Insights Into the Role of CSF1R in the Central Nervous System and Neurological Disorders
The colony-stimulating factor 1 receptor (CSF1R) is a key tyrosine kinase transmembrane receptor modulating microglial homeostasis, neurogenesis, and neuronal survival in the central nervous system (CNS). CSF1R, which can be proteolytically cleaved into a soluble ectodomain and an intracellular prot...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-11-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2021.789834/full |
| _version_ | 1818568820962361344 |
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| author | Banglian Hu Shengshun Duan Ziwei Wang Xin Li Yuhang Zhou Xian Zhang Yun-Wu Zhang Huaxi Xu Honghua Zheng Honghua Zheng |
| author_facet | Banglian Hu Shengshun Duan Ziwei Wang Xin Li Yuhang Zhou Xian Zhang Yun-Wu Zhang Huaxi Xu Honghua Zheng Honghua Zheng |
| author_sort | Banglian Hu |
| collection | DOAJ |
| description | The colony-stimulating factor 1 receptor (CSF1R) is a key tyrosine kinase transmembrane receptor modulating microglial homeostasis, neurogenesis, and neuronal survival in the central nervous system (CNS). CSF1R, which can be proteolytically cleaved into a soluble ectodomain and an intracellular protein fragment, supports the survival of myeloid cells upon activation by two ligands, colony stimulating factor 1 and interleukin 34. CSF1R loss-of-function mutations are the major cause of adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) and its dysfunction has also been implicated in other neurodegenerative disorders including Alzheimer’s disease (AD). Here, we review the physiological functions of CSF1R in the CNS and its pathological effects in neurological disorders including ALSP, AD, frontotemporal dementia and multiple sclerosis. Understanding the pathophysiology of CSF1R is critical for developing targeted therapies for related neurological diseases. |
| first_indexed | 2024-12-14T06:40:07Z |
| format | Article |
| id | doaj.art-53bb5fb9cc324956904e32d33c9434ab |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-14T06:40:07Z |
| publishDate | 2021-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-53bb5fb9cc324956904e32d33c9434ab2022-12-21T23:13:15ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652021-11-011310.3389/fnagi.2021.789834789834Insights Into the Role of CSF1R in the Central Nervous System and Neurological DisordersBanglian Hu0Shengshun Duan1Ziwei Wang2Xin Li3Yuhang Zhou4Xian Zhang5Yun-Wu Zhang6Huaxi Xu7Honghua Zheng8Honghua Zheng9Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, School of Medicine, Institute of Neuroscience, Xiamen University, Xiamen, ChinaFujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, School of Medicine, Institute of Neuroscience, Xiamen University, Xiamen, ChinaFujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, School of Medicine, Institute of Neuroscience, Xiamen University, Xiamen, ChinaFujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, School of Medicine, Institute of Neuroscience, Xiamen University, Xiamen, ChinaFujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, School of Medicine, Institute of Neuroscience, Xiamen University, Xiamen, ChinaFujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, School of Medicine, Institute of Neuroscience, Xiamen University, Xiamen, ChinaFujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, School of Medicine, Institute of Neuroscience, Xiamen University, Xiamen, ChinaFujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, School of Medicine, Institute of Neuroscience, Xiamen University, Xiamen, ChinaFujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, School of Medicine, Institute of Neuroscience, Xiamen University, Xiamen, ChinaBasic Medical Sciences, School of Medicine, Xiamen University, Xiamen, ChinaThe colony-stimulating factor 1 receptor (CSF1R) is a key tyrosine kinase transmembrane receptor modulating microglial homeostasis, neurogenesis, and neuronal survival in the central nervous system (CNS). CSF1R, which can be proteolytically cleaved into a soluble ectodomain and an intracellular protein fragment, supports the survival of myeloid cells upon activation by two ligands, colony stimulating factor 1 and interleukin 34. CSF1R loss-of-function mutations are the major cause of adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) and its dysfunction has also been implicated in other neurodegenerative disorders including Alzheimer’s disease (AD). Here, we review the physiological functions of CSF1R in the CNS and its pathological effects in neurological disorders including ALSP, AD, frontotemporal dementia and multiple sclerosis. Understanding the pathophysiology of CSF1R is critical for developing targeted therapies for related neurological diseases.https://www.frontiersin.org/articles/10.3389/fnagi.2021.789834/fullCSF1Rmicrogliamicroglial maintenanceneurogenesisCSF1R cleavageCSF1R mutations |
| spellingShingle | Banglian Hu Shengshun Duan Ziwei Wang Xin Li Yuhang Zhou Xian Zhang Yun-Wu Zhang Huaxi Xu Honghua Zheng Honghua Zheng Insights Into the Role of CSF1R in the Central Nervous System and Neurological Disorders Frontiers in Aging Neuroscience CSF1R microglia microglial maintenance neurogenesis CSF1R cleavage CSF1R mutations |
| title | Insights Into the Role of CSF1R in the Central Nervous System and Neurological Disorders |
| title_full | Insights Into the Role of CSF1R in the Central Nervous System and Neurological Disorders |
| title_fullStr | Insights Into the Role of CSF1R in the Central Nervous System and Neurological Disorders |
| title_full_unstemmed | Insights Into the Role of CSF1R in the Central Nervous System and Neurological Disorders |
| title_short | Insights Into the Role of CSF1R in the Central Nervous System and Neurological Disorders |
| title_sort | insights into the role of csf1r in the central nervous system and neurological disorders |
| topic | CSF1R microglia microglial maintenance neurogenesis CSF1R cleavage CSF1R mutations |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2021.789834/full |
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