Trimethyl Lock Quinone-Based Organic Molecular Probes for NQO1 Sensing and Imaging
NAD(P)H: quinone oxidoreductase isozyme 1 (NQO1) is a flavoenzyme and involved in protection against oxidative stress and the regulation of metabolic functions, which is strongly implicated in neurodegenerative diseases and carcinogenic processes. Furthermore, NQO1 is also involved in the modes of a...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Chemosensors |
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| Online Access: | https://www.mdpi.com/2227-9040/11/4/221 |
| _version_ | 1827745504743653376 |
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| author | Kun Chen Shuai Xu Zhiling Song Ke Li |
| author_facet | Kun Chen Shuai Xu Zhiling Song Ke Li |
| author_sort | Kun Chen |
| collection | DOAJ |
| description | NAD(P)H: quinone oxidoreductase isozyme 1 (NQO1) is a flavoenzyme and involved in protection against oxidative stress and the regulation of metabolic functions, which is strongly implicated in neurodegenerative diseases and carcinogenic processes. Furthermore, NQO1 is also involved in the modes of action of redox-active drugs (e.g., antimalarials). Determining the activity and localization of NQO1 in living organisms is of great importance for early disease diagnosis and therapy. As a promising and convenient biosensing technique, trimethyl lock quinone-based organic molecular probes have been well established for the specific detection and imaging of NQO1 in living cells and in vivo. In this review, the recent progress of NQO1 probes based on organic small molecules is summarized from the perspectives of molecular design strategies, sensing mechanisms and bioimaging applications. We also elucidate the potential limitations and prospects of current NQO1 probes to further promote the development of versatile imaging tools for NQO1-related biomedical investigation. |
| first_indexed | 2024-03-11T05:07:56Z |
| format | Article |
| id | doaj.art-53b869a13a88405cb39058910a65a68a |
| institution | Directory Open Access Journal |
| issn | 2227-9040 |
| language | English |
| last_indexed | 2024-03-11T05:07:56Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Chemosensors |
| spelling | doaj.art-53b869a13a88405cb39058910a65a68a2023-11-17T18:44:36ZengMDPI AGChemosensors2227-90402023-04-0111422110.3390/chemosensors11040221Trimethyl Lock Quinone-Based Organic Molecular Probes for NQO1 Sensing and ImagingKun Chen0Shuai Xu1Zhiling Song2Ke Li3College of Chemistry & Chemical Engineering, Central South University, Changsha 410083, ChinaState Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, ChinaShandong Key Laboratory of Biochemical Analysis, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, ChinaCollege of Chemistry & Chemical Engineering, Central South University, Changsha 410083, ChinaNAD(P)H: quinone oxidoreductase isozyme 1 (NQO1) is a flavoenzyme and involved in protection against oxidative stress and the regulation of metabolic functions, which is strongly implicated in neurodegenerative diseases and carcinogenic processes. Furthermore, NQO1 is also involved in the modes of action of redox-active drugs (e.g., antimalarials). Determining the activity and localization of NQO1 in living organisms is of great importance for early disease diagnosis and therapy. As a promising and convenient biosensing technique, trimethyl lock quinone-based organic molecular probes have been well established for the specific detection and imaging of NQO1 in living cells and in vivo. In this review, the recent progress of NQO1 probes based on organic small molecules is summarized from the perspectives of molecular design strategies, sensing mechanisms and bioimaging applications. We also elucidate the potential limitations and prospects of current NQO1 probes to further promote the development of versatile imaging tools for NQO1-related biomedical investigation.https://www.mdpi.com/2227-9040/11/4/221NQO1oxidative stressquinonesorganic probesbioimaging |
| spellingShingle | Kun Chen Shuai Xu Zhiling Song Ke Li Trimethyl Lock Quinone-Based Organic Molecular Probes for NQO1 Sensing and Imaging Chemosensors NQO1 oxidative stress quinones organic probes bioimaging |
| title | Trimethyl Lock Quinone-Based Organic Molecular Probes for NQO1 Sensing and Imaging |
| title_full | Trimethyl Lock Quinone-Based Organic Molecular Probes for NQO1 Sensing and Imaging |
| title_fullStr | Trimethyl Lock Quinone-Based Organic Molecular Probes for NQO1 Sensing and Imaging |
| title_full_unstemmed | Trimethyl Lock Quinone-Based Organic Molecular Probes for NQO1 Sensing and Imaging |
| title_short | Trimethyl Lock Quinone-Based Organic Molecular Probes for NQO1 Sensing and Imaging |
| title_sort | trimethyl lock quinone based organic molecular probes for nqo1 sensing and imaging |
| topic | NQO1 oxidative stress quinones organic probes bioimaging |
| url | https://www.mdpi.com/2227-9040/11/4/221 |
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