Therapy Implications of Hepatitis C Virus Genetic Diversity
Hepatitis C virus (HCV) is an important human pathogen with a high chronicity rate. An estimated 71 million people worldwide are living with chronic hepatitis C (CHC) infection, which carries the risk of progression to hepatic fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). Similar to other...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-12-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/13/1/41 |
| _version_ | 1797543147188781056 |
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| author | Miguel Angel Martinez Sandra Franco |
| author_facet | Miguel Angel Martinez Sandra Franco |
| author_sort | Miguel Angel Martinez |
| collection | DOAJ |
| description | Hepatitis C virus (HCV) is an important human pathogen with a high chronicity rate. An estimated 71 million people worldwide are living with chronic hepatitis C (CHC) infection, which carries the risk of progression to hepatic fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). Similar to other RNA viruses, HCV has a high rate of genetic variability generated by its high mutation rate and the actions of evolutionary forces over time. There are two levels of HCV genetic variability: intra-host variability, characterized by the distribution of HCV mutant genomes present in an infected individual, and inter-host variability, represented by the globally circulating viruses that give rise to different HCV genotypes and subtypes. HCV genetic diversity has important implications for virus persistence, pathogenesis, immune responses, transmission, and the development of successful vaccines and antiviral strategies. Here we will discuss how HCV genetic heterogeneity impacts viral spread and therapeutic control. |
| first_indexed | 2024-03-10T13:41:33Z |
| format | Article |
| id | doaj.art-53b91de6248e49e785c361bd73687d65 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T13:41:33Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-53b91de6248e49e785c361bd73687d652023-11-21T03:00:03ZengMDPI AGViruses1999-49152020-12-011314110.3390/v13010041Therapy Implications of Hepatitis C Virus Genetic DiversityMiguel Angel Martinez0Sandra Franco1Miguel Angel Martínez, IrsiCaixa, Hospital Universitari Germans Trias i Pujol, 08916 Badalona, SpainMiguel Angel Martínez, IrsiCaixa, Hospital Universitari Germans Trias i Pujol, 08916 Badalona, SpainHepatitis C virus (HCV) is an important human pathogen with a high chronicity rate. An estimated 71 million people worldwide are living with chronic hepatitis C (CHC) infection, which carries the risk of progression to hepatic fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). Similar to other RNA viruses, HCV has a high rate of genetic variability generated by its high mutation rate and the actions of evolutionary forces over time. There are two levels of HCV genetic variability: intra-host variability, characterized by the distribution of HCV mutant genomes present in an infected individual, and inter-host variability, represented by the globally circulating viruses that give rise to different HCV genotypes and subtypes. HCV genetic diversity has important implications for virus persistence, pathogenesis, immune responses, transmission, and the development of successful vaccines and antiviral strategies. Here we will discuss how HCV genetic heterogeneity impacts viral spread and therapeutic control.https://www.mdpi.com/1999-4915/13/1/41HCVgenetic diversityquasispeciestherapy |
| spellingShingle | Miguel Angel Martinez Sandra Franco Therapy Implications of Hepatitis C Virus Genetic Diversity Viruses HCV genetic diversity quasispecies therapy |
| title | Therapy Implications of Hepatitis C Virus Genetic Diversity |
| title_full | Therapy Implications of Hepatitis C Virus Genetic Diversity |
| title_fullStr | Therapy Implications of Hepatitis C Virus Genetic Diversity |
| title_full_unstemmed | Therapy Implications of Hepatitis C Virus Genetic Diversity |
| title_short | Therapy Implications of Hepatitis C Virus Genetic Diversity |
| title_sort | therapy implications of hepatitis c virus genetic diversity |
| topic | HCV genetic diversity quasispecies therapy |
| url | https://www.mdpi.com/1999-4915/13/1/41 |
| work_keys_str_mv | AT miguelangelmartinez therapyimplicationsofhepatitiscvirusgeneticdiversity AT sandrafranco therapyimplicationsofhepatitiscvirusgeneticdiversity |