History of international connections of myology in Europe
Over the past centuries, myology as a basic and clinical science has passed through three major stages of development: the classical period, the modern nosographic stage, and the molecular era. The classical period spans the sixteenth century up to the earlier parts of the twentieth century. During...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2023-07-01
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| Series: | European Journal of Translational Myology |
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| Online Access: | https://www.pagepressjournals.org/index.php/bam/article/view/11439 |
| _version_ | 1797783654819168256 |
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| author | Corrado Angelini |
| author_facet | Corrado Angelini |
| author_sort | Corrado Angelini |
| collection | DOAJ |
| description |
Over the past centuries, myology as a basic and clinical science has passed through three major stages of development: the classical period, the modern nosographic stage, and the molecular era. The classical period spans the sixteenth century up to the earlier parts of the twentieth century. During this time, several major muscle diseases were clinically and pathologically characterized, including Duchenne muscular dystrophy (DMD), myotonic dystrophy, and facio-scapulo-humeral dystrophy, by master clinicians such as Duchenne, Erb, Becker, Steinert, Landouzy, Dejerine, Meryon, and others. These accomplishments laid solid foundations for the following modern era with nosographic classification and the following molecular era. European clinicians and scientists were major contributors to the modern era in the second half of the twentieth century, which is characterized by three major discoveries. First, it was observed that substantial elevation of the serum activity of creatine kinase indicates muscle damage or destruction. Then, the adaptation of modern histo-and cytochemical techniques to the study of muscle biopsies markedly improved the diagnostic accuracy and made possible the identification of new changes and structures. Thirdly, the advent of modern biochemical techniques permitted the identification of various enzyme defects/storage diseases such as Pompe disease, McArdle's disease, and carnitine deficiency states. The molecular era was made possible by the strikingly fast development of molecular biology and its application to muscle diseases. This permitted the identification of gene defects in many inherited diseases, leading to an accurate and specific diagnosis. The growth of international collaboration in Europe was achieved through the exchange of international scientists and collaborative networks.
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| first_indexed | 2024-03-13T00:28:58Z |
| format | Article |
| id | doaj.art-53b7d20440324cd2b4ffa626c2f32989 |
| institution | Directory Open Access Journal |
| issn | 2037-7452 2037-7460 |
| language | English |
| last_indexed | 2024-03-13T00:28:58Z |
| publishDate | 2023-07-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | European Journal of Translational Myology |
| spelling | doaj.art-53b7d20440324cd2b4ffa626c2f329892023-07-10T22:51:56ZengPAGEPress PublicationsEuropean Journal of Translational Myology2037-74522037-74602023-07-0110.4081/ejtm.2023.11439History of international connections of myology in EuropeCorrado Angelini0Department of Neuroscience, University of Padova, Padua Over the past centuries, myology as a basic and clinical science has passed through three major stages of development: the classical period, the modern nosographic stage, and the molecular era. The classical period spans the sixteenth century up to the earlier parts of the twentieth century. During this time, several major muscle diseases were clinically and pathologically characterized, including Duchenne muscular dystrophy (DMD), myotonic dystrophy, and facio-scapulo-humeral dystrophy, by master clinicians such as Duchenne, Erb, Becker, Steinert, Landouzy, Dejerine, Meryon, and others. These accomplishments laid solid foundations for the following modern era with nosographic classification and the following molecular era. European clinicians and scientists were major contributors to the modern era in the second half of the twentieth century, which is characterized by three major discoveries. First, it was observed that substantial elevation of the serum activity of creatine kinase indicates muscle damage or destruction. Then, the adaptation of modern histo-and cytochemical techniques to the study of muscle biopsies markedly improved the diagnostic accuracy and made possible the identification of new changes and structures. Thirdly, the advent of modern biochemical techniques permitted the identification of various enzyme defects/storage diseases such as Pompe disease, McArdle's disease, and carnitine deficiency states. The molecular era was made possible by the strikingly fast development of molecular biology and its application to muscle diseases. This permitted the identification of gene defects in many inherited diseases, leading to an accurate and specific diagnosis. The growth of international collaboration in Europe was achieved through the exchange of international scientists and collaborative networks. https://www.pagepressjournals.org/index.php/bam/article/view/11439muscle dystrophymitochondrial disorderslimb-girdle dystrophyfacio-scapulo-humeral dystrophymetabolic myopathies |
| spellingShingle | Corrado Angelini History of international connections of myology in Europe European Journal of Translational Myology muscle dystrophy mitochondrial disorders limb-girdle dystrophy facio-scapulo-humeral dystrophy metabolic myopathies |
| title | History of international connections of myology in Europe |
| title_full | History of international connections of myology in Europe |
| title_fullStr | History of international connections of myology in Europe |
| title_full_unstemmed | History of international connections of myology in Europe |
| title_short | History of international connections of myology in Europe |
| title_sort | history of international connections of myology in europe |
| topic | muscle dystrophy mitochondrial disorders limb-girdle dystrophy facio-scapulo-humeral dystrophy metabolic myopathies |
| url | https://www.pagepressjournals.org/index.php/bam/article/view/11439 |
| work_keys_str_mv | AT corradoangelini historyofinternationalconnectionsofmyologyineurope |