GWAS and functional studies suggest a role for altered DNA repair in the evolution of drug resistance in Mycobacterium tuberculosis

GWAS and functional studies suggest a role for altered DNA repair in the evolution of drug resistance in Mycobacterium tuberculosis

The emergence of drug resistance in Mycobacterium tuberculosis (Mtb) is alarming and demands in-depth knowledge for timely diagnosis. We performed genome-wide association analysis using 2237 clinical strains of Mtb to identify novel genetic factors that evoke drug resistance. In addition to the know...

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Hlavní autoři: Saba Naz, Kumar Paritosh, Priyadarshini Sanyal, Sidra Khan, Yogendra Singh, Umesh Varshney, Vinay Kumar Nandicoori
Médium: Článek
Jazyk:English
Vydáno: eLife Sciences Publications Ltd 2023-01-01
Edice:eLife
Témata:
mycobacterium tuberculosis
drug resistance
DNA repair
On-line přístup:https://elifesciences.org/articles/75860

Internet

https://elifesciences.org/articles/75860

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