | 2024-12-11T17:18:56Z |
| publishDate | 2019-02-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Cancer Management and Research |
| spelling | doaj.art-53b56cccfdd94e69bde6b65e0fd63f522022-12-22T00:57:13ZengDove Medical PressCancer Management and Research1179-13222019-02-01Volume 111299130843972Long-term survival of patients with locally advanced esophageal squamous cell carcinoma receiving esophagectomy following neoadjuvant chemotherapy: a cohort studyHuang ZLi SYang XLu FHuang MZhang SXiong YZhang PSi JMa YYang YZekai Huang,1,* Shaolei Li,1,* Xin Yang,2 Fangliang Lu,1 Miao Huang,1 Shanyuan Zhang,1 Ying Xiong,1 Panpan Zhang,1 Jiahui Si,1 Yuanyuan Ma,1 Yue Yang1 1Department of Thoracic Surgery II, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing 100142, China; 2Department of Pathology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing 100142, China *These authors contributed equally to this work Purpose: The role of neoadjuvant chemotherapy and subsequent adjuvant therapy in the treatment of patients with locally advanced esophageal squamous cell carcinomas (ESCC) is not well established.Patients and methods: We retrospectively reviewed 228 patients with locally advanced ESCC receiving esophagectomy following neoadjuvant chemotherapy from January 2007 through December 2016. The probabilities of disease-free survival (DFS) and overall survival (OS) were estimated by means of the Kaplan–Meier method and were compared with the use of the log-rank test. Univariate and multivariate analyses of predictors of DFS and OS were performed using a Cox proportional-hazards model. Propensity score matching analysis was performed for further analysis regarding the benefit of adjuvant therapy.Results: The pathological complete response of neoadjuvant chemotherapy was achieved in 13 of 228 patients (5.7%). With a median follow-up of 59.6 months, the median DFS and OS were 35.4 and 45.4 months, respectively. The multivariate Cox model determined chemotherapy regimens (P=0.003) and ypT category (P=0.006) were significant independent predictors of DFS; and chemotherapy regimens (P=0.001), ypT category (P<0.001), and ypN category (P=0.013) were significant independent predictors of OS. Furthermore, patients who received adjuvant therapy seemed to be associated with poorer survival (both DFS and OS) compared with those who did not in full cohort (P=0.001 and P=0.184, respectively) and matched cohort (P=0.251 and P=0.374, respectively).Conclusion: Surgery following neoadjuvant chemotherapy was applicable. Chemotherapy regimens and ypT category were significant independent predictors of both DFS and OS and ypN category was also a significant independent predictor of OS. However, these patients did not seem to benefit from subsequent adjuvant therapy. The necessity of adjuvant therapy requires further investigation. Keywords: locally advanced esophageal squamous cell carcinoma, neoadjuvant chemotherapy, surgery, adjuvant therapyhttps://www.dovepress.com/long-term-survival-of-patients-with-locally-advanced-esophageal-squamo-peer-reviewed-article-CMARlocally advanced esophageal squamous cell carcinomaneoadjuvant chemotherapysurgeryadjuvant therapy |
| spellingShingle | Huang Z Li S Yang X Lu F Huang M Zhang S Xiong Y Zhang P Si J Ma Y Yang Y Long-term survival of patients with locally advanced esophageal squamous cell carcinoma receiving esophagectomy following neoadjuvant chemotherapy: a cohort study Cancer Management and Research locally advanced esophageal squamous cell carcinoma neoadjuvant chemotherapy surgery adjuvant therapy |
| title | Long-term survival of patients with locally advanced esophageal squamous cell carcinoma receiving esophagectomy following neoadjuvant chemotherapy: a cohort study |
| title_full | Long-term survival of patients with locally advanced esophageal squamous cell carcinoma receiving esophagectomy following neoadjuvant chemotherapy: a cohort study |
| title_fullStr | Long-term survival of patients with locally advanced esophageal squamous cell carcinoma receiving esophagectomy following neoadjuvant chemotherapy: a cohort study |
| title_full_unstemmed | Long-term survival of patients with locally advanced esophageal squamous cell carcinoma receiving esophagectomy following neoadjuvant chemotherapy: a cohort study |
| title_short | Long-term survival of patients with locally advanced esophageal squamous cell carcinoma receiving esophagectomy following neoadjuvant chemotherapy: a cohort study |
| title_sort | long term survival of patients with locally advanced esophageal squamous cell carcinoma receiving esophagectomy following neoadjuvant chemotherapy a cohort study |
| topic | locally advanced esophageal squamous cell carcinoma neoadjuvant chemotherapy surgery adjuvant therapy |
| url | https://www.dovepress.com/long-term-survival-of-patients-with-locally-advanced-esophageal-squamo-peer-reviewed-article-CMAR |
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