Efficacy of high-dose ambroxol for paraquat poisoning: A meta-analysis of randomized controlled trials
Background: Paraquat (PQ) poisoning is characterized by rapidly progressive acute poisoning with high mortality and no specific antidote. Although some clinical studies have been conducted to investigate the benefits of high-dose ambroxol as an adjuvant treatment for PQ poisoning, the efficacy is co...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2020-01-01
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| Series: | Journal of Research in Medical Sciences |
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| Online Access: | http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2020;volume=25;issue=1;spage=67;epage=67;aulast=Wang |
| _version_ | 1828282641944674304 |
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| author | Junwu Wang Wensu Yu Na Wu Elaine N Gitonga Haitao Shen |
| author_facet | Junwu Wang Wensu Yu Na Wu Elaine N Gitonga Haitao Shen |
| author_sort | Junwu Wang |
| collection | DOAJ |
| description | Background: Paraquat (PQ) poisoning is characterized by rapidly progressive acute poisoning with high mortality and no specific antidote. Although some clinical studies have been conducted to investigate the benefits of high-dose ambroxol as an adjuvant treatment for PQ poisoning, the efficacy is controversial. Materials and Methods: After searching for relevant articles in English and Chinese databases from 1978 to 2019 according to the keywords (paraquat poisoning/methy viologen/gramoxone, and ambroxol/mucosolvan/Bromhexine), we found seven articles that met our inclusion and exclusion criteria. A meta-analysis was performed using fixed-effects model and random-effects model according to the I2 value in Stata software (version 15.0). Four outcome indicators (hospital mortality, partial pressure of oxygen (PaO2), oxygenation index (PaO2/FiO2), and survival time of the deceased patients) were of interest to us. Results: The meta-analysis showed that adjuvant treatment with high doses of ambroxol increased PaO2(weighted mean difference [WMD] = 13.73 [mmHg], 95% confidence interval [CI]: 8.68–18.79, Z = 11.80, P < 0.001), PaO2/FiO2(WMD = 38.81 [mmHg], 95% CI: 29.85–47.76, Z = 8.49, P = 0.000), and survival time of the deceased patients (WMD = 2.58 [d], 95% CI: 0.97–4.18, Z = 3.15, P = 0.002) compared with usual treatment. Treatment with high doses of ambroxol also appeared to reduce the hospital mortality (relative risk = 0.69, 95% CI: 0.55–0.86, Z = 3.25, P = 0.001). Conclusion: This study found that high-dose ambroxol is an effective therapy for PQ poisoning and may reduce the in-hospital mortality. |
| first_indexed | 2024-04-13T08:32:13Z |
| format | Article |
| id | doaj.art-53b7f6edf2fe4c64a62e2c79b4de0524 |
| institution | Directory Open Access Journal |
| issn | 1735-1995 1735-7136 |
| language | English |
| last_indexed | 2024-04-13T08:32:13Z |
| publishDate | 2020-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Research in Medical Sciences |
| spelling | doaj.art-53b7f6edf2fe4c64a62e2c79b4de05242022-12-22T02:54:13ZengWolters Kluwer Medknow PublicationsJournal of Research in Medical Sciences1735-19951735-71362020-01-01251676710.4103/jrms.JRMS_484_19Efficacy of high-dose ambroxol for paraquat poisoning: A meta-analysis of randomized controlled trialsJunwu WangWensu YuNa WuElaine N GitongaHaitao ShenBackground: Paraquat (PQ) poisoning is characterized by rapidly progressive acute poisoning with high mortality and no specific antidote. Although some clinical studies have been conducted to investigate the benefits of high-dose ambroxol as an adjuvant treatment for PQ poisoning, the efficacy is controversial. Materials and Methods: After searching for relevant articles in English and Chinese databases from 1978 to 2019 according to the keywords (paraquat poisoning/methy viologen/gramoxone, and ambroxol/mucosolvan/Bromhexine), we found seven articles that met our inclusion and exclusion criteria. A meta-analysis was performed using fixed-effects model and random-effects model according to the I2 value in Stata software (version 15.0). Four outcome indicators (hospital mortality, partial pressure of oxygen (PaO2), oxygenation index (PaO2/FiO2), and survival time of the deceased patients) were of interest to us. Results: The meta-analysis showed that adjuvant treatment with high doses of ambroxol increased PaO2(weighted mean difference [WMD] = 13.73 [mmHg], 95% confidence interval [CI]: 8.68–18.79, Z = 11.80, P < 0.001), PaO2/FiO2(WMD = 38.81 [mmHg], 95% CI: 29.85–47.76, Z = 8.49, P = 0.000), and survival time of the deceased patients (WMD = 2.58 [d], 95% CI: 0.97–4.18, Z = 3.15, P = 0.002) compared with usual treatment. Treatment with high doses of ambroxol also appeared to reduce the hospital mortality (relative risk = 0.69, 95% CI: 0.55–0.86, Z = 3.25, P = 0.001). Conclusion: This study found that high-dose ambroxol is an effective therapy for PQ poisoning and may reduce the in-hospital mortality.http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2020;volume=25;issue=1;spage=67;epage=67;aulast=Wanghigh-dose ambroxolmeta-analysisparaquat poisoning |
| spellingShingle | Junwu Wang Wensu Yu Na Wu Elaine N Gitonga Haitao Shen Efficacy of high-dose ambroxol for paraquat poisoning: A meta-analysis of randomized controlled trials Journal of Research in Medical Sciences high-dose ambroxol meta-analysis paraquat poisoning |
| title | Efficacy of high-dose ambroxol for paraquat poisoning: A meta-analysis of randomized controlled trials |
| title_full | Efficacy of high-dose ambroxol for paraquat poisoning: A meta-analysis of randomized controlled trials |
| title_fullStr | Efficacy of high-dose ambroxol for paraquat poisoning: A meta-analysis of randomized controlled trials |
| title_full_unstemmed | Efficacy of high-dose ambroxol for paraquat poisoning: A meta-analysis of randomized controlled trials |
| title_short | Efficacy of high-dose ambroxol for paraquat poisoning: A meta-analysis of randomized controlled trials |
| title_sort | efficacy of high dose ambroxol for paraquat poisoning a meta analysis of randomized controlled trials |
| topic | high-dose ambroxol meta-analysis paraquat poisoning |
| url | http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2020;volume=25;issue=1;spage=67;epage=67;aulast=Wang |
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