Follow up after IMRT in oral cavity cancer: update
<p><b>Abstract</b></p> <p><b>Purpose</b></p> <p>Except for early stages (T1/2 N0), the prognosis for patients with oral cavity cancer (OCC) is known to be worse than for those with pharyngeal carcinoma. While definitive intensity modulated radiat...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2012-06-01
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| Series: | Radiation Oncology |
| Subjects: | |
| Online Access: | http://www.ro-journal.com/content/7/1/84 |
| _version_ | 1818777218051997696 |
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| author | Studer Gabriela Brown Michelle Bredell Marius Graetz Klaus W Huber Gerhard Linsenmeier Claudia Najafi Yousef Riesterer Oliver Rordorf Tamara Schmid Stephan Glanzmann Christoph |
| author_facet | Studer Gabriela Brown Michelle Bredell Marius Graetz Klaus W Huber Gerhard Linsenmeier Claudia Najafi Yousef Riesterer Oliver Rordorf Tamara Schmid Stephan Glanzmann Christoph |
| author_sort | Studer Gabriela |
| collection | DOAJ |
| description | <p><b>Abstract</b></p> <p><b>Purpose</b></p> <p>Except for early stages (T1/2 N0), the prognosis for patients with oral cavity cancer (OCC) is known to be worse than for those with pharyngeal carcinoma. While definitive intensity modulated radiation therapy (IMRT)-chemotherapy affords loco-regional control rates (LRC) of approximately 80% in advanced pharyngeal cancer, corresponding rates are reported to be much lower for OCC. The aim of this work was to evaluate loco-regional disease control and overall survival (OAS) in a relatively large OCC patient cohort treated in the IMRT era.</p> <p><b>Methods and materials</b></p> <p>Between October 2002 and June 2011, 160 OCC patients were treated with curative intention IMRT at our department. 122 patients (76%) were referred with primary disease and 38 patients (24%) with a recurrent OCC at least 3 months after surgery alone. Definitive IMRT was performed in 44/160 patients (28%), whilst 116 patients underwent previous surgery. Simultaneous systemic therapy was administered in 72%.</p> <p><b>Results</b></p> <p>Patients with postoperative IMRT (+/−systemic therapy) with R0-1 status (n = 99) reached significantly higher LRC/OAS rates than patients following IMRT for macroscopic disease (n = 61), with 84%/80% versus 38%/33% at 3 years, respectively (p < 0.0001). This was found in patients treated for initial, as well as recurrent, disease. Less than 2% persisting grade 3/4 late effects were observed.</p> <p><b>Conclusions</b></p> <p>IMRT for R0-1 situations translated into a highly significant superior LRC and OAS compared to the IMRT cohort treated for macroscopic disease. Treatment was well tolerated.</p> |
| first_indexed | 2024-12-18T11:25:20Z |
| format | Article |
| id | doaj.art-53ba0a734fd84fb4a9c72ad6eb398dcf |
| institution | Directory Open Access Journal |
| issn | 1748-717X |
| language | English |
| last_indexed | 2024-12-18T11:25:20Z |
| publishDate | 2012-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Radiation Oncology |
| spelling | doaj.art-53ba0a734fd84fb4a9c72ad6eb398dcf2022-12-21T21:09:43ZengBMCRadiation Oncology1748-717X2012-06-01718410.1186/1748-717X-7-84Follow up after IMRT in oral cavity cancer: updateStuder GabrielaBrown MichelleBredell MariusGraetz Klaus WHuber GerhardLinsenmeier ClaudiaNajafi YousefRiesterer OliverRordorf TamaraSchmid StephanGlanzmann Christoph<p><b>Abstract</b></p> <p><b>Purpose</b></p> <p>Except for early stages (T1/2 N0), the prognosis for patients with oral cavity cancer (OCC) is known to be worse than for those with pharyngeal carcinoma. While definitive intensity modulated radiation therapy (IMRT)-chemotherapy affords loco-regional control rates (LRC) of approximately 80% in advanced pharyngeal cancer, corresponding rates are reported to be much lower for OCC. The aim of this work was to evaluate loco-regional disease control and overall survival (OAS) in a relatively large OCC patient cohort treated in the IMRT era.</p> <p><b>Methods and materials</b></p> <p>Between October 2002 and June 2011, 160 OCC patients were treated with curative intention IMRT at our department. 122 patients (76%) were referred with primary disease and 38 patients (24%) with a recurrent OCC at least 3 months after surgery alone. Definitive IMRT was performed in 44/160 patients (28%), whilst 116 patients underwent previous surgery. Simultaneous systemic therapy was administered in 72%.</p> <p><b>Results</b></p> <p>Patients with postoperative IMRT (+/−systemic therapy) with R0-1 status (n = 99) reached significantly higher LRC/OAS rates than patients following IMRT for macroscopic disease (n = 61), with 84%/80% versus 38%/33% at 3 years, respectively (p < 0.0001). This was found in patients treated for initial, as well as recurrent, disease. Less than 2% persisting grade 3/4 late effects were observed.</p> <p><b>Conclusions</b></p> <p>IMRT for R0-1 situations translated into a highly significant superior LRC and OAS compared to the IMRT cohort treated for macroscopic disease. Treatment was well tolerated.</p>http://www.ro-journal.com/content/7/1/84IMRT in oral cavity cancerDefinitive IMRT for oral cavity cancerPrognostic parameter in oral cavity cancerSalvage treatment for recurrent oral cavity cancerRecurrent oral cavity cancer |
| spellingShingle | Studer Gabriela Brown Michelle Bredell Marius Graetz Klaus W Huber Gerhard Linsenmeier Claudia Najafi Yousef Riesterer Oliver Rordorf Tamara Schmid Stephan Glanzmann Christoph Follow up after IMRT in oral cavity cancer: update Radiation Oncology IMRT in oral cavity cancer Definitive IMRT for oral cavity cancer Prognostic parameter in oral cavity cancer Salvage treatment for recurrent oral cavity cancer Recurrent oral cavity cancer |
| title | Follow up after IMRT in oral cavity cancer: update |
| title_full | Follow up after IMRT in oral cavity cancer: update |
| title_fullStr | Follow up after IMRT in oral cavity cancer: update |
| title_full_unstemmed | Follow up after IMRT in oral cavity cancer: update |
| title_short | Follow up after IMRT in oral cavity cancer: update |
| title_sort | follow up after imrt in oral cavity cancer update |
| topic | IMRT in oral cavity cancer Definitive IMRT for oral cavity cancer Prognostic parameter in oral cavity cancer Salvage treatment for recurrent oral cavity cancer Recurrent oral cavity cancer |
| url | http://www.ro-journal.com/content/7/1/84 |
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