Degenerated nucleus pulposus cells derived exosome carrying miR-27a-3p aggravates intervertebral disc degeneration by inducing M1 polarization of macrophages

Degenerated nucleus pulposus cells derived exosome carrying miR-27a-3p aggravates intervertebral disc degeneration by inducing M1 polarization of macrophages

Abstract Background Intervertebral disc degeneration (IVDD) is a major contributor to spinal disorders. Previous studies have indicated that the infiltration of immunocytes, specifically macrophages, plays a crucial role in the advancement of IVDD. Exosomes (exo) are believed to play a significant r...

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Bibliographic Details
Main Authors: Xin Zhao, Zhen Sun, Benchi Xu, Wei Duan, Le Chang, Kangwei Lai, Zhengxu Ye
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Journal of Nanobiotechnology
Subjects:
Intervertebral disc degeneration
Nucleus pulposus
Exosome
Macrophages
Inflammatory regulation
Online Access:https://doi.org/10.1186/s12951-023-02075-y

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